Electrospinning of thermoplastic carboxymethyl cellulose/poly(ethylene oxide) nanofibers for use in drug-release systems

Esmaeili, Akbar; Haseli, Mahsa

doi:10.1016/j.msec.2017.03.252

Cited by 68 publications

(49 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2014, Amirah et al encapsulated RIF in poly (3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) under different conditions. In that study, the highest encapsulation efficiency achieved was 26.5% . In 2015, doxorubicin was successfully loaded onto nanoparticles at a level of 75% …”

Section: Resultsmentioning

confidence: 99%

“…In these systems, drugs are carried by special vehicles such as natural and synthetic polymers, organic/inorganic hybrid materials, and nanoparticles. Magnetic particles are used in biology and medicine for such purposes as magnetic resonance imaging, RNA and DNA purification, enzyme and protein immobilization, and delivery of anticancer drugs . Fe 3 O 4 nanoparticles, chemically stable and easily obtained, are widely applied in drug delivery.…”

Section: Introductionmentioning

confidence: 99%

“…These shells are either biocompatible or have active groups that can be conjugated to biomolecules or drugs. Studies have indicated that addition of ascorbic acid as a stabilizing agent in delivery of RIF can minimize RIF degradation and increase its bioavailability . In 2002, Ming Ma et al loaded biomolecules and drugs on activated Fe 3 O 4 nanoparticles with a layer of amino silane with active amino groups .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Esmaeili

Khodaei

2017

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

Rifampin (RIF) is a bactericidal antibiotic drug and potent inducer of hepatic and intestinal cytochrome P-450 (CYP-450) enzyme systems. Given by mouth or intravenously, it can cause numerous clinical drug interactions; thus, alternative systems of drug delivery that bypass some or all of its toxic effects are well worth investigating. In this study, a controlled layer-by-layer (LBL) process of encapsulating RIF in biocompatible alginate and chitosan polymers loaded onto Fe O nanoparticles was developed. Fe O nanoparticles were synthesized from FeCl ·6H O using a hydrothermal procedure. Fluorescent molecular beacons containing RIF molecules and Texas Red were loaded onto the surfaces of Fe O nanoparticles. The loaded nanoparticles were encapsulated in alginate and chitosan layers with alternating negative and positive surface charge using an LBL self-assembly method. Subsequently, by removing the Fe O template particles, polymeric capsules containing RIF were obtained. Ultraviolet-visible spectrophotometry employed to determine optimized conditions for loading RIF, measure the amount of RIF loaded onto the surface of the nanoparticles under optimized conditions, and study drug-release capability. Scanning electron microscopy was used to characterize the morphology of unloaded and loaded nanoparticles. X-ray diffraction and Fourier transform infrared spectroscopy were applied to demonstrate the production of nanoparticles and loading of RIF onto them. Zeta potential analysis was used to determine the size and surface potential of the loaded polymeric layers. After removal of the core template, confocal fluorescence microscopy was used to isolate polymeric capsules containing RIF. The average size of the nanoparticles obtained was 23 nm. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 905-913, 2018.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Esmaeili

Khodaei

2017

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…Composite membrane with dimension of 2 cm × 2 cm was cut and arrayed at different times (4,8,12,16,20,24,28, 32, 36 min) with 5 M urea solution. About 3 mL, Nessler reagent was added to the urea solution.…”

Section: Decomposition Of Urea and Measurement Of Ammonia Concentratimentioning

confidence: 99%

“…Patients need three days of more than three-hour hemodialysis in a whole week. 4 Coaxial electrospinning can also retain unstable biological external particles and viruses and vindicate the decomposition of unstable compounds. However, the widespread hemodialysis by flux dialyzer is not efficient in removing some notable toxins such as urea and creatinine.…”

Section: Introductionmentioning

confidence: 99%

Producing hybrid nanofiber‐based on /PAN/Fe₃O₄/zeolite/nettle plant extract/urease and a deformed coaxial natural polymer to reduce toxicity materials in the blood of dialysis patients

Bahramimehr

Esmaeili

2019

J Biomedical Materials Res

Self Cite

View full text Add to dashboard Cite

On incidence of kidney failure, the concentration of urea increases and there is need for patients to visit the hospital all through the week for blood purification. However, current hemodialysis has been found to reduce only 66‐75% urea in the blood of patients. The main goal of this article is to observe the effect of biocompatible and high mechanical hemodiafiltration in reducing urea and creatinine within the shortest time frame, using two methods of Nano electrospinning fiber (hybrid and coaxial). Hybrid electrospinning was made by zeolite 940‐HOA(beta), Fe3O4, polyacrylonitrile as well as the addition of nettle plant's leaf extract. Dispersing solution and enzymes were added to two different syringes and was used in making hybrid nanofibers by the electrospinning process. Nessler's Reagent adsorption method was used for measuring the concentration of ammonia after urease enzyme activation. Second coaxial filter was made by the core‐shell electrospinning system and cellulose acetate phthalate (CAP) as well as polyurethane (PU) were utilized. The data show hybrid hemodiafiltration with enzyme coating, decomposed urea and enzymes were activated for two days after electrospinning. The core‐shell filtration can also reduce creatinine. Core‐shell CAP‐PU nanofiber was previously used for intravaginal drug delivery and PU was used as an artificial renal microfluidic chip. Thus, our study focused on using CAP‐PU to reduce creatinine in dialysis patients. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1736–1743, 2019.

show abstract

Nanocellulose‐Based Antibacterial Materials

Cha

Mou

et al. 2018

Adv Healthcare Materials

174

107

View full text Add to dashboard Cite

In recent years, nanocellulose-based antimicrobial materials have attracted a great deal of attention due to their unique and potentially useful features. In this review, several representative types of nanocellulose and modification methods for antimicrobial applications are mainly focused on. Recent literature related with the preparation and applications of nanocellulose-based antimicrobial materials is reviewed. The fabrication of nanocellulose-based antimicrobial materials for wound dressings, drug carriers, and packaging materials is the focus of the research. The most important additives employed in the preparation of nanocellulose-based antimicrobial materials are presented, such as antibiotics, metal, and metal oxide nanoparticles, as well as chitosan. These nanocellulose-based antimicrobial materials can benefit many applications including wound dressings, drug carriers, and packaging materials. Finally, the challenges of industrial production and potentials for development of nanocellulose-based antimicrobial materials are discussed.

show abstract

Electrospinning of thermoplastic carboxymethyl cellulose/poly(ethylene oxide) nanofibers for use in drug-release systems

Cited by 68 publications

References 26 publications

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Producing hybrid nanofiber‐based on /PAN/Fe₃O₄/zeolite/nettle plant extract/urease and a deformed coaxial natural polymer to reduce toxicity materials in the blood of dialysis patients

Nanocellulose‐Based Antibacterial Materials

Contact Info

Product

Resources

About

Electrospinning of thermoplastic carboxymethyl cellulose/poly(ethylene oxide) nanofibers for use in drug-release systems

Cited by 68 publications

References 26 publications

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Encapsulation of rifampin in a polymeric layer‐by‐layer structure for drug delivery

Producing hybrid nanofiber‐based on /PAN/Fe3O4/zeolite/nettle plant extract/urease and a deformed coaxial natural polymer to reduce toxicity materials in the blood of dialysis patients

Nanocellulose‐Based Antibacterial Materials

Contact Info

Product

Resources

About

Producing hybrid nanofiber‐based on /PAN/Fe₃O₄/zeolite/nettle plant extract/urease and a deformed coaxial natural polymer to reduce toxicity materials in the blood of dialysis patients