Electrospray deposited plant-based polymer nanocomposite coatings with enhanced antibacterial activity for Ti-6Al-4V implants

Yontar, Arife Kübra; Çevik, Sinem

doi:10.1016/j.porgcoat.2023.107965

Cited by 5 publications

(2 citation statements)

References 110 publications

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“…In this section, we describe recent advances and report on the most used coating techniques, including electrochemical deposition, layer-by-layer coating, and spin coating [ 6 , 7 , 98 ]. Here, electrospray deposition [ 99 , 100 ], electrospinning [ 75 , 101 ], and electrophoretic deposition [ 102 , 103 ] are promising tools for developing biocompatible and antibacterial coatings on orthopedic implants, including multifunctional coatings.…”

Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Akay,

Yaghmur

2024

Molecules

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Implant-associated infections (IAIs) represent a major health burden due to the complex structural features of biofilms and their inherent tolerance to antimicrobial agents and the immune system. Thus, the viable options to eradicate biofilms embedded on medical implants are surgical operations and long-term and repeated antibiotic courses. Recent years have witnessed a growing interest in the development of robust and reliable strategies for prevention and treatment of IAIs. In particular, it seems promising to develop materials with anti-biofouling and antibacterial properties for combating IAIs on implants. In this contribution, we exclusively focus on recent advances in the development of modified and functionalized implant surfaces for inhibiting bacterial attachment and eventually biofilm formation on orthopedic implants. Further, we highlight recent progress in the development of antibacterial coatings (including self-assembled nanocoatings) for preventing biofilm formation on orthopedic implants. Among the recently introduced approaches for development of efficient and durable antibacterial coatings, we focus on the use of safe and biocompatible materials with excellent antibacterial activities for local delivery of combinatorial antimicrobial agents for preventing and treating IAIs and overcoming antimicrobial resistance.

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Section: Biofilm Formation On Orthopedic Implants and Prevention Stra...mentioning

confidence: 99%

Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Akay,

Yaghmur

2024

Molecules

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“…Inflammation is a common response after implantation, which can hinder proper healing and the integration of the implant. Certain plant extracts have demonstrated anti-inflammatory properties by modulating inflammatory pathways and reducing inflammatory markers [19,20]. Thin-film coatings containing these extracts can help minimize inflammation at the implant site and promote better healing.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Biocompatibility Study on Functional Nanostructures Containing Bioactive Glass and Plant Extracts for Implantology

Floroian,

Badea

2024

IJMS

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In this paper, the in vivo behavior of orthopedic implants covered with thin films obtained by matrix-assisted pulsed laser evaporation and containing bioactive glass, a polymer, and natural plant extract was evaluated. In vivo testing was performed by carrying out a study on guinea pigs who had coated metallic screws inserted in them and also controls, following the regulations of European laws regarding the use of animals in scientific studies. After 26 weeks from implantation, the guinea pigs were subjected to X-ray analyses to observe the evolution of osteointegration over time; the guinea pigs’ blood was collected for the detection of enzymatic activity and to measure values for urea, creatinine, blood glucose, alkaline phosphatase, pancreatic amylase, total protein, and glutamate pyruvate transaminase to see the extent to which the body was affected by the introduction of the implant. Moreover, a histopathological assessment of the following vital organs was carried out: heart, brain, liver, and spleen. We also assessed implanted bone with adjacent tissue. Our studies did not find significant variations in biochemical and histological results compared to the control group or significant adverse effects caused by the implant coating in terms of tissue compatibility, inflammatory reactions, and systemic effects.

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Bio-Synthesized Silver Nanoparticles Using Cannabis Sativa Seed Extracts and Its Anticancer Effects

Yontar,

Çevik

2023

Plasmonics

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Electrospray deposited plant-based polymer nanocomposite coatings with enhanced antibacterial activity for Ti-6Al-4V implants

Cited by 5 publications

References 110 publications

Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

Recent Advances in Antibacterial Coatings to Combat Orthopedic Implant-Associated Infections

In Vivo Biocompatibility Study on Functional Nanostructures Containing Bioactive Glass and Plant Extracts for Implantology

Bio-Synthesized Silver Nanoparticles Using Cannabis Sativa Seed Extracts and Its Anticancer Effects

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