Electrospinning of double-layer chitosan-flaxseed mucilage nanofibers for sustained release of Ziziphora clinopodioides essential oil and sesame oil

Karami, Negin; Kamkar, Abolfazl; Shahbazi, Yasser; Misaghi, Ali

doi:10.1016/j.lwt.2020.110812

Cited by 60 publications

(23 citation statements)

References 47 publications

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“…Almost 30%–40% reduction in viscosity was noticed for dopes with BAs. This outcome is in line with a previous study where EO addition resulted in lowering of dope viscosity (Karami et al., 2021). However, increasing the concentration of BAs from 1% to 5% did not increase dope viscosity significantly.…”

Section: Resultssupporting

confidence: 93%

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Functionalization of electrospun fish gelatin mats with bioactive agents: Comparative effect on morphology, thermo‐mechanical, antioxidant, antimicrobial properties, and bread shelf stability

Mahmood

Kamilah

Alias

et al. 2021

Food Science & Nutrition

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In the current study, fish gelatin‐based nanofiber mats were embedded with different bioactive agents (BAs) such as cinnamaldehyde (CEO), limonene (LEO), and eugenol (EEO) at 1, 3, and 5% via electrospinning, and their effects on the morphological, structural, mechanical, thermal, antioxidant, antimicrobial, and bread packaging properties of the mats were evaluated. The gelatin mats presented different physicochemical properties due to the inherent differences in the chemical structure of the added BAs and their interaction with the gelatin chains. The conductivity, surface tension, and viscosity of gelatin dopes changed with the presence of the BAs, yet the electrospun nanofibers showed defect‐free uniform morphology as confirmed by electron microscopy, with no significant change in the chemical structure of gelatin. The melting temperature of gelatin mats remained in the range of 187–197°C. The mats presented lower tensile strength and elongation at break by the addition of BAs compared with the pristine gelatin mat. The highest radical scavenging (90%) was yielded by mats with EEO, while mats with CEO depicted better antibacterial activity with an inhibition zone of 18.83 mm. However, a dose‐dependent increase in the antifungal properties was noticed for all the mats. The mats retained almost 50% of BAs after 60 days of storage at 45% relative humidity. Electrospun gelatin mats inhibited the aerobic bacteria (81%) and yeast and molds (61%) in preservative‐free bread after 10 days of storage.

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Section: Resultssupporting

confidence: 93%

“…Karami et al. (2021) also reported reduced conductivity of dope prepared from chitosan‐flaxseed mucilage added with Ziziphora clinopodioides EO.…”

Section: Resultsmentioning

confidence: 98%

Functionalization of electrospun fish gelatin mats with bioactive agents: Comparative effect on morphology, thermo‐mechanical, antioxidant, antimicrobial properties, and bread shelf stability

Mahmood

Kamilah

Alias

et al. 2021

Food Science & Nutrition

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“…Chitosan–FM nanofibers enriched with the essential oil of Ziziphora clinopodioides (ZEO) and sesame oil (SO) were prepared using an electrospinning approach [ 69 ]. These fibers exhibited good antimicrobial and antioxidant properties; they can potentially be used in food packaging applications for ZEO and SO encapsulation and for their sustained release.…”

Section: Food Applications Of Fm/fgmentioning

confidence: 99%

A Review of Extraction Techniques and Food Applications of Flaxseed Mucilage

Puligundla

Lim

2022

Foods

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Flaxseed contains significant concentration of mucilage or gum (a type of hydrocolloid). Flaxseed mucilage (FM) predominantly occurs in the outermost layer of the seed’s hull and is known to possess numerous health benefits such as delayed gastric emptying, reduced serum cholesterol, and improved glycemic control. FM is typically composed of an arabinoxylan (neutral in nature) and a pectic-like material (acidic in nature). Similar to gum arabic, FM exhibits good water-binding capacity and rheological properties (similar functionality); therefore, FM can be used as its replacement in foods. In this review, an overview of methods used for FM extraction and factors influencing the extraction yield were discussed initially. Thereafter, food applications of FM as gelling agent/gel-strengthening agent, structure-forming agent, stabilizing agent, fat replacer, anti-retrogradation agent, prebiotic, encapsulating agent, edible coatings and films/food packaging material, and emulsifier/emulsion stabilizer were included. At the end, some limitations to its wide application and potential solutions were added.

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“…Sustained release, one of the most popular and common release profiles, refers to the slow release of the loaded drugs from its dosage forms in the specified release medium after oral administration [1][2][3][4][5]. Compared with the fast release dosage forms, the administration frequency can be reduced, and, thus, the sustained release profile can significantly increase the patient's compliance [6][7][8][9]. Meanwhile, the sustained release of the drug can also effectively keep the drug blood concentration from being a toxic value, and correspondingly reduce the possible side effects of the drug [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

et al. 2021

Biomolecules

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The sustained release of a water-soluble drug is always a key and important issue in pharmaceutics. In this study, using cellulose acetate (CA) as a biomacromolecular matrix, core-sheath nanofibers were developed for providing a sustained release of a model drug—metformin hydrochloride (MET). The core–sheath nanofibers were fabricated using modified tri-axial electrospinning, in which a detachable homemade spinneret was explored. A process—nanostructure–performance relationship was demonstrated through a series of characterizations. The prepared nanofibers F2 could release 95% of the loaded MET through a time period of 23.4 h and had no initial burst effect. The successful sustained release performances of MET can be attributed to the following factors: (1) the reasonable application of insoluble CA as the filament-forming carrier, which determined that the drug was released through a diffusion manner; (2) the core–sheath nanostructure provided the possibility of both encapsulating the drug completely and realizing the heterogeneous distributions of MET in the nanofibers with a higher drug load core than the sheath; (3) the thickness of the sheath sections were able to be exploited for further manipulating a better drug extended release performance. The mechanisms for manipulating the drug sustained release behaviors are proposed. The present proof-of-concept protocols can pave a new way to develop many novel biomolecule-based nanostructures for extending the release of water-soluble drugs.

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Electrospinning of double-layer chitosan-flaxseed mucilage nanofibers for sustained release of Ziziphora clinopodioides essential oil and sesame oil

Cited by 60 publications

References 47 publications

Functionalization of electrospun fish gelatin mats with bioactive agents: Comparative effect on morphology, thermo‐mechanical, antioxidant, antimicrobial properties, and bread shelf stability

Functionalization of electrospun fish gelatin mats with bioactive agents: Comparative effect on morphology, thermo‐mechanical, antioxidant, antimicrobial properties, and bread shelf stability

A Review of Extraction Techniques and Food Applications of Flaxseed Mucilage

The Effect of Drug Heterogeneous Distributions within Core-Sheath Nanostructures on Its Sustained Release Profiles

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