Electrospinning of ultrafine core/shell fibers for biomedical applications

Zhang, Hong; Zhao, Chenguang; Zhao, Yunhui; Tang, Gongwen; Yuan, Xiaoyan

doi:10.1007/s11426-010-3180-3

Cited by 62 publications

(46 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This method is commonly used to encapsulate a hydrophilic drug into a hydrophobic polymer shell [92]. Since the encapsulated factor may contact organic solvents in the emulsion, co-axial electrospinning is safer for protein delivery [93]. Coaxial electrospinning employs a dual needle apparatus where a soluble inner core solution is spun within a polymer solution shell [94].…”

Section: Methods Of Deliverymentioning

confidence: 99%

Integration of drug, protein, and gene delivery systems with regenerative medicine

Lorden

Levinson

Leong

2013

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

Regenerative medicine has the potential to drastically change the field of health care from reactive to preventative and restorative. Exciting advances in stem cell biology and cellular reprogramming have fueled the progress of this field. Biochemical cues in the form of small molecule drugs, growth factors, zinc finger protein transcription factors and nucleases, transcription activator-like effector nucleases, monoclonal antibodies, plasmid DNA, aptamers, or RNA interference agents can play an important role to influence stem cell differentiation and the outcome of tissue regeneration. Many of these biochemical factors are fragile and must act intracellularly at the molecular level. They require an effective delivery system, which can take the form of a scaffold (e.g. hydrogels and electrospun fibers), carrier (viral and nonviral), nano- and micro-particle, or genetically modified cell. In this review, we will discuss the history and current technologies of drug, protein and gene delivery in the context of regenerative medicine. Next we will present case examples of how delivery technologies are being applied to promote angiogenesis in non-healing wounds or prevent angiogenesis in age related macular degeneration. Finally, we will conclude with a brief discussion of the regulatory pathway from bench-to-bedside for the clinical translation of these novel therapeutics.

show abstract

Section: Methods Of Deliverymentioning

confidence: 99%

Integration of drug, protein, and gene delivery systems with regenerative medicine

Lorden

Levinson

Leong

2013

Drug Deliv. and Transl. Res.

View full text Add to dashboard Cite

show abstract

“…1,2 Because the process of coaxial electrospinning is similar to conventional electrospinning, the same solution and process variables affect the morphology of the core-shell fibers. Several useful properties, such as a highsurface-area-to-volume ratio, flexibility in surface functionality, and excellent mechanical properties, can be achieved when the diameter of the polymer fiber is reduced to the nanoscale.…”

Section: Introductionmentioning

confidence: 99%

“…Modifications of conventional electrospinning have emerged for the preparation of ultrafine core-shell fibers. 1 The first coaxial electrospinning was presented by Sun et al 5 They illustrated that the short time of the electrospinning process prevents the two miscible solutions from mixing significantly. 1,2 Because the process of coaxial electrospinning is similar to conventional electrospinning, the same solution and process variables affect the morphology of the core-shell fibers.…”

Section: Introductionmentioning

confidence: 99%

Preparation and properties of antibacterial, biocompatible core–shell fibers produced by coaxial electrospinning

Khodkar

Ebrahimi

2017

J of Applied Polymer Sci

View full text Add to dashboard Cite

Coaxial electrospinning is a method for producing fibrous mats with optional features, such as antibacterial properties, controllable release, and hydrophobicity based on shell materials. Because these features are important in biomedical applications, in this study, biocompatible hydrophobic polymer (polycaprolactone) and hydrophilic polymer [poly(vinyl alcohol)] with silver nanoparticles loaded in the core solution were coaxially electrospun. The effect of silver addition on the conductivity and viscosity of the solutions, chemical structure of the fiber mats, mechanical properties, porosity, hydrophobicity, water vapor transmission rate (WVTR), silver release, and antibacterial properties were investigated. Fibers with silver exhibited less porosity and a lower WVTR and a greater contact angle than the fibers without silver. Furthermore, the core-shell fibers reduced the burst release of silver and successfully prevented the growth of Escherichia coli and Staphylococcus aureus bacteria. Therefore, it seems that these fibers are suitable for providing electrospun mats with long-term antibacterial properties.

show abstract

“…1) [11]. Like during the standard electrospinning process, shortly after passing the nozzle, under optimal conditions, Taylor cone is created (double cone in coaxial electrospin).…”

Section: Introductionmentioning

confidence: 99%

Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine

Hudecki

Gola

Ghavami

et al. 2017

Preprint

View full text Add to dashboard Cite

SummaryWe investigated the structure and properties of PCL 10 nanofiber, PCL 5 /PCL 10 core-shell type nanofibers, as well as PCL 5 /PCL Ag nanofibres prepared by electrospinning. For the production of the fibre variants, a 5-10% solution of polycaprolactone (M w = 70000-90000), dissolved in a mixture of formic acid and acetic acid at a ratio of 70:30 m/m was used. In order to obtain fibres containing PCL Ag 1% of silver nanoparticles was added. The electrospin was conducted using the above-described solutions at the electrostatic field. The subsequent bio-analysis shows that synthesis of core-shell nanofibers PCL 5 /PCL 10 , and the silver-doped variant nanofiber core shell PCL 5 /PCL Ag by using organic acids as solvents is a robust technique. Such way obtained nanofibres may then be used in regenerative medicine for extracellular scaffolds: (i) for controlled bone regeneration due to the long decay time of the PCL, (ii) and as carriers of drug delivery nanocapsules. Furthermore, the used solvents are significantly less toxic than the solvents for polycaprolactone currently commonly used in electrospin, like for example chloroform (CHCl 3 ), methanol (CH 3 OH), dimethylformamide (C 3 H 7 NO) or tetrahyfrofurna (C 4 H 8 O), hence the presented here electrospin technique may allow for the production of multilayer nanofibres more suitable for the use in medical field.

show abstract

Electrospinning of ultrafine core/shell fibers for biomedical applications

Cited by 62 publications

References 100 publications

Integration of drug, protein, and gene delivery systems with regenerative medicine

Integration of drug, protein, and gene delivery systems with regenerative medicine

Preparation and properties of antibacterial, biocompatible core–shell fibers produced by coaxial electrospinning

Structure and properties of slow-resorbing nanofibers obtained by (co-axial) electrospinning as tissue scaffolds in regenerative medicine

Contact Info

Product

Resources

About