Electrospinning Technologies in Wound Dressing Applications

Sandri, Giuseppina; Rossi, Silvia; Caramella, Carla; Ferrari, Franca

doi:10.1002/9781119433316.ch14

Cited by 25 publications

(25 citation statements)

References 56 publications

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“…Electrospinning is a method that allows the generation of nanofibrous porous scaffolds using a high voltage electric field. It is a simple, versatile, flexible, and cost-effective method to spin polymeric materials to generate ultra-thin fibers with diameters in the nanometric or micrometric range [ 72 , 73 ].…”

Section: New Strategies For the Treatment Of Injuries: Tissue Engimentioning

confidence: 99%

Innovative Strategies in Tendon Tissue Engineering

et al. 2021

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The tendon is a highly aligned connective tissue that transmits force from muscle to bone. Each year, more than 32 million tendon injuries have been reported, in fact, tendinopathies represent at least 50% of all sports injuries, and their incidence rates have increased in recent decades due to the aging population. Current clinical grafts used in tendon treatment are subject to several restrictions and there is a significant demand for alternative engineered tissue. For this reason, innovative strategies need to be explored. Tendon replacement and regeneration are complex since scaffolds need to guarantee an adequate hierarchical structured morphology and mechanical properties to stand the load. Moreover, to guide cell proliferation and growth, scaffolds should provide a fibrous network that mimics the collagen arrangement of the extracellular matrix in the tendons. This review focuses on tendon repair and regeneration. Particular attention has been devoted to the innovative approaches in tissue engineering. Advanced manufacturing techniques, such as electrospinning, soft lithography, and three-dimensional (3D) printing, have been described. Furthermore, biological augmentation has been considered, as an emerging strategy with great therapeutic potential.

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Section: New Strategies For the Treatment Of Injuries: Tissue Engimentioning

confidence: 99%

Innovative Strategies in Tendon Tissue Engineering

et al. 2021

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“…Therefore, MMT or HNT could conceivably reduce the interfacial tension in the polymer blend, thus facilitating electrospinning, to obtain finer and more homogeneous nanofibers with respect to the blank [22]. Moreover, it is reported that the conductivity of the solution, influenced by the clay content, could increase the charge on the surface of the droplet to form a Taylor cone, and consequently could cause the decrease in the fiber diameter [23].…”

Section: Samplementioning

confidence: 99%

Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing

et al. 2020

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The increase in life expectancy and the increasing prevalence of diabetic disease and venous insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in the adult population to 3–5% in the over 65 years population, with 3–5.5% of the total healthcare expenditure, as recently estimated. The aim of this work was the design and the development of electrospun scaffolds, entirely based on biopolymers, loaded with montmorillonite (MMT) or halloysite (HNT) and intended for skin reparation and regeneration, as a 3D substrate mimicking the dermal ECM. The scaffolds were manufactured by means of electrospinning and were characterized for their chemico-physical and preclinical properties. The scaffolds proved to possess the capability to enhance fibroblast cells attachment and proliferation with negligible proinflammatory activity. The capability to facilitate the cell adhesion is probably due to their unique 3D structure which are assisting cell homing and would facilitate wound healing in vivo.

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“…Different techniques are used for the manufacture of nanofibers such as centrifugal spinning, the direct drawing technique, and electrospinning [ 61 ] ( Figure 1 ). In particular, electrospinning is a simple and versatile technique used in continuous manufacturing, extremely pushed by regulatory agencies to improve product quality; moreover it is considered an advanced, easily scalable, and emerging technology, leading to improvements in terms of new product properties, production speed, cost, and waste and pollution management [ 62 ].…”

Section: Medical Devices For Wound Healingmentioning

confidence: 99%

“…Native skin shows tensile strength values between 5.0 and 30.0 MPa, a Young’s modulus in the range of 4.6–20.0 MPa and elongation at break of about 35.0–115.0%; these values are wide since the skin mechanical properties vary depending on the body area, and the ageing (thinner and less flexible [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 ]). The ability of the scaffold to maintain its integrity during grafting is related to the tensile strength, while the performance of the scaffold upon grafting is related to elongation and the Young’s modulus.…”

Section: Definition Of the Quality Attributesmentioning

confidence: 99%

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Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

et al. 2020

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Chronic wounds, such as pressure ulcers, diabetic ulcers, venous ulcers and arterial insufficiency ulcers, are lesions that fail to proceed through the normal healing process within a period of 12 weeks. The treatment of skin chronic wounds still represents a great challenge. Wound medical devices (MDs) range from conventional and advanced dressings, up to skin grafts, but none of these are generally recognized as a gold standard. Based on recent developments, this paper reviews nanotechnology-based medical devices intended as skin substitutes. In particular, nanofibrous scaffolds are promising platforms for wound healing, especially due to their similarity to the extracellular matrix (ECM) and their capability to promote cell adhesion and proliferation, and to restore skin integrity, when grafted into the wound site. Nanotechnology-based scaffolds are emphasized here. The discussion will be focused on the definition of critical quality attributes (chemical and physical characterization, stability, particle size, surface properties, release of nanoparticles from MDs, sterility and apyrogenicity), the preclinical evaluation (biocompatibility testing, alternative in vitro tests for irritation and sensitization, wound healing test and animal wound models), the clinical evaluation and the CE (European Conformity) marking of nanotechnology-based MDs.

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Electrospinning Technologies in Wound Dressing Applications

Cited by 25 publications

References 56 publications

Innovative Strategies in Tendon Tissue Engineering

Innovative Strategies in Tendon Tissue Engineering

Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing

Nanotechnology-Based Medical Devices for the Treatment of Chronic Skin Lesions: From Research to the Clinic

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