Electrospun Blank Nanocoating for Improved Sustained Release Profiles from Medicated Gliadin Nanofibers

Liu, Xinkuan; Shao, Wenyi; Luo, Mingyi; Bian, Jiayin; Yu, Deng‐Guang

doi:10.3390/nano8040184

Cited by 42 publications

(12 citation statements)

References 44 publications

(54 reference statements)

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“…Nanostructures of cellulose derivatives can be prepared both, by top-down and bottom-up techniques. Among top-down techniques, electrospinning allows attaining a large variety of complex structures which have demonstrated to be useful for the controlled release of drugs (Liu et al 2018;Yang et al 2019;Wang et al 2017). As for bottom-up techniques, the low-energy emulsification approach is an environmentally friendly method, which has been reported for the preparation of ethylcellulose nanoparticles (Spernarth et al 2007;Generalova et al 2009;Calderó et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Ethylcellulose nanoparticles as a new “in vitro” transfection tool for antisense oligonucleotide delivery

Leitner

Grijalvo

Solans

et al. 2020

Carbohydrate Polymers

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Oil-in-water nano-emulsions have been obtained in the HEPES 20 mM buffer solution / [Alkylamidoammonium:Kolliphor EL=1:1] / [6 weight % ethylcellulose in ethyl acetate] system over a wide oil-to-surfactant (O/S) range and above 35 weight% aqueous component at 25ºC. The nano-emulsion with an O/S ratio of 70/30 and 95 weight % aqueous component was used for nanoparticles preparation. These nanoparticles (mean diameter around 90 nm and zeta potential of +22 mV) were non-toxic to HeLa cells up to a concentration of 3 mM of cationic species. Successful complexation with an antisense phosphorothioate oligonucleotide targeting Renilla luciferase mRNA was achieved at cationic/anionic charge ratios above 16, as confirmed by zeta potential measurements and an electrophoretic mobility shift assay, provided that no Fetal Bovine Serum is present in the cell culture medium. Importantly, Renilla luciferase gene inhibition shows an optimum efficiency (40%) for the cationic/anionic ratio 28, which makes these complexes promising for "in vitro" cell transfection.

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Section: Introductionmentioning

confidence: 99%

Ethylcellulose nanoparticles as a new “in vitro” transfection tool for antisense oligonucleotide delivery

Leitner

Grijalvo

Solans

et al. 2020

Carbohydrate Polymers

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“…As a therapeutic carrier, nanofiber can improve the drug-loading capacity and effectively control drug release. Moreover, the nanofibrous matrix may exert a discernible impact on the safety of guest materials while not compromising their function 27,31,32…”

Section: Introductionmentioning

confidence: 99%

<p>Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment</p>

Zhao¹,

Zhu²,

Ye³

et al. 2019

IJN

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Background: Photothermal and chemotherapy treatment has been frequently studied for cancer therapy; however, chemotherapy is equally toxic to both normal and cancer cells. The clinical application value of most kinds of photothermal transforming agents remains limited, due to their poor degradation and minimal accumulation in tumors. Materials and methods: We reported the synthesis of photothermal transforming agents (MoS 2 ) and chemotherapeutic (doxorubicin, DOX) co-loaded electrospun nanofibers using blend electrospinning for the treatment of postoperative tumor recurrence. Results: Under the irradiation of an 808 nm laser, the as-prepared chitosan/polyvinyl alcohol/MoS 2 /DOX nanofibers showed an admirable photothermal conversion capability with a photothermal conversion efficiency of 23.2%. These composite nanofibers are in vitro and in vivo biocompatible. In addition, they could control the sustained release of DOX and the generated heat can sensitize the chemotherapeutic efficacy of DOX via enhancing its release rate. Their chemo-/photothermal combined therapy efficiency was systematically studied in vitro and in vivo. Instead of circulating with the body fluid, MoS 2 was trapped by the nanofibrous matrix in the tumor and so its tumor-killing ability was not compromised, thus rendering this composite nanofiber a promising alternative for future clinical translation within biomedical application fields. Conclusion: Chitosan/polyvinyl alcohol/MoS 2 /DOX nanofibers showed an excellent photothermal conversion capability with a photothermal conversion efficiency of 23.2% and can completely inhibit the postoperative tumor reoccurrence.

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“…The simplest process involves a single fluid electrospinning of blending solutions of two or more components using a single needle, which produces monolithic fibers. − Because of the poor solubility of CPs such as polyaniline (PAni), polypyrrole (PPy), and poly(3,4-ethylenedioxythiophene) (PEDOT), most of the CP-based electrospun fibers were made by blending with other electrospinnable polymers in the form of monolithic fibers. − In these monolithic fibers, the CPs may or may not be homogeneously distributed, but they often compromised the conductive properties, limiting their functional performance. Coaxial electrospinning, which uses two needles and solutions, one nested inside the other, has the ability to mimic the spinneret’s structure, in a single step and straightforward manner to create core–sheath nanofibers with two distinct phases and improve the functionality of the nanofibers. − For a successful coaxial electrospinning process, it was believed that the electrospinnability of the sheath polymer solution was necessary in addition to the core polymer solution. Recently, a modified coaxial electrospinning was demonstrated using an unspinnable sheath solution to create core–sheath nanofibers with uniformly distributed ultrathin sheath layer on the core. − ,− This modified coaxial electrospinning process not only improves the functional performances of nanofibers by localizing the functional components in desired morphology but also greatly reduces the spinneret nozzle clogging problem as observed in single fluid electrospinning process.…”

Section: Introductionmentioning

confidence: 99%

“…Coaxial electrospinning, which uses two needles and solutions, one nested inside the other, has the ability to mimic the spinneret’s structure, in a single step and straightforward manner to create core–sheath nanofibers with two distinct phases and improve the functionality of the nanofibers. − For a successful coaxial electrospinning process, it was believed that the electrospinnability of the sheath polymer solution was necessary in addition to the core polymer solution. Recently, a modified coaxial electrospinning was demonstrated using an unspinnable sheath solution to create core–sheath nanofibers with uniformly distributed ultrathin sheath layer on the core. − ,− This modified coaxial electrospinning process not only improves the functional performances of nanofibers by localizing the functional components in desired morphology but also greatly reduces the spinneret nozzle clogging problem as observed in single fluid electrospinning process. The improved functional performances of various core–sheath nanofibers using a modified electrospinning process were demonstrated for improved drug delivery and release, ,,, and theranostic systems for magnetic resonance imaging. , …”

Section: Introductionmentioning

confidence: 99%

“…Recently, a modified coaxial electrospinning was demonstrated using an unspinnable sheath solution to create core–sheath nanofibers with uniformly distributed ultrathin sheath layer on the core. − ,− This modified coaxial electrospinning process not only improves the functional performances of nanofibers by localizing the functional components in desired morphology but also greatly reduces the spinneret nozzle clogging problem as observed in single fluid electrospinning process. The improved functional performances of various core–sheath nanofibers using a modified electrospinning process were demonstrated for improved drug delivery and release, ,,, and theranostic systems for magnetic resonance imaging. , …”

Section: Introductionmentioning

confidence: 99%

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Amine-Functionalized Electrically Conductive Core–Sheath MEH-PPV:PCL Electrospun Nanofibers for Enhanced Cell–Biomaterial Interactions

Borah

Ingavle

Sandeman

et al. 2018

ACS Biomater. Sci. Eng.

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In the present study, a conducting polymer, poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV) along with a biodegradable polymer poly(ε-caprolactone) (PCL) was used to prepare an electrically conductive, biocompatible, bioactive and biodegradable nanofibrous scaffold for possible use in neural tissue engineering applications. Core-sheath electrospun nanofibres of PCL as the core and MEH-PPV as the sheath, were surface-functionalized with (3-aminopropyl) triethoxysilane (APTES) and 1,6-hexanediamine to obtain amine functionalized surface to facilitate cell-biomaterial interactions with the aim of replacing the costly biomolecules such as collagen, fibronectin, laminin and arginyl-glycylaspartic acid (RGD) peptide for surface modification. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) confirmed the formation of core-sheath morphology of the electrospun nanofibres, while Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) revealed successful incorporation of amine functionality after surface functionalization. Adhesion, spreading and proliferation of 3T3 fibroblast were enhanced on the surface functionalized electrospun meshes, while the neuronal model rat pheochromocytoma 12 (PC12) cells also adhered and differentiated into sympathetic neurons on these meshes. Under a constant electric field of 200 mV for 2h/day for 3 consecutive days, the PC12 cells displayed remarkable improvement in the neurite formation and outgrowth on the surface functionalized meshes that was comparable to those on the collagen coated meshes under no electrical signal. Electrical stimulation studies further demonstrated that electrically stimulated PC12 cells cultured on collagen I coated meshes yielded more and longer neurites than those of the unstimulated cells on the same scaffolds. The enhanced neurite growth and differentiation suggest the potential use of these scaffolds for neural tissue engineering applications.

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Electrospun Blank Nanocoating for Improved Sustained Release Profiles from Medicated Gliadin Nanofibers

Cited by 42 publications

References 44 publications

Ethylcellulose nanoparticles as a new “in vitro” transfection tool for antisense oligonucleotide delivery

Ethylcellulose nanoparticles as a new “in vitro” transfection tool for antisense oligonucleotide delivery

<p>Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment</p>

Amine-Functionalized Electrically Conductive Core–Sheath MEH-PPV:PCL Electrospun Nanofibers for Enhanced Cell–Biomaterial Interactions

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