Electrospray Encapsulation of Antithrombotic Drug into Poly (L-lactic acid) Nanoparticles for Cardiovascular Applications

Bakola, V.; Tsiapla, Aikaterini-Rafailia; Karagkiozaki, V.; Pappa, F.; Pavlidou, E.; Moutsios, Ioannis; Gravalidis, C.; Logothetidis, S.

doi:10.1016/j.matpr.2019.07.664

Cited by 9 publications

(5 citation statements)

References 18 publications

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“…Capsules prepared by ES have already found use in the field of drug delivery in the form of many interesting applications, including mucoadhesive systems for oral drug distribution [177], systems for delivering drugs or nutritional agents into the digestive tract [178], antithrombotic drug encapsulation systems [179], antimicrobial coatings of patches [180], and drug delivery microspheres for cancer therapy [181]. Additionally, using ES‐assisted approaches for the encapsulation of oligonucleotide [182] and DNA plasmids [183] has been reported to be an efficient strategy for gene delivery.…”

Section: Processing Of Polymersmentioning

confidence: 99%

Electrospray: More than just an ionization source

et al. 2020

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is a potential-driven process of liquid atomization, which is employed in the field of analytical chemistry, particularly as an ionization technique for mass spectrometric analyses of biomolecules. In this review, we demonstrate the extraordinary versatility of the electrospray by overviewing the specifics and advanced applications of ESbased processing of low molecular mass compounds, biomolecules, polymers, nanoparticles, and cells. Thus, under suitable experimental conditions, ES can be used as a powerful tool for highly controlled deposition of homogeneous films or various patterns, which may sometimes even be organized into 3D structures. We also emphasize its capacity to produce composite materials including encapsulation systems and polymeric fibers. Further, we present several other, less common ES-based applications. This review provides an insight into the remarkable potential of ES, which can be very useful in the designing of innovative and unique strategies.

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Section: Processing Of Polymersmentioning

confidence: 99%

Electrospray: More than just an ionization source

et al. 2020

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“…According to Gomez-Estaca et al, the electrospray technique or electrohydrodynamic atomization (EHDA) offers advantages for nanoparticle synthesis, including high encapsulation efficiency and no need for particle separation from the solvent [29]. Additionally, electrospray enables the formation of particles with varying diameters, uniform size distribution, and distinct morphologies [23], [30], [31]. This study also investigated the use of chitosan nanoparticles as drug carriers for cancer treatment using the electrospray technique.…”

Section: Introductionmentioning

confidence: 99%

Electrosprayed Chitosan Nanoparticles for Drug Carriers in Cancer Treatment - A Mini Review

Udaneni,

Azizah,

Harjunowibowo

et al. 2023

JBBBE

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Nanoparticles have emerged as promising tools for cancer treatment due to their ability to selectively deliver drugs to the tumor site while avoiding significant systemic side effects. Chitosan nanoparticles, among various types of nanoparticles, have gained significant attention due to their biocompatibility, biodegradability, and local drug delivery capacity. The electrospray technique is an efficient method for preparing chitosan nanoparticles, offering reproducibility, scalability, and high drug encapsulation efficiency. This technique has gained popularity due to its ease of use and flexibility in meeting various demands of nanoparticle production. Recent studies have investigated the potential of chitosan nanoparticles prepared by electrospray technique to encapsulate a range of drugs. The method leverages active surface absorption, binding, or complexation with drugs. For example, chitosan-based nanoparticles loaded with DOX and QUE achieved high encapsulation efficiency of 83% and effectively inhibited the growth of HCT-116 cancer cells. Similarly, SNP-CH-DOX-CM nanoparticles showed significant anti-cancer activity against HepG2 tumors. However, it should be noted that the toxicity of nanoparticles is directly related to the concentration of the active substance. Therefore, careful optimization of drug dosing is necessary to minimize any potential toxicity.

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“… 227 To address the problem of late stent thrombosis, an antiplatelet drug dipyridamole was loaded within PLA NPs, which showed a sustained drug release over 1 month in vitro. 228 Stents coated with PLGA/chitosan nanoparticles containing a fluorescence marker (FITC) after 4 weeks of implantation in porcine coronary artery led to the specific uptake of these NPs by SMCs, yielding FITC fluorescence in the neointimal and medial layers of the stented artery in comparison with bare. However, the extent of neointima formation and re-endothelialization was comparable for the bare-metal and NP-eluting stents.…”

Section: Introductionmentioning

confidence: 99%

Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy

et al. 2021

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Coronary in-stent restenosis and late stent thrombosis are the two major inadequacies of vascular stents that limit its long-term efficacy. Although restenosis has been successfully inhibited through the use of the current clinical drug-eluting stent which releases antiproliferative drugs, problems of late-stent thrombosis remain a concern due to polymer hypersensitivity and delayed re-endothelialization. Thus, the field of coronary stenting demands devices having enhanced compatibility and effectiveness to endothelial cells. Nanotechnology allows for efficient modulation of surface roughness, chemistry, feature size, and drug/biologics loading, to attain the desired biological response. Hence, surface topographical modification at the nanoscale is a plausible strategy to improve stent performance by utilizing novel design schemes that incorporate nanofeatures via the use of nanostructures, particles, or fibers, with or without the use of drugs/biologics. The main intent of this review is to deliberate on the impact of nanotechnology approaches for stent design and development and the recent advancements in this field on vascular stent performance.

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Electrospray Encapsulation of Antithrombotic Drug into Poly (L-lactic acid) Nanoparticles for Cardiovascular Applications

Cited by 9 publications

References 18 publications

Electrospray: More than just an ionization source

Electrospray: More than just an ionization source

Electrosprayed Chitosan Nanoparticles for Drug Carriers in Cancer Treatment - A Mini Review

Surface engineering at the nanoscale: A way forward to improve coronary stent efficacy

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