Electrospinning of Poly(lactic acid) Stereocomplex Nanofibers

Tsuji, Hideto; Nakano, Michihiko; Hashimoto, Makoto; Takashima, Kazunori; Katsura, Shinji; Mizuno, Akira

doi:10.1021/bm060786e

Cited by 176 publications

(160 citation statements)

References 49 publications

(126 reference statements)

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“…4B) induces a decrease of the glass transition temperature from 61 to 57 C. A previous study by Zong et al attributed this behavior to an increase of the surface to volume ratio in electrospun materials having air as a plasticizer. Obviously T c max À T g mid also decreases from 43 C to 30 C. This observation is usual in electrospun fibers [31,32,43] as the orientation of the macromolecules enhances the coldcrystallization which therefore occurs at a lower temperature. In the case of electrospun fibers, Tsuji et al [43] conclude that the crystallization has been frozen by the fast removal of the solvent from the electrospun fibers.…”

Section: Tablementioning

confidence: 84%

“…Obviously T c max À T g mid also decreases from 43 C to 30 C. This observation is usual in electrospun fibers [31,32,43] as the orientation of the macromolecules enhances the coldcrystallization which therefore occurs at a lower temperature. In the case of electrospun fibers, Tsuji et al [43] conclude that the crystallization has been frozen by the fast removal of the solvent from the electrospun fibers. Edwards et al [44] and Ma et al [32] even consider that extended polymer chains in electrospun fibers can act as row nuclei during heating just above glass transition.…”

Section: Tablementioning

confidence: 84%

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Molecular dynamics in electrospun amorphous plasticized polylactide fibers

Monnier

Delpouve

Basson

et al. 2015

Polymer

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is an open access repository that collects the work of Arts et Métiers ParisTech researchers and makes it freely available over the web where possible. The molecular dynamics in the amorphous phase of electrospun fibers of polylactide (PLA) has been investigated using the cooperative rearranging region concept. An unusual and significant increase of the cooperativity length at the glass transition induced by the electrospinning has been observed. This behavior is attributed to the singularity of the amorphous phase organization. Electrospun PLA fibers rearrange in a pre-ordered metastable state which is characterized by highly oriented but non-crystalline polymer chains, and the presence of highly cohesive mesophase which plays the role of an anchoring point in the amorphous phase. The successful processing of electrospun fibers of plasticized polylactide is also demonstrated. It is shown that the plasticizer remains in the polymer matrix of the nanofiber after electrospinning. When PLA is plasticized, the loosening of the macromolecules prevails over the preferential orientation of the chains; therefore no mesophase is formed during the electrospinning and the cooperativity length remains the same. When the content of plasticizer increases, the inter-chain characteristic distances estimated from wide angle X-ray scattering (WAXS) are redistributed, suggesting a change in the level of interactions between macromolecules. It is assumed that the resulting decrease of the cooperativity length is driven by the progressive reduction of the number of inter-chain weak bonds. It is shown that in a non-confined environment, the number of structural entities involved in the alpha relaxation is strongly dependent on the level of physical interactions in the amorphous phase.

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Section: Tablementioning

confidence: 84%

Section: Tablementioning

confidence: 84%

Molecular dynamics in electrospun amorphous plasticized polylactide fibers

Monnier

Delpouve

Basson

et al. 2015

Polymer

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“…The peak area of SC increased and that of HC decreased with the decreasing fiber diameter. Tsuji et al 10 reported that the orientation caused by the high voltage or the electrically induced high extensional force during electrospinning process enhances the formation and growth of SC suppressing the formation of HC. In our study, an additional extensional force was given to the spinline by the rotating target.…”

Section: Thermal Analysesmentioning

confidence: 99%

Effect of the Take-Up Velocity on the Higher-Order Structure of the Melt-Electrospun PLLA/PDLA Blend Fibers

et al. 2015

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The higher-order structure and the formations of SC and HC of the PLLA/PDLA blend melt-electrospun fibers collected on a rotating target were investigated. The diameter of the fiber decreased and the orientation factor increased with increasing take-up velocity. The formation of SC was promoted with decreasing fiber diameter and with increasing take-up velocity. The fiber collected on the fixed target was amorphous and did not show the molecular orientation to any particular directions indicating that the stretching of the fiber by the electrostatic force did not give much molecular orientation to the fiber. On the other hand, the stretching of the fiber by applying the mechanical taking-up gave a significant degree of the molecular orientation to the fiber direction. The crystalline orientation of HC of the annealed fiber was higher than that of SC.

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“…To obtain a final product that is flexible, porous, and able to support cell proliferation, electrospinning is often used to produce PLLA nanofibers. 6,7,11 In this process, a polymer solution is ejected under a high-tension electrical field to enable the formation of mesh with a fiber diameter below the micrometer range. Although this technique is very well adapted to research applications, it is unfortunately timeconsuming and scarcely transferable to industrial applications.…”

Section: Introductionmentioning

confidence: 99%

Characterization of an air‐spun poly(L‐lactic acid) nanofiber mesh

et al. 2010

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It was previously showed that PLLA nanofiber mesh promoted good endothelial cell proliferation. A new technique was developed to produce nanofibers by air jet spinning inside the tubular shape of vascular prostheses and to characterize this nanofiber mesh. Polymer macromolecule stability was assessed by gel permeation chromatography. Thermal analyses were conducted with differential scanning calorimetry and dynamic mechanical analysis on PLLA nanofibers obtained with 4% and 7% solutions (w/v) in chloroform. Polyethylene terephthalate (PET) was also treated with atmospheric pressure dielectric barrier discharge under air or nitrogen atmosphere to optimize PLLA nanofiber adherence, assessed by peel tests. Air spinning induced a reduction of number-average molecular weight (M(n)) for the 7% PLLA solution but not for the 4% solution. The nanofibers were more crystalline and less sensible to viscoelastic relaxation as a function of aging in the 4% solution than in the 7% solution. Discharge treatment of the PET promoted identical surface modification on PET film and PET textile surfaces. Moreover, the best PLLA nanofibers adhesion results were obtained under nitrogen atmosphere. This study demonstrates that it is possible to coat the internal side of tubular vascular prostheses with PLLA nanofibers, and provides a better understanding of the air spinning process as well as optimizing nanofibers adhesion.

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Electrospinning of Poly(lactic acid) Stereocomplex Nanofibers

Cited by 176 publications

References 49 publications

Molecular dynamics in electrospun amorphous plasticized polylactide fibers

Molecular dynamics in electrospun amorphous plasticized polylactide fibers

Effect of the Take-Up Velocity on the Higher-Order Structure of the Melt-Electrospun PLLA/PDLA Blend Fibers

Characterization of an air‐spun poly(L‐lactic acid) nanofiber mesh

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