Electrospun aligned nanofibers: A review

Han, Weihua; Wang, Meiqin; Yuan, Jinxiu; Hao, Chuncheng; Li, Chengjie; Long, Yun‐Ze; Ramakrishna, Seeram

doi:10.1016/j.arabjc.2022.104193

Cited by 23 publications

(17 citation statements)

References 67 publications

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“…Among them, modifying the electrospinning fiber-collecting device has attracted much attention. For instance, a high-speed metal roller and two oppositely placed metal electrodes with a constant gap, etc., have been developed as advanced electrospun fiber collectors to control the alignment of electrospinning nanofibers to fabricate electrospun scaffolds with uniaxially oriented nanofibrous patterns [ 30 , 31 ]. In this study, one new-type electrode with a pin-ring-like structure was designed and implemented to collect electrospun nanofibers in the form of a radially oriented structure.…”

Section: Resultsmentioning

confidence: 99%

Designing an Innovative Electrospinning Strategy to Generate PHBV Nanofiber Scaffolds with a Radially Oriented Fibrous Pattern

Wang

Chen

et al. 2023

Nanomaterials

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Electrospinning has contributed substantially to the construction of nanofibrous scaffolds for potential tissue engineering and regenerative medicine applications. However, conventional electrospinning only has the ability to generate and collect nanofiber scaffolds with a randomly oriented fibrous pattern, which lack the necessary cell alignment guidance function. In this study, a novel electrospinning fiber-collecting device was designed and developed by setting a series of small pin-ring-structured collectors on a large plain plate. Specifically, we demonstrated that the pin-ring-structured collectors, which were constructed by inserting a metal pin into the center of a metal ring, could collect the as-electrospun nanofibers with radially oriented structures in an innovative manner. We first investigated the suitable polymeric concentration for electrospinning poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and the optimum electrospinning concentration of PHBV was found to be 12% (w/v) PHBV dissolved in hexafluoroisopropyl alcohol (HFIP). Then, 12% (w/v) PHBV solution was electrospun into radially oriented nanofiber scaffolds using our novel electrospinning strategy, and their various performances were further compared with conventionally randomly oriented nanofiber scaffolds that were also produced from 12% (w/v) PHBV solution. The results showed that the radially oriented PHBV nanofiber scaffolds exhibited obviously enhanced mechanical properties and decreased hydrophobicity compared with the randomly oriented PHBV nanofiber scaffold controls. Importantly, the biological properties of radially oriented PHBV nanofiber scaffolds were also demonstrated to be enhanced, compared with randomly oriented PHBV nanofiber scaffolds, by effectively inducing cell alignment and significantly promoting cell proliferation. In sum, the present study indicates that our as-prepared nanofiber scaffolds with a radially oriented pattern are of great interest for advanced applications, such as wound dressings and tissue-engineered scaffolds.

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Section: Resultsmentioning

confidence: 99%

Designing an Innovative Electrospinning Strategy to Generate PHBV Nanofiber Scaffolds with a Radially Oriented Fibrous Pattern

Wang

Chen

et al. 2023

Nanomaterials

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“…The preparation methods for aligned nanofibers have been summarized in our previous work. 15 In brief, the most widely used method is the rotating collector, 16,17 in terms of both the alignment degree and the preparation efficiency of fibers, while the highest-precision control method is near-field e-spinning, regardless of the diameter of fibers. 18 Helical nanofibers are mainly used to manufacture flexible electronic devices 19 because they cannot easily fracture when stretched to a large extent.…”

Section: Electrospinningmentioning

confidence: 99%

“…In our previous work, we have compared the heating methods for reference, as shown in Table 1. 15 Fig. 2 Classical e-spinning device and e-spun products.…”

Section: Electrospinningmentioning

confidence: 99%

Electrospun polymer nanocomposites for thermal management: a review

et al. 2023

Self Cite

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“…They are being researched and created since they hold great potential for a wide range of uses while also achieving some of the benefits of nanostructured materials. [1][2][3] Moreover, the field of nanofibers has piqued the attention in the fields of biotechnology and biomedicine, such as affinity membranes, nanosensors, wound dressings, tissue engineering, drug delivery systems (DDS), and so on. [4][5][6] Electrospinning, as an effective technique in the production of nanofibers, is widely used since the produced fibers have a uniform appearance.…”

Section: Introductionmentioning

confidence: 99%

“…Nanofibers excite a lot of interest nowadays owing to their excellent characteristics. They are being researched and created since they hold great potential for a wide range of uses while also achieving some of the benefits of nanostructured materials 1–3 . Moreover, the field of nanofibers has piqued the attention in the fields of biotechnology and biomedicine, such as affinity membranes, nanosensors, wound dressings, tissue engineering, drug delivery systems (DDS), and so on 4–6 .…”

Section: Introductionmentioning

confidence: 99%

A novel polyhydroxyalkanoate/polyvinyl alcohol composite porous membrane via electrospinning and spin coating as potential application for chemotherapy and tissue engineering

Chen

Yan

et al. 2023

Polymers for Advanced Techs

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Polyhydroxyalkanoate/polyvinyl alcohol (PHA/PVA) composite porous membranes were successfully prepared by coupling of electrospinning and spin‐coating. The resulting composite membranes were characterized by scanning electron microscope (SEM), FT‐IR spectrometer, x‐ray diffraction (XRD), contact angle tester and Brunner–Emmet–Teller (BET). It indicated that the PHA/PVA membrane belonged to a mesoporous material, which can be used as a drug delivery carrier for doxorubicin hydrochloride (DOX). In vitro drug release experiments showed that DOX loaded PHA/PVA composite membranes presented higher DOX release level in acidic environment than that in neutral environment since the degradation rate of the membranes under pH = 4 was significantly higher. And that, the DOX loaded membranes exhibited excellent performance for inhibiting the growth of Caco‐2 cells, which revealed the membranes' biomedical potential for chemotherapy of colon cancer. Meanwhile, in view of the good adhesion of the cells to the membranes, this novel mesoporous material was also perspective in tissue engineering.

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Electrospun aligned nanofibers: A review

Cited by 23 publications

References 67 publications

Designing an Innovative Electrospinning Strategy to Generate PHBV Nanofiber Scaffolds with a Radially Oriented Fibrous Pattern

Designing an Innovative Electrospinning Strategy to Generate PHBV Nanofiber Scaffolds with a Radially Oriented Fibrous Pattern

Electrospun polymer nanocomposites for thermal management: a review

A novel polyhydroxyalkanoate/polyvinyl alcohol composite porous membrane via electrospinning and spin coating as potential application for chemotherapy and tissue engineering

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