Electrospun acid–base pair solid dispersions of quercetin

Yan, Jie; Wu, Yangjie; Yu, Deng‐Guang; Williams, Gareth R.; Huang, Suzhen; Wen, Tao; Sun, Jun‐Yi

doi:10.1039/c4ra10221e

Cited by 37 publications

(25 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As expected, the two dyes existed in their polymer matrices in an amorphous state (ESI †), suggesting that the side-by-side electrospinning processes described here can be exploited for the preparation of Janus structural composites, which are popular for designing new functional materials. 23 Particularly, the amorphous status is highly desirable for improving the dissolution of poorly water soluble drugs (one of the most difficult challenges in pharmaceutics), [24][25][26] and thus the present processes should provide a new platform for developing drug delivery systems for combined therapy from poorly water soluble active pharmaceutical ingredients. Moreover, these tunable Janus fiber structures should have good potential applications for fibrous guided tissue regeneration membranes because not only multiple functional ingredients such as anti-inflammatory agents, adhesive components for cell attachment and even nutritional ingredients can be loaded in them, but also one side can be managed to degrade to make way for proliferating cells.…”

mentioning

confidence: 99%

Structure-tunable Janus fibers fabricated using spinnerets with varying port angles

Chen

et al. 2015

Chem. Commun.

Self Cite

View full text Add to dashboard Cite

aThe preparation of Janus fibers using a new side-by-side electrospinning process is reported. By manipulating the angle between the two ports of the spinneret emitting the working fluids, Janus nanofibers with tunable structures in terms of width, interfacial area and also volume of each side can be easily fabricated.Among the different ''top-down'' processes for nanofabrication, electrohydrodynamic atomization processes (EHDA, including electrospinning, electrospraying and e-jetting printing) have the unique capability of simultaneous modulation of sizes, shapes and compartmentalization of their nanoproducts.1,2 This ability has been broadly exploited for the generation of core-shell nanostructures, both in the form of electrospun fibers, nanotubes 3-5 and electrosprayed particles or bubbles. [6][7][8] Most recently, even complex structures such as tri-axial nanofibers have also been investigated using multi-fluid electrospinning processes. [9][10][11][12] In sharp contrast, there are still very limited studies about the generation of sideby-side structures using these EHDA processes. [13][14][15][16][17][18][19][20][21] To create structures with double compartments, two types of relationships between components are feasible, one is the exterior and interior (i.e. a core-shell structure), and the other is side-by-side. The latter, being a heterojunction structure, can have an advantage for designing novel functional nanomaterials over the core-shell structures because it provides an opportunity for both components to interact with their surroundings. 22,23Side-by-side electrospinning involves a complex interplay between fluid dynamics, electrodynamics and rheology, and presents a challenge in controlling the movement in unison of two fluids in a side-by-side manner under an electrical field from spinneret to collector. To our knowledge, Gupta and Wilkes were the first to report the preparation of side-by-side polymer nanofibers, made of poly(vinyl chloride)/segmented polyurethane and poly(vinyl chloride)-poly(vinylidiene fluoride) using a spinneret consisting of two parallel Teflon capillaries.13 Lin et al. reported the preparation of self-crimping side-by-side nanofibers that spontaneously formed curled helical fibers, composed of polyacrylonitrile and polyurethane, using a homemade silicone microfluidic spinneret, which consisted of three capillary channels with two of them combined in another channel in parallel to form the side-by-side outlet. 14 Later, several publications describe the preparation of side-by-side nanofibers using spinnerets made from two syringes whose needle tips were confined in a side-byside geometry. [15][16][17][18] In all these studies it was possible to control the outlet of the double fluids in a parallel manner for successful preparation of Janus nanofibers. Using a different approach, we report here side-by-side electrospinning in which a series of spinnerets with varying port angles were exploited to create structure-tunable Janus fibers. Our initial purpose was to prepare high...

show abstract

mentioning

confidence: 99%

Structure-tunable Janus fibers fabricated using spinnerets with varying port angles

Chen

et al. 2015

Chem. Commun.

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, more significant modifications to electrospinning always concern the spinneret, by which different processes have been developed, such as coaxial electrospinning, side-by-side and needleless electrospinning [10][11][12]. The homemade concentric spinneret exploited here is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Shellac nanofibers prepared using a modified coaxial electrospinning with a Triton X-100 solution as the sheath fluid

Wu¹,

Yang²,

Lu³

et al. 2015

Proceedings of the 4th International Conference on Mechatronics, Materials, Chemistry and Computer Engineering 2015

Self Cite

View full text Add to dashboard Cite

Abstract. The present study reports that a modified coaxial electrospinning process, which was successfully carried out to control the diameters of shellac fibers. With a Triton-X100 in ethanol as sheath working solution and shellac ethanol solution as a core electrospinnable fluid, the coaxial electrospinning processes can be conducted continuously and smoothly. Optical observations of the electrospinning process demonstrated that both a single-fluid and a coaxial process can be realized using the same apparatus. Field-emission scanning electron microscopy results demonstrated that the flow rate of sheath Triton X-100 solutions had a significant influence on the size of shellac fibers. As the sheath-to-core fluid flow rate ratio increased from 0 to 0.4, the shellac fibers' diameter decreased from 1.21 ± 0.41 µm to 0.19 ± 0.07 µm. The fibers' diameter (D, µm) has a clear linear relationship with the flow rate of sheath Triton X-100 solution (F): D = 1.08 -2.25 F (R 2 =0.9851).

show abstract

“…This technology is regarded as one of the most significant breakthroughs in the fields of electro hydrodynamic atomization [14]. It has been applied in controlling secondary structures of nanofibers, encapsulating drugs or biological agents into the polymeric nanofibers, fabricating polymeric microtubes, preparing nanofibers from materials that lack filament-forming properties and enclosing functional liquids within the fiber matrix [15,16]. During the coaxial electrospinning process the sheath solution acts as a guide and surrounds the core material, and the viscosity of the sheath solution is often required to overcome interfacial surface tension between the two working fluids so enabling the formation of a compound Taylor cone and a constant jet [17].…”

Section: From a Single-fluid Electrospinning To Traditional Coaxial Ementioning

confidence: 99%

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

Xiu¹,

Liu²,

Tan³

et al. 2017

dtssehs

Self Cite

View full text Add to dashboard Cite

Abstract. In higher education, the cultivation of innovation ability is very important for the college students. However, how to train innovative thinking is often a big concern for their teachers. In this paper, a simple way is shown, which is about how to guide the students to learn and to think about the evolution of a series of material processing technologies. With the integration of concepts from traditional wet spinning process with those from the single-fluid electrospinning, the modified coaxial electrospinning was hatched out from the traditional coaxial one. This evolution process comprises an excellent example to explain to the college students majoring in Materials Science and Engineering about engineering innovation. The thinking and explaining paradigm manifested in this example not only will be useful for the students to grasp new advanced technologies, promote them to do practical innovations, but also should be very useful for a wide variety of engineering disciplines to effectively take innovative engineering educations.

show abstract

Electrospun acid–base pair solid dispersions of quercetin

Cited by 37 publications

References 35 publications

Structure-tunable Janus fibers fabricated using spinnerets with varying port angles

Structure-tunable Janus fibers fabricated using spinnerets with varying port angles

Shellac nanofibers prepared using a modified coaxial electrospinning with a Triton X-100 solution as the sheath fluid

Hints from the Evolution of Material Processing Technologies for Engineering Education in Higher School

Contact Info

Product

Resources

About