Electrospinning of polyvinylalcohol–polycaprolactone composite scaffolds for tissue engineering applications

Maheshwari, Subramanian Uma; Kumar, Sourav; Nagiah, Naveen; Uma, T.

doi:10.1007/s00289-013-1002-4

Cited by 35 publications

(20 citation statements)

References 36 publications

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“…Moreover, the aspect of the curves of dynamic viscosity–shear rate dependence is related to topographic reorganization of the films and association phenomena by hydrogen bonding. In this context, these results are in agreement with those of the literature, which reveal that, for biomedical applications, obtaining porous polymer structures is recommended . Thereby, these types of membranes (obtained from PSF/PVA/NMP and CMPSF/PVA/NMP solutions) with superior properties – specific molecular microarchitecture and controlled porosity – can be used to meet the requirements for specific applications.…”

Section: Resultssupporting

confidence: 88%

Rheological and morphological characteristics of multicomponent polysulfone/poly(vinyl alcohol) systems

Filimon¹,

Avram²,

Stoica³

2014

Polymer International

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Section: Resultssupporting

confidence: 88%

Rheological and morphological characteristics of multicomponent polysulfone/poly(vinyl alcohol) systems

Filimon¹,

Avram²,

Stoica³

2014

Polymer International

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“…Nonetheless, the mechanical properties are lower compared to other biopolymers such as PLA (PCL flexural modulus is around 0.48-0.58 GPa, while PLA flexural modulus is around 3.1-3.6 GPa). For this reason, the use of PCL as a tissue engineering scaffold, sometimes, need to study possible modifications by adding fillers or blends [14][15][16][17][18]. Few studies have tested PCL composites as internal fixation systems, such as Lowry et al [13] who prepared fixations of PCL reinforced with glass fiber for rabbit humerus.…”

Section: Introductionmentioning

confidence: 99%

Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite nanotubes

Torres

Fombuena

Vallés-Lluch

et al. 2017

Materials Science and Engineering: C

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Hydroxyapatite (HA) and Halloysite nanotubes (HNTs) percentages have been optimized in Polycaprolactone (PCL) polymeric matrices to improve mechanical, thermal and biological properties of the composites, thus, to be applied in bone tissue engineering or as fixation plates. Addition of HA guarantees a proper compatibility with human bone due to its osteoconductive and osteoinductive properties, facilitating bone regeneration in tissue engineering applications. Addition of HNTs ensures the presence of tubular structures for subsequent drug loading in their lumen, of molecules such as curcumin, acting as controlled drug delivery systems. The addition of 20% of HA and different amounts of HNTs leads to a substantial improvement in mechanical properties with values of flexural strength up to 40% over raw PCL, with an increase in degradation temperature. DMA analyses showed stability in mechanical and thermal properties, having as a result a potential composite to be used as tissue engineering scaffold or resorbable fixation plate.

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“…Using this approach, electrospun fabrics are constructed as artificial prototype grafts to recreate native blood vessels, nerve and smooth muscles, bone and cartilage and endothelial or connective tissues. Literature shows extensively examples of the cited combinations such as blends of PLA with collagen , PCL with collagen , PLA with gelatin , PCL with gelatin , PLA with PHBV , PLA with poly(ethylene glycol) (PEG) , PLA with zein , PCL with zein , PCL with starch , PCL with PVA , and PCL with eggshell membrane protein . Similar studies in the biomedical field have shown that different cell lines were adhered, spread, and grew also on PLGA‐based alloy matrices.…”

Section: Electrospinning Of Polymer Blendsmentioning

confidence: 93%

“…However, other biodegradable polymers and polymer blends have been additionally proposed, as they also offer the advantage of being resorbable and more physically stable. This for example includes PLA , PCL , PLA and PCL blends , PCL and PVA blends , PLA and collagen blends , PCL and collagen blends , PCL and gelatin blends , PCL and chitosan blends , silk fibroin , PHB , PHBV , PVA , poly(ester amide) (PEA) , poly(butylene succinate) (PBS) , etc. The presence of nHA in these electrospun scaffolds successfully showed high osteogenic capabilities of a variety of cell types and supported the growth of clinically relevant bone tissues.…”

Section: Electrospun Nanobiocomposite Fibersmentioning

confidence: 99%

A review on electrospun polymer nanostructures as advanced bioactive platforms

2016

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This review article deals with latest literature studies on the potential use of polymer ultrathin and nanosized structures obtained by electrospinning to design novel engineered materials with bioactive properties. The electrofluidodynamic process offers the option to form high-performance bioactive systems based on polymer yarns of nanofibers or coatings of nanobeads with high surface-to-volume ratios. The electrospun and electrosprayed nanostructures can be further functionalized by encapsulation with bioactive fillers and substances. For both scenarios, the resultant polymer nanostructures present unique bioactive properties capable of providing a beneficial impact over human's health and with improved and advanced performance for biomedicine, pharmaceutics, nutrition, bioengineering, and healthcare applications. These novel functional materials attained by the electrospinning technology can be of interest for many bioactive applications such as functional food design, food packaging, functional coatings, controlled delivery of drug solutions and, mainly, tissue engineering. This article is purposely designed to gather, for the first time, most recent and promising multi-and inter-disciplinary develop-

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Electrospinning of polyvinylalcohol–polycaprolactone composite scaffolds for tissue engineering applications

Cited by 35 publications

References 36 publications

Rheological and morphological characteristics of multicomponent polysulfone/poly(vinyl alcohol) systems

Rheological and morphological characteristics of multicomponent polysulfone/poly(vinyl alcohol) systems

Improvement of mechanical and biological properties of Polycaprolactone loaded with Hydroxyapatite and Halloysite nanotubes

A review on electrospun polymer nanostructures as advanced bioactive platforms

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