Electrospray ionization mass spectrometry with wooden tips: A review

Hu, Bin; Yao, Zhongping

doi:10.1016/j.aca.2021.339136

Cited by 17 publications

(15 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Moreover, various solid substrates such as metal foil ( Hu et al, 2014 ), porous paper ( Cai et al, 2021 ), and biological tissue ( Hu et al, 2012 ), were used for direct loading raw samples, and then were performed ESI emitters ( Klampfl and Himmelsbach, 2015 ). Among these ambient ESI techniques, ESI on wooden tip is one of powerful ambient ESI techniques ( Hu et al, 2011 ; Hu and Yao, 2018 ; Ng et al, 2019 ; Millán-Santiago et al, 2022 ), provides a rapid method for rapid sampling and direct analysis of clinical samples ( Hu and Yao, 2022 ). By using wooden tip, wooden tip was directly used for loading raw samples, and organic solvent was then loaded on the sample to extract analytes and to generate spray ionization by applying a high voltage on wooden tip.…”

Section: Introductionmentioning

confidence: 99%

Determination of nicotine in newborn meconium by high-Resolution ambient mass spectrometry using wooden-Tip spray

et al. 2023

View full text Add to dashboard Cite

Prenatal exposure to nicotine that are mainly produced from tobacco smoke has been reported to affect infants. Therefore, nicotine exposure is one of important health concerns for newborn screening. Detecting nicotine and its metabolites such as cotinine in meconium were widely used to evaluate the tobacco exposure of pregnancy. In this study, disposable wooden tips were applied for touch sampling of meconium from newborn infants, and then were directly mounted on mass spectrometer (MS) to perform rapid screening of nicotine and cotinine. Choice of extraction/spray solvents was optimized. The limits of detection, reproducibility, linear response for direct analysis of meconium were also investigated. It is found the limits of detection (S/N = 3) to be as low as 0.36 ng/mg and 1.18 ng/mg for nicotine and cotinine, respectively, while the limits of quantitation (S/N = 10) to be 1.19 ng/mg and 3.94 ng/mg for nicotine and cotinine, respectively. The relative standard deviations (RSD) were found to be at 8.4%–19.8% (n = 6) for nicotine and cotinine, a good linear range from 5–500 ng/mL (R2 > 0.99). These analytical performances are well-accepted levels for ambient mass spectrometer analysis. In this study, evaluation of nicotine and cotinine in 22 puerpera volunteers were conducted by the established wooden-tip spray mass spectrometry (WTS-MS). These results showed that wooden-tip spray mass spectrometry would be useful for newborn screening of nicotine and cotinine in meconium with high reproducibility, speed, sensitivity, and specificity. Owing to the use of disposable wooden tips that involves no sample preparation and no chromatographic separation, our results show that wooden-tip spray mass spectrometry is a powerful tool for determination of nicotine in newborn meconium.

show abstract

Section: Introductionmentioning

confidence: 99%

Determination of nicotine in newborn meconium by high-Resolution ambient mass spectrometry using wooden-Tip spray

et al. 2023

View full text Add to dashboard Cite

show abstract

“…This technique allows the ionization of samples at atmospheric pressure. Ambient mass spectrometry can be broadly classified into three main classes based on their desorption methods 8 : desorption electrospray ionization (DESI), 9 extractive electrospray ionization (EESI), [10][11][12][13] and paper spray ionization (PSI) 14 ; plasma desorption including direct analysis in real time (DART), 15 desorption atmospheric pressure chemical ionization (DAPCI), [16][17][18] flowing atmospheric-pressure afterglow (FAPA), 19 microwave-induced plasma desorption/ionization (MIPDI), 20 dielectric barrier discharge ionization (DBDI), 21 and low temperature plasma (LTP) 22 ; the final is laser ablation including matrix-assisted laser desorption/ionization (MALDI) 23 and laser-ablation electrospray ionization (LAESI). 24 These techniques, with different ionization energies and polarity ranges, have been used to analyze different compounds.…”

Section: Introductionmentioning

confidence: 99%

Dual ambient plasma source ionization mass spectrometry for the rapid detection of trace sterols in urban water

2022

View full text Add to dashboard Cite

A direct analytical method based on dual ambient plasma ion source tandem mass spectrometry was used for the simultaneous determination of four sterols in the environment. This technology has very high sensitivity and the method detects the four sterols in methanol–water (1:3) solutions with limits of detection (LOD) and limits of quantification (LOQ) ranging from 1.2 ng/L to 6.9 ng/L and 7.6 ng/L to 10.0 ng/L, respectively. The method was also used to test water quality at three locations within the city and successfully detected all four sterols at very low concentrations. The dual plasma source tandem mass spectrometry technique is extremely simple, rapid, sensitive and highly efficient compared to other traditional methods, providing a useful screening tool for sterols in water.

show abstract

“…Recently, various ambient MS methods have been developed for various applications [16]. Remarkable analytical properties were found in ambient ESI with different substrates [19]. Paper spray ionization is one of the powerful ambient ESI techniques using porous paper substrate to load and ionize raw samples.…”

Section: Introductionmentioning

confidence: 99%

“…In the WT-ESI method, disposable and low-cost wooden tips are quite convenient for direct sampling and analysis without any hardware modifications. The wooden tip can be directly mounted on commercial nanoESI devices by replacing the nanoESI emitter [19,23], which is greatly beneficial for non-expert users, especially in clinical use. In general, raw samples can be directly loaded on the surface of a wooden tip under the strong electric field without the use of any gas.…”

Section: Introductionmentioning

confidence: 99%

Wooden-Tip Electrospray Mass Spectrometry Characterization of Human Hemoglobin in Whole Blood Sample for Thalassemia Screening: A Pilot Study

Huang

Zou

et al. 2022

Molecules

View full text Add to dashboard Cite

Traditional analytical methods for thalassemia screening are needed to process complicated and time-consuming sample pretreatment. In recent decades, ambient mass spectrometry (MS) approaches have been proven to be an effective analytical strategy for direct sample analysis. In this work, we applied ambient MS with wooden-tip electrospray ionization (WT-ESI) for the direct analysis of raw human blood samples that were pre-identified by gene detection. A total of 319 whole blood samples were investigated in this work, including 100 α-thalassemia carriers, 67 β-thalassemia carriers, and 152 control healthy samples. Only one microliter of raw blood sample was directly loaded onto the surface of the wooden tip, and then five microliters of organic solvent and a high voltage of +3.0 kV were applied onto the wooden tip to generate spray ionization. Multiply charged ions of human hemoglobin (Hb) were directly observed by WT-ESI-MS from raw blood samples. The signal ratios of Hb chains were used to characterize two main types of thalassemia (α and β types) and healthy control blood samples. Our results suggested that the ratios of charged ions to Hb chains being at +13 would be an indicator for β-thalassemia screening.

show abstract

Electrospray ionization mass spectrometry with wooden tips: A review

Cited by 17 publications

References 95 publications

Determination of nicotine in newborn meconium by high-Resolution ambient mass spectrometry using wooden-Tip spray

Determination of nicotine in newborn meconium by high-Resolution ambient mass spectrometry using wooden-Tip spray

Dual ambient plasma source ionization mass spectrometry for the rapid detection of trace sterols in urban water

Wooden-Tip Electrospray Mass Spectrometry Characterization of Human Hemoglobin in Whole Blood Sample for Thalassemia Screening: A Pilot Study

Contact Info

Product

Resources

About