Electrospray mass spectrometry in the structural characterization of cephalosporins This paper is dedicated to the memory of Professor Dr Wilhelm J. Richter
Abstract:Six cephalosporins of pharmacological interest, cephalexin, cephuroxime, cephazolin, cephoperazone sodium salt, cephatrizin free acid and cephonicid disodium salt, were analysed by electrospray mass spectrometry. [M - Na]- anions were produced in high yield in the case of cephalexin, cephuroxime, cephazolin and cephoperazone, leading to signals at least two orders of magnitude more intense than those related to [M + Na]+ cations observed in the positive ion mode. In cephatrizin, [M - H]- represented the most a… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.