Electrospraying of environmentally sustainable alginate microbeads for cosmetic additives

Bae, Su Bin; Nam, Hyeong Chan; Park, Won Ho

doi:10.1016/j.ijbiomac.2019.04.058

Cited by 48 publications

(15 citation statements)

References 28 publications

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“…The swelling mechanism used here is closely linked to the Ca 2+ and Na + reversible ion-exchange reaction [50][51][52]. Recently, Bae et al (2019) reported the swelling ratio of alginate microbeads was abruptly increased in the presence of Na + ions reached in sea water media [53]. Here, larger swelling was observed as water freely penetrates the beads and fills the inert pores in the polymer chains.…”

Section: Bead Swelling Behaviourmentioning

confidence: 92%

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Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study

et al. 2020

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Black seed oil (BSO) has been used for various therapeutic purposes around the world since ancient eras. It is one of the most prominent oils used in nutraceutical formulations and daily consumption for its significant therapeutic value is common phenomena. The main aim of this study was to develop alginate-BSO beads as a controlled release system designed to control drug release in the gastrointestinal tract (GIT). Electrospray technology facilitates formulation of small and uniform beads with higher diffusion and swelling rates resulting in process performance improvement. The effect of different formulation and process variables was evaluated on the internal and external bead morphology, size, shape, encapsulation efficiency, swelling rate, in vitro drug release, release mechanism, ex vivo mucoadhesive strength and gastrointestinal tract qualitative and quantitative distribution. All the formulated beads showed small sizes of 0.58 ± 0.01 mm (F8) and spherical shape of 0.03 ± 0.00 mm. The coefficient of weight variation (%) ranged from 1.37 (F8) to 3.93 (F5) ng. All formulations (F1–F9) were studied in vitro for release characteristics and swelling behaviour, then the release data were fitted to various equations to determine the exponent (ns), swelling kinetic constant (ks), swelling rate (%/h), correlation coefficient (r2) and release kinetic mechanism. The oil encapsulation efficiency was almost complete at 90.13% ± 0.93% in dried beads. The maximum bead swelling rate showed 982.23 (F8, r2 = 0.996) in pH 6.8 and the drug release exceeded 90% in simulated gastrointestinal fluid (pH 6.8). Moreover, the beads were well distributed throughout various parts of the intestine. This designed formulation could possibly be advantageous in terms of increased bioavailability and targeted drug delivery to the intestine region and thus may find applications in some diseases like irritable bowel syndrome.

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Section: Bead Swelling Behaviourmentioning

confidence: 92%

“…This is consistent with the swelling character of BSO-loaded beads which outlines that the swelling index percentage of the beads increased in the SIF. This higher release rate could be attributed to the electrostatic repulsion among negatively charged carboxyl groups of alginates in the beads [54,55].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study

et al. 2020

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“…Hydrogels based on brown algae-derived alginate were regarded as alternative submucosal injection materials to hyaluronic acids, with the properties of durability, safety, and cost-effectiveness [ 320 ]. Alginate-based polymer microbeads were also prepared as environmentally friendly cosmetic additives to replace the non-biodegradable microparticles in exfoliation products [ 321 , 322 ]. The study showed that alginate polymer microbeads did not cause irritation, redness, itching, or dryness [ 322 ].…”

Section: Application Of Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Lin

Jiao²,

Kermanshahi-pour

2022

Marine Drugs

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Hydrogels are three-dimensional crosslinked hydrophilic polymer networks with great potential in drug delivery, tissue engineering, wound dressing, agrochemicals application, food packaging, and cosmetics. However, conventional synthetic polymer hydrogels may be hazardous and have poor biocompatibility and biodegradability. Algal polysaccharides are abundant natural products with biocompatible and biodegradable properties. Polysaccharides and their derivatives also possess unique features such as physicochemical properties, hydrophilicity, mechanical strength, and tunable functionality. As such, algal polysaccharides have been widely exploited as building blocks in the fabrication of polysaccharide-based hydrogels through physical and/or chemical crosslinking. In this review, we discuss the extraction and characterization of polysaccharides derived from algae. This review focuses on recent advances in synthesis and applications of algal polysaccharides-based hydrogels. Additionally, we discuss the techno-economic analyses of chitosan and acrylic acid-based hydrogels, drawing attention to the importance of such analyses for hydrogels. Finally, the future prospects of algal polysaccharides-based hydrogels are outlined.

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“…Another interesting compound is alginate, a PS obtained from brown seaweeds, that has been reported to form hydrogels in the presence of Ca 2+ ions that can be then shaped as microbeads, using electrospray, for being a biodegradable alternative to scrubbing additives in cleansers [74].…”

Section: Carotenoidsmentioning

confidence: 99%

Sustainable Sources from Aquatic Organisms for Cosmeceuticals Ingredients

et al. 2021

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Long life expectancy of populations in the developing world together with some cultural and social issues has driven the need to pay special attention to health and physical appearance. Cosmeceuticals are gaining interest in the cosmetic industry as their uses fulfills a double purpose: the requirements of a cosmetic (clean, perfume, protect, change the appearance of the external parts of the body or keeping them in good condition) with a particular bioactivity function. The cosmetics industry, producing both cosmetics and cosmeceuticals, is currently facing numerous challenges to satisfy different attitudes of consumers (vegetarianism, veganism, cultural or religious concerns, health or safety reasons, eco-friendly process, etc.). A currently growing trend in the market is the interest in products of low environmental impact. Marine origin ingredients are increasingly being incorporated into cosmeceutical preparations because they are able to address several consumer requirements and also due to the wide range of bioactivities they present (antioxidant, whitening, anti-aging, etc.). Many companies claim “Marine” as a distinctive marketing signal; however, only a few indicate whether they use sustainable ingredient sources. Sustainable marine ingredients might be obtained using wild marine biomass through a sustainable extractive fishing activity; by adopting valorization strategies including the use of fish discards and fish by-products; and by sustainably farming and culturing marine organisms.

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Electrospraying of environmentally sustainable alginate microbeads for cosmetic additives

Cited by 48 publications

References 28 publications

Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study

Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Sustainable Sources from Aquatic Organisms for Cosmeceuticals Ingredients

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