Electrospinning of Highly Porous Scaffolds for Cartilage Regeneration

Thorvaldsson, Anna; Stenhamre, Hanna; Gatenholm, Paul; Walkenström, Pernilla

doi:10.1021/bm701225a

Cited by 197 publications

(139 citation statements)

References 31 publications

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“…In collector 3, the installed Teflon sheet on gap region also appeared to be unable to provide support. Teflon might resist fibre attachment and provide repulsion effect [29]. In contrast with collector 4, fibres from collector 1 might not undergo drawing and tension, thus providing a more elastic property.…”

Section: Tensile Propertiesmentioning

confidence: 99%

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

Anindyajati

Boughton

Ruys

2015

MATEC Web of Conferences

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Abstract. Electrospinning is a technique that can produce fibres in the nanoscale range. This process is useful for many applications, including fabrication of fibrous scaffolds for fibrocartilage tissue engineering. For this application, cell attachment and tissue development is influenced by fibre morphology and mechanical properties. This electrospinning study investigated the influence of rotating collector design on morphology and mechanical properties of electrospun polycaprolactone fibre. The experiment employed 4 mandrel designs: 1) full surface of aluminium; 2) with gap feature; 3) with gap feature and teflon support; 4) with gap feature and tape support. The highest elastic modulus was obtained from mandrel with gap and tape support, which was 24.6 MPa and significantly higher compared to fibres acquired from other collector designs. Fibre diameter attained was identical across the different collectors, ranging from 0.5 -2 µm. Gap introduction showed enhanced alignment in the resultant fibre. It can be concluded that fibre alignment and tensile properties can be improved by simply modifying the collector design. This improved fibre mat can be developed as a biomaterial for fibrocartilage tissue engineering scaffolds.

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Section: Tensile Propertiesmentioning

confidence: 99%

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

Anindyajati

Boughton

Ruys

2015

MATEC Web of Conferences

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“…The latter approach generates micron-sized inter-fiber spaces because pore size, in general, scales with fiber diameter. As a possible compromise to maintain the nanometer-diameter fibers and high surface area and micrometer-diameter fibers for sufficient pore-size for air/fluid diffusion, some researchers have explored forming composites of nanometer and micrometer fibers [57,58], electrospinning nanometer fibers onto micrometer fibers [59], and electrospinning nanometer fibers of two polymers, and then later removing the fibers from one of the polymers to increase the porosity [60].…”

Section: Porositymentioning

confidence: 99%

Hierarchically Structured Electrospun Fibers

Zander

2013

Polymers

125

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Abstract:Traditional electrospun nanofibers have a myriad of applications ranging from scaffolds for tissue engineering to components of biosensors and energy harvesting devices. The generally smooth one-dimensional structure of the fibers has stood as a limitation to several interesting novel applications. Control of fiber diameter, porosity and collector geometry will be briefly discussed, as will more traditional methods for controlling fiber morphology and fiber mat architecture. The remainder of the review will focus on new techniques to prepare hierarchically structured fibers. Fibers with hierarchical primary structures-including helical, buckled, and beads-on-a-string fibers, as well as fibers with secondary structures, such as nanopores, nanopillars, nanorods, and internally structured fibers and their applications-will be discussed. These new materials with helical/buckled morphology are expected to possess unique optical and mechanical properties with possible applications for negative refractive index materials, highly stretchable/high-tensile-strength materials, and components in microelectromechanical devices. Core-shell type fibers enable a much wider variety of materials to be electrospun and are expected to be widely applied in the sensing, drug delivery/controlled release fields, and in the encapsulation of live cells for biological applications. Materials with a hierarchical secondary structure are expected to provide new superhydrophobic and self-cleaning materials.

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“…Because biodegradability is an essential material requirement in tissue engineering, numerous potentially biodegradable polymers including poly(α-hydroxy acids) and their copolymers [11], polyanhydrides [12], collagen [13], gelatin [14], chitosan [15], or silk [16] have been used to fabricate scaffolds for cell culture. Numerous studies have shown that different types of cells including osteoblasts [17], chondrocytes [18], fibroblasts [19], keratinocytes [20], or cardiomyocytes [21] are able to adhere and proliferate well when cultured on those electrospun scaffold materials.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

et al. 2014

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Non-woven hybrid meshes based on poly(llactide-co-d,l-lactide) (dl-PLA) and β-tricalcium phosphate (β-TCP) were fabricated and comprehensively characterized. Stock suspensions of β-TCP powder in dl-PLA acetone solutions were used for the electrospinning process. Structure, morphology and thermal properties of the electrospun samples were investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The electrospun hybrid materials show a micro-composite structure, and a morphology characterized by a three-dimensional porous fibrous mesh with randomly distributed fibers possessing average fiber diameters between 680 and 970 nm, uniform thickness along the fibers and beads structure only for higher β-TCP concentration electrospun samples. Both pure PLA and hybrid non-woven meshes exhibit a good thermal stability and a continuous degradation in simulated body fluid medium. A live/dead staining viability assay using MC3T3-E1 preosteoblasts reveals the excellent cytocompatibility of the fabricated non-wovens. Enhanced alkaline phosphatase (AP) activity of MC3T3-E1 cells during culture on the dl-PLA and the composite non-woven meshes demonstrates their potential for applications in hard tissue repair.

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Electrospinning of Highly Porous Scaffolds for Cartilage Regeneration

Cited by 197 publications

References 31 publications

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

The Effect of Rotating Collector Design on Tensile Properties and Morphology of Electrospun Polycaprolactone Fibres

Hierarchically Structured Electrospun Fibers

Fabrication and characterization of electrospun polylactide/β-tricalcium phosphate hybrid meshes for potential applications in hard tissue repair

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