Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles

Peltonen, Leena; Valo, Hanna; Kolakovic, Ruzica; Laaksonen, Timo; Hirvonen, Jouni

doi:10.1517/17425241003716802

Cited by 121 publications

(58 citation statements)

References 114 publications

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“…In biotechnology context, several criteria have to be taken into account for the selection of techniques to produce particles with controlled characteristics such as uniform size distribution, morphology, high purity, and composition. Additionally, the method should be simple, inexpensive, and have high throughput (Peltonen L. et al, 2010). In this section, general overviews of the methods to synthesise biological nanoparticles which include two steps procedures based on emulsification, a one-step procedure involving nanoprecipitation, desolvation, and gelation, and through drying methods are presented, with primary emphasis on the preparation by drying process.…”

Section: Methods To Synthesise Biological Nanoparticlesmentioning

confidence: 99%

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Saallah

Lenggoro

2018

KONA

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In the past few decades, enormous advances have been achieved in the field of particle technology and the trend has been shifted from macro to micro and recently to the nanoscale. Integration of nanotechnology and biotechnology has paved the way to the development of biological nanoparticles, derived from biomolecules, and biomolecule-nanoparticle conjugates for numerous applications. This review provides an overview of various types of biological nanoparticles and the methods of their fabrication with primary emphasis on the drying methods, particularly on the newly emerging technique, the electrospraying. Recent advances in the integration of biomolecules with nanoparticles in the past five years to present are also discussed. Finally, the application of the biomolecule-nanoparticle conjugates in various fields including medicals and pharmaceuticals, biosensors and bioelectronics, foods, and agricultures are also highlighted.

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Section: Methods To Synthesise Biological Nanoparticlesmentioning

confidence: 99%

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Saallah

Lenggoro

2018

KONA

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“…21,22 In the process of nanoparticle manufacture, all of the components, completely dissolved in suitable solvents, are sprayed into a stream of hot air to evaporate the solvent. 23 A polymeric nanosphere is a nano-sized, round-shaped structure in which the drug is uniformly distributed in the matrix. 14,15 Nanoparticulated solid dispersion is a promising way to overcome the problems pertaining to poor aqueous solubility, impaired dissolution rate, and low bioavailability of BCS class II drugs.…”

Section: Introductionmentioning

confidence: 99%

“…Nanospheres of solid dispersions can be prepared by spray drying a clear solution formed by completely dissolving all components in suitable solvents. 23 The term "nanocorpuscle" can be given to a nanoparticle having an irregular shape and/or surface.…”

Section: Introductionmentioning

confidence: 99%

Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

Yousaf¹,

Kim²,

Oh³

et al. 2015

IJN

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Background The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate. Methods The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w/v) aqueous solutions of each carrier. The polyvinylpyrrolidone (PVP) nanospheres, hydroxypropyl-β-cyclodextrin (HP-β-CD) nanocorpuscles, and gelatin nanocapsules were formulated as fenofibrate/PVP/sodium lauryl sulfate (SLS), fenofibrate/HP-β-CD, and fenofibrate/gelatin at the optimized weight ratios of 2.5:4.5:1, 1:4, and 1:8, respectively. The three solid-state products were achieved using the solvent-evaporation method through the spray-drying technique. The physicochemical characterization of these nanoparticles was accomplished by powder X-ray diffraction, differential scanning calorimetry, scanning electron microscopy, and Fourier-transform infrared spectroscopy. Their physicochemical properties, aqueous solubility, dissolution rate, and pharmacokinetics in rats were investigated in comparison with the drug powder. Results Among the tested carriers, PVP, HP-β-CD, gelatin, and SLS showed better solubility and were selected as the most appropriate constituents for various nanoparticulated systems. All of the formulations significantly improved the aqueous solubility, dissolution rate, and oral bioavailability of fenofibrate compared to the drug powder. The drug was present in the amorphous form in HP-β-CD nanocorpuscles; however, in other formulations, it existed in the crystalline state with a reduced intensity. The aqueous solubility and dissolution rates of the nanoparticles (after 30 minutes) were not significantly different from one another. Among the nanoparticulated systems tested in this study, the initial dissolution rates (up to 10 minutes) were higher with the PVP nanospheres and HP-β-CD nanocorpuscles; however, neither of them resulted in the highest oral bioavailability. Irrespective of relatively retarded dissolution rate, gelatin nanocapsules showed the highest apparent aqueous solubility and furnished the most improved oral bioavailability of the drug (~5.5-fold), owing to better wetting and diminution in crystallinity. Conclusion Fenofibrate-loaded gelatin nanocapsules prepared using the solvent-evaporation method through the spray-drying technique could be a potential oral pharmaceutical product for administering the poorly water-soluble fenofibrate with an enhanced bioavailability.

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“…If the drying is only partial, then some solvent may remain on the aerosols. The concentration of the solution/ suspension and other process parameters can be adjusted to control characteristics of the resulting aerosol, such as size, morphology, and density (Vehring et al 2007;Peltonen et al 2010;Nandiyanto and Okuyama 2011). Because of this degree of control, high number concentrations and particle sizes well below 100 nm are achievable.…”

Section: Introductionmentioning

confidence: 99%

A Cost-Effective Method of Aerosolizing Dry Powdered Nanoparticles

Tiwari

Fields

Marr

2013

Aerosol Science and Technology

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The ability to produce nanoscale aerosols from dry powdered material is needed for studies of the toxicity and environmental transformation and fate of manufactured nanoparticles. Wet aerosol generation methods can alter particle chemistry, while dry methods often cannot produce truly nanoscale aerosols. We have developed a cost-effective dry dispersion technique for manufactured nanoparticles and have demonstrated its use with C 60 fullerene, TiO 2 , and CeO 2 . The system disperses dry powders to create aerosols with mode diameters below 100 nm. Average mode and median diameters for each of the tested manufactured nanoparticles are 91 and 107 nm for C 60 , 65 and 77 nm for TiO 2 , and 40 and 43 nm for CeO 2 . All aerosols exhibit right-skewed unimodal distributions and irregular morphology. Aerosol mass concentrations produced by the dispersion system vary linearly with the mass of nanomaterial loaded into it and are of a magnitude appropriate for inhalation nanotoxicology studies. This work demonstrates the ability of a simple device to produce nanoscale aerosols from powdered engineered nanoparticles.

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Electrospraying, spray drying and related techniques for production and formulation of drug nanoparticles

Abstract: The most important advantage of these techniques as compared with many other particle formation techniques is that the production of dried powders is possible without any extra drying step.

Cited by 121 publications

References 114 publications

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Nanoparticles Carrying Biological Molecules: Recent Advances and Applications

Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation

A Cost-Effective Method of Aerosolizing Dry Powdered Nanoparticles

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