Electrospinning of carboxymethyl chitin/poly(vinyl alcohol) nanofibrous scaffolds for tissue engineering applications

Shalumon, K.T.; Sathy, Binulal N.; Selvamurugan, N.; Nair, Shantikumar V.; Menon, Deepthy; Furuike, Tetsuya; Tamura, Hiroshi; Jayakumar, R.

doi:10.1016/j.carbpol.2009.03.009

Cited by 249 publications

(110 citation statements)

References 33 publications

(32 reference statements)

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“…Carbomethyl chitin (CMC) is one of the chitin derivatives that are readily soluble in water. However, the electrospinning of CMC from its aqueous solution results in spherical drops [177]. Nevertheless, ultrafine nanofibres from a CMC/PVA blend at a 20:80 ratio (CMC (7%):PVA (8%)) was reported.…”

Section: Carboxymethyl Chitinmentioning

confidence: 99%

A review on electrospun bio-based polymers for water treatment

Mokhena¹,

Jacobs²,

Luyt³

2015

Express Polym. Lett.

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Abstract. Over the past decades, electrospinning of biopolymers down to nanoscale garnered much interest to address most of the millennia issues related to water treatment. The fabrication of these nanostructured membranes added a new dimension to the current nanotechnologies where a wide range of materials can be processed to their nanosize. Electrospinning is a simple and versatile technique to fabricate unique nanostructured membranes with fascinating properties for a wide spectrum of applications such as filtration and others. These nanostructured membranes, fabricated by electrospinning, were found to be of a paramount importance because of their advanced inherited properties such as large surface-to-volume ratio, as well as tuneable porosity, stability, and high permeability. The extensive research conducted on these materials extended the success of electrospinning not only to bio-based polymer nanofibres, but to their hybrids and their derivatives. The technique also created avenues for advanced and massive production of nanofibres. This paper reviews the recent developments in the electrospinning technique. Electrospinning of biopolymers, their blends and functionalization using metals/metal oxides, and the potential applications of electrospun nanofibrous membranes in water filtration are discussed.

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Section: Carboxymethyl Chitinmentioning

confidence: 99%

A review on electrospun bio-based polymers for water treatment

Mokhena¹,

Jacobs²,

Luyt³

2015

Express Polym. Lett.

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“…Therefore, this scaffold was suggested for wound tissue engineering applications. Shalumon et al, 2009 developed CMC/PVA blend nanofibrous scaffold for tissue engineering applications. The prepared nanofibers were bioactive and biocompatible.…”

Section: Applications Of Chitin and Chitosan Nano-fibers In Tissue-enmentioning

confidence: 99%

“…The average diameters of chitin/SF blend fibers decreased from 920 to 340 nm, with the increase of chitin content in blend compositions. Shalumon et al, 2009 developed a novel electrospun water-soluble carboxymethyl chitin (CMC)/PVA blend was successfully prepared by electrospinning technique. The concentration of CMC (7%) with PVA (8%) was optimized, blended in different ratios (0-100%) and electrospun to get nanofibers.…”

Section: Introductionmentioning

confidence: 99%

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Jayakumar¹,

Nair²,

Furuike³

et al. 2010

Tissue Engineering

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Chitin and its deacetylated derivative, chitosan, are non-toxic, biodegradable biopolymers currently being developed for use in biomedical applications such as tissue engineering scaffolds, wound dressings, separation membranes, antibacterial coatings, stent coatings, and sensors. Recently, nano fibrous scaffolds based on chitin or chitosan have potential applications in tissue engineering. Tissue engineering is one of the most exciting interdisciplinary and multidisciplinary research areas today, and there has been exponential growth in the number of research publications in this area in recent years. It involves the use of living cells, manipulated through their extracellular environment or genetically to develop biological substitutes for implantation into the body and/or to foster remodeling of tissues in some active manners. Electrospun chitin and chitosan nano fibrous scaffolds would be used to produce tissue engineering scaffolds with improved cytocompatibility, which could mimic the native extracellular matrix (ECM). Electrospinning is truly a feasible means of producing nano fibrous scaffolds that resemble the ECM, however, moreover than this, it is imperative that the effects of an artificial matrix has on cell growth, proliferation, and differentiation. This review summarizes the recent progress in chitin and chitosan based nano fibrous scaffolds with an emphasis in tissue engineering applications.

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“…Membranes based on nanofibers that have generally varying diameters from several nm to greater than 5 m (Quynh, Sharma, & Mikos, 2006) can be used as drug holders, as filtration membranes, catalytic nanofibers, fiber-based sensors, and tissue engineering scaffolds (Shalumon et al, 2009). There is a wide range of spinnable polymers; however, only few of them have the required properties to make them suitable for use in such critical applications.…”

Section: Introductionmentioning

confidence: 99%

Effect of nonionic surfactant and acidity on chitosan nanofibers with different molecular weights

Ziani

Henrist

Jérôme

et al. 2011

Carbohydrate Polymers

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a b s t r a c tBlend solutions of chitosan (Cs) and poly(ethylene oxide) (PEO) at different acidities were electrospun to produce membranes of nanofibers with different diameters. The use of polysorbate surfactant Tween 20 to improve functionality of these nanofibers was studied. The procedure was as follows: 5% (w/v) of two high deacetylation degree Cs with different molecular weights (Mw = 148 kDa and 68 kDa) were dissolved in solutions with different acetic acid concentrations (10%, 50% and 90% (v/v)) then mixed with PEO. The influence of molecular weight and acidity on the morphology and physicochemical properties of solutions and formed nanofibers was also investigated. Results revealed that pure Cs dissolved in different acidities did not form fibers and instead it deposited as beads. Addition of PEO was necessary to electrospin all Cs solutions. Average fiber diameters and size distribution differ with acidity and molecular weight. Composite solutions of Cs, synthetic polymer PEO, and surfactant can be effectively electrospun. The presence of surfactant resulted in decrease of surface tension and in the formation of smooth or beaded fibers. This may be important for new applications since active nanofibers could serve as carriers of components such as drugs or additives.

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Electrospinning of carboxymethyl chitin/poly(vinyl alcohol) nanofibrous scaffolds for tissue engineering applications

Cited by 249 publications

References 33 publications

A review on electrospun bio-based polymers for water treatment

A review on electrospun bio-based polymers for water treatment

Perspectives of Chitin and Chitosan Nanofibrous Scaffolds in Tissue Engineering

Effect of nonionic surfactant and acidity on chitosan nanofibers with different molecular weights

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