Electrospinning tissue engineering and wound dressing scaffolds from polymer-titanium dioxide nanocomposites

Ghosal, Kajal; Agatemor, Christian; Špitálský, Zdenko; Thomas, Sabu; Kny, E.

doi:10.1016/j.cej.2018.10.117

Cited by 207 publications

(107 citation statements)

References 132 publications

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“…Generally, electrospun wound dressings are fabricated through a typical electrospinning process to obtain membrane materials. Electrospinning solutions were prepared by dissolving single polymers or by blending natural and synthetic polymers; in some cases, the antibacterial substances could be directly mixed into the solutions [64,65]. Moreover, the healing of skin wounds is a complex biological process.…”

Section: Electrospun Scaffolds For Wound Dressing Applicationmentioning

confidence: 99%

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

et al. 2019

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Electrospinning technologies have been applied in the field of tissue engineering as materials, with nanoscale-structures and high porosity, can be easily prepared via this method to bio-mimic the natural extracellular matrix (ECM). Tissue engineering aims to fabricate functional biomaterials for the repairment and regeneration of defective tissue. In addition to the structural simulation for accelerating the repair process and achieving a high-quality regeneration, the combination of biomaterials and bioactive molecules is required for an ideal tissue-engineering scaffold. Due to the diversity in materials and method selection for electrospinning, a great flexibility in drug delivery systems can be achieved. Various drugs including antibiotic agents, vitamins, peptides, and proteins can be incorporated into electrospun scaffolds using different electrospinning techniques and drug-loading methods. This is a review of recent research on electrospun nanofibrous scaffolds for tissue-engineering applications, the development of preparation methods, and the delivery of various bioactive molecules. These studies are based on the fabrication of electrospun biomaterials for the repair of blood vessels, nerve tissues, cartilage, bone defects, and the treatment of aneurysms and skin wounds, as well as their applications related to oral mucosa and dental fields. In these studies, due to the optimal selection of drugs and loading methods based on electrospinning, in vitro and in vivo experiments demonstrated that these scaffolds exhibited desirable effects for the repair and treatment of damaged tissue and, thus, have excellent potential for clinical application.

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Section: Electrospun Scaffolds For Wound Dressing Applicationmentioning

confidence: 99%

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

et al. 2019

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“…Due to their inherent material properties, these mats not only provide a three-dimensional structure but are also biocompatible, bioabsorbable, and have antibacterial properties, making them extremely desirable for use in scaffolds and medical devices (Roux et al, 2013;Stocco et al, 2018). PLA/TiO 2 -nanofibrous fibers produced by electrospinning are being studied in order to evaluate their potential in dressing and wound healing applications (Bayon et al, 2016;Toniatto et al, 2017;Ghosal et al, 2018;Salles et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibrous Poly (Lactic Acid)/Titanium Dioxide Nanocomposite Membranes for Cutaneous Scar Minimization

Marsi

Ricci

Toniato

et al. 2019

Front. Bioeng. Biotechnol.

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Poly (lactic acid) (PLA) has been increasingly used in cutaneous tissue engineering due to its low cost, ease of handling, biodegradability, and biocompatibility, as well as its ability to form composites. However, these polymers possess a structure with nanoporous that mimic the cellular environment. In this study, nanocomposites are prepared using PLA and titanium dioxide (TiO 2) (10 and 35%-w/w) nanoparticles that also function as an active anti-scarring agent. The nanocomposites were prepared using an electrospinning technique. Three different solutions were prepared as follows: PLA, 10% PLA/TiO 2 , and 35% PLA/TiO 2 (w/w%). Electrospun PLA and PLA/TiO 2 nanocomposites were characterized morphologically, structurally, and chemically using electron scanning microscopy, transmission electron microscopy, goniometry, and X-ray diffraction. L929 fibroblast cells were used for in vitro tests. The cytotoxic effect was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays. Versicam (VCAN), biglicam (BIG), interleukin-6 (IL6), interleukin-10 (IL-10), and type-1 collagen (COL1A1) genes were evaluated by RT-qPCR. In vivo tests using Wistar rats were conducted for up to 15 days. Nanofibrous fibers were obtained for all groups that did not contain residual solvents. No cytotoxic effects were observed for up to 168 h. The genes expressed showed the highest values of versican and collagen-1 (p < 0.05) for PLA/TiO 2 nanocomposite scaffolds when compared to the control group (cells). Histological images showed that PLA at 10 and 35% w/w led to a discrete inflammatory infiltration and expression of many newly formed vessels, indicating increased metabolic activity of this tissue. To summarize, this study supported the potential of PLA/TiO 2 nanocomposites ability to reduce cutaneous scarring in scaffolds.

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“…Currently, wound dressings or artificial skins produced by advanced technologies have been extensively studied in the wound treatment since decades. [6][7][8][9][10][11] Among them, the electrospinning technology that can produce nanofibers to simulate the nanoscale structure of native extracellular matrix presents many incomparable advantages, such as nanoscaled porous structures permitting water and oxygen exchange, appropriate flexibility, easily carrying cell instructive and conductive cues. [12][13][14] So far, large quantities of natural and synthetic polymers, such as collagen, silk fibrin (SF), gelatin, polysaccharides, poly(vinyl alcohol) (PVA), poly(lactic acid) (PLA), poly(lactic-co-glycolic acid) (PLGA), and polycaprolactone (PCL) have been extensively used to produce electrospun nanofibers for wounding healing.…”

Section: Introductionmentioning

confidence: 99%

High Flexible and Broad Antibacterial Nanodressing Induces Complete Skin Repair with Angiogenic and Follicle Regeneration

Wang

Zha

et al. 2020

Adv Healthcare Materials

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Complete skin reconstruction is a hierarchically physiological assembly involving epidermis, dermis, vasculature, innervation, hair follicles, and sweat glands. Despite various wound dressings having been developed for skin regeneration, few works refer to the complete skin regeneration, particularly lacking for vasculatures and hair follicles. Herein, an instructive wound dressing that integrates the antibacterial property of quaternized chitin and the mechanical strength and biological multifunction of silk fibroin through layer-by-layer electrostatic self-assembly is designed and reported. The resultant dressings exhibit a nanofibrous structure ranging from 471.5 ± 212.1 to 756.9 ± 241.8 nm, suitable flexibility with tensile strength up to 4.47 ± 0.29 MPa, and broad-spectrum antibacterial activity against Escherichia coli and Staphylococcus aureus. More interestingly, the current dressing system remarkably accelerates in vivo vascular reconstruction within 15 days, and the number of regenerated hair follicles reaches up to 22 ± 4 mm −2 , which is comparable to the normal tissue (27 ± 2 mm −2). Those crucial functions might originate from the combination between quaternized chitin and silk fibroin and the hierarchical structure of electrospun nanofiber. This work establishes an easy but effective pathway to design a multifunctional wound dressing for the complete skin regeneration.

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Electrospinning tissue engineering and wound dressing scaffolds from polymer-titanium dioxide nanocomposites

Cited by 207 publications

References 132 publications

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release

Electrospun Nanofibrous Poly (Lactic Acid)/Titanium Dioxide Nanocomposite Membranes for Cutaneous Scar Minimization

High Flexible and Broad Antibacterial Nanodressing Induces Complete Skin Repair with Angiogenic and Follicle Regeneration

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