Electrospray ionization multistage tandem mass spectrometry of penta- and hexa-substituted aryloxycyclotriphosphazenes

Analysis of furo[3,2‐c]tetrahydroquinoline and pyrano[3,2‐c]tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry

“…First, moderate‐resolution and accurate mass measurements were achieved with an ESI‐Q‐TOF mass spectrometer to acquire the elemental compositions of the fragment ions . Second, multistage electrospray ionization (ESI‐MS n ) experiments in an ion trap instrument allowed us to understand the relationship between precursor and product ions . Third, hydrogen/deuterium (H/D) exchange reactions were employed to confirm the proposed structures of product ions and fragmentation routes .…”