Electrospinning polyvinylidene fluoride fibrous membranes containing anti-bacterial drugs used as wound dressing

He, Ting; Wang, Jingnan; Huang, Peilin; Zeng, Baozhen; Li, Haihong; Cao, Qingqing; Zhang, Shiying; Luo, Zhifeng; Deng, David Y.B.; Zhang, Hongwu; Zhou, Wuyi

doi:10.1016/j.colsurfb.2015.04.026

Cited by 85 publications

(47 citation statements)

References 30 publications

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“…18,19 Electrospinning is a simple and highly versatile method to produce bers in nanometer size with many special properties, such as smaller pores and higher surface area than that of the regular bers, 20 and this particular structure is favorable for the sustained release of antimicrobial substances from the packaging lm to the food surface. 21 The electrospinning technology is now well established in several elds, such as ltration, 22 wound dressing, 23 drug delivery, 24 tissue engineering, 25 etc. However, its potential use in the eld of food science has been less explored.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of the antimicrobial activity of cinnamon essential oil-loaded electrospun nanofilm by the incorporation of lysozyme

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Enhancement of the antimicrobial activity of cinnamon essential oil-loaded electrospun nanofilm by the incorporation of lysozyme

et al. 2017

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“…After measuring the absorbance, the solution was returned to the centrifuge tube to ensure the constant volume of the release solution. The release percentage (Equation ) and accumulative release percentage (Equation ) were calculated by the following equations

R P i (%) = \frac{C i \times V}{W_{0}} \times 100 %

A R i (%) = \sum_{i = 1}^{i} R P i

where RPi is release percentage determined at different observation time ( i ); ARi is accumulative release; Ci is drug concentration; V is volume; and W 0 is total entrapped drug.…”

Section: Methodsmentioning

confidence: 99%

Silk Fibroin‐Based Fibrous Anal Fistula Plug with Drug Delivery Function

Xie

Liu

Zheng

et al. 2018

Macromolecular Bioscience

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The aim of this work is to develop a drug-loaded silk fibroin fibrous membrane (DSFM) that can be attached to the surface of an anal fistula plug to improve the treatment of Crohn's disease (CD). Curcumin (CUR) and 5-aminosalicylic acid (5-ASA)-loaded silk fibroin (SF) membranes are coaxially electrospun onto the surface of a braided silk filament plug. The membranes show a predominant structure of random coil and silk I conformation. The concentration of CUR/5-ASA (weight ratio of 1/1) in the SF solution is optimized to 0.4, 0.9, and 1.9 wt%. The morphologies, secondary structures, and in vitro drug release properties of the membranes are examined. Sectional images of fibers in the membranes show core-shell structures. The coaxial electrospinning process does not alter the chemical characteristics of the drugs. The dual-drugs encapsulated in the membranes are released in a steady and sustainable manner, and the cumulative release rate is improved by the increased drug loading. The membranes exhibit no cytotoxicity, thereafter increase the viability of human fibroblasts on the DSFMs. These SF membranes with core-shell structure and functional encapsulation of CUR and 5-ASA should be useful for further studies toward the treatment of CD.

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“…Electrospun fibrous mats have been extensively researched as wound dressings capable of imparting anti-bacterial attributes to the wound as well as regenerative properties [107,108]. Such wound dressings can be used as media to deliver analgesics and antibiotics such topical anesthesia and which can decrease the amount of systemic administration of these drugs needed and hence help in decreasing their many unwanted adverse effects.…”

Section: Electrospun Nanofibers For Dental Applicationsmentioning

confidence: 99%

Potential of Electrospun Nanofibers for Biomedical and Dental Applications

et al. 2016

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Electrospinning is a versatile technique that has gained popularity for various biomedical applications in recent years. Electrospinning is being used for fabricating nanofibers for various biomedical and dental applications such as tooth regeneration, wound healing and prevention of dental caries. Electrospun materials have the benefits of unique properties for instance, high surface area to volume ratio, enhanced cellular interactions, protein absorption to facilitate binding sites for cell receptors. Extensive research has been conducted to explore the potential of electrospun nanofibers for repair and regeneration of various dental and oral tissues including dental pulp, dentin, periodontal tissues, oral mucosa and skeletal tissues. However, there are a few limitations of electrospinning hindering the progress of these materials to practical or clinical applications. In terms of biomaterials aspects, the better understanding of controlled fabrication, properties and functioning of electrospun materials is required to overcome the limitations. More in vivo studies are definitely required to evaluate the biocompatibility of electrospun scaffolds. Furthermore, mechanical properties of such scaffolds should be enhanced so that they resist mechanical stresses during tissue regeneration applications. The objective of this article is to review the current progress of electrospun nanofibers for biomedical and dental applications. In addition, various aspects of electrospun materials in relation to potential dental applications have been discussed.

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Electrospinning polyvinylidene fluoride fibrous membranes containing anti-bacterial drugs used as wound dressing

Cited by 85 publications

References 30 publications

Enhancement of the antimicrobial activity of cinnamon essential oil-loaded electrospun nanofilm by the incorporation of lysozyme

Enhancement of the antimicrobial activity of cinnamon essential oil-loaded electrospun nanofilm by the incorporation of lysozyme

Silk Fibroin‐Based Fibrous Anal Fistula Plug with Drug Delivery Function

Potential of Electrospun Nanofibers for Biomedical and Dental Applications

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