Electrospun Biomimetic Periosteum Capable of Controlled Release of Multiple Agents for Programmed Promoting Bone Regeneration
Xingkai Zhao,
Yu Zhuang,
Yongjian Cao
et al.
Abstract:The effective repair of large bone defects remains a major challenge due to its limited self‐healing capacity. Inspired by the structure and function of the natural periosteum, an electrospun biomimetic periosteum is constructed to programmatically promote bone regeneration using natural bone healing mechanisms. The biomimetic periosteum is composed of a bilayer with an asymmetric structure in which an aligned electrospun poly(ε‐caprolactone)/gelatin/deferoxamine (PCL/GEL/DFO) layer mimics the outer fibrous la… Show more
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