Electrospinning of carboxyethyl chitosan/poly(vinyl alcohol)/silk fibroin nanoparticles for wound dressings

Zhou, Yingshan; Yang, Hongjun; Liu, Xin; Mao, Jun; Gu, Shaojin; Xu, Weilin

doi:10.1016/j.ijbiomac.2012.11.013

Cited by 163 publications

(81 citation statements)

References 31 publications

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“…[35][36][37] Earlier workers have reported various biocompatible wound dressings; 5,6,[10][11][12] however, we herein report the synergistic effect of CuO and virgin olive oil for enhanced wound-healing application. The advantage of this proposed dressing is that it is based on a mixture of organic and inorganic components, supplemented by natural material.…”

mentioning

confidence: 62%

“…10 For instance, carboxyethyl chitosan/ poly(vinyl alcohol)/silk fibroin-based wound dressings have been proposed for skin regeneration. 11 In another report, sodium alginate/poly(vinyl alcohol)/nano zinc oxide composite nanofibers for antibacterial wound dressings have been designed. 12 Nevertheless, to our knowledge, there is no report on the fabrication of copper oxide (CuO) and virgin olive oil-based wound dressings.…”

Section: Amna Et Almentioning

confidence: 99%

See 1 more Smart Citation

Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

Amna¹,

Hassan²,

Yang³

et al. 2014

IJN

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Recently, substantial interest has been generated in using electrospun biomimetic nanofibers of hybrids, particularly organic/inorganic, to engineer different tissues. The present work, for the first time, introduced a unique natural and synthetic hybrid micronanofiber wound dressing, composed of virgin olive oil/copper oxide nanocrystals and polyurethane (PU), developed via facile electrospinning. The as-spun organic/inorganic hybrid micronanofibers were characterized by scanning electron microscopy (SEM), energy dispersive X-ray analysis, X-ray diffraction, electron probe microanalysis, and transmission electron microscopy. The interaction of cells with scaffold was studied by culturing NIH 3T3 fibroblasts on an as-spun hybrid micronanofibrous mat, and viability, proliferation, and growth were assessed. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay results and SEM observation showed that the hybrid micronanofibrous scaffold was noncytotoxic to fibroblast cell culture and was found to benefit cell attachment and proliferation. Hence our results suggest the potential utilization of as-spun micronanoscaffolds for tissue engineering. Copper oxide–olive oil/PU wound dressing may exert its positive beneficial effects at every stage during wound-healing progression, and these micronanofibers may serve diverse biomedical applications, such as tissue regeneration, damaged skin treatment, wound healing applications, etc. Conclusively, the fabricated olive oil–copper oxide/PU micronanofibers combine the benefits of virgin olive oil and copper oxide, and therefore hold great promise for biomedical applications in the near future.

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mentioning

confidence: 62%

Section: Amna Et Almentioning

confidence: 99%

Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

Amna¹,

Hassan²,

Yang³

et al. 2014

IJN

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“…An infection of a wound is initiated by the adherences of bacteria to the surface of wounds, antibiotics, antimicrobial agents, and metallic particles are incorporated with the dressings. Therefore, antibacterial agents, such as chitosan [37], silver nanoparticles [38], or zinc oxide (ZnO) [39], have been added to electrospun nanofibers, thus increasing their potential in biomedical engineering applications.…”

Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Antibacterial Nanofiber Mats Made of Electrospinning with Wire Electrodes

2016

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Twisted stainless steel wires are used as wire electrodes for electrospinning the polyvinyl alcohol (PVA)/zinc citrate nanofiber mats. The morphology and diameter of the nanofibers in PVA/zinc citrate nanofiber mats are evaluated. We measured the antibacterial efficacy against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) of the nanofiber mats. We also examined the cell adhesion affinity of mammalian tissue culture cells on these nanofiber mats. Our results indicate that an increase in zinc citrate increases the viscosity and electrical conductivity of PVA solution. In addition, increasing zinc citrate results in a smaller diameter of nanofibers that reaches below 100 nm. According to the antibacterial test results, increasing zinc citrate enlarges the inhibition zone of S. aureus but only has a bacteriostatic effect against E. coli. Finally, cell adhesion test results indicate that all nanofiber mats have satisfactory cell attachment regardless of the content of zinc citrate.

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“…And it indicated that strong interaction occurred among TOCN, PVA, and WPU molecules in the composite nanofibers. 36 Crystallinity indexes were determined from the XRD data. And as expected, the incorporation of TOCNs produced an increase of 2% in the crystallinity index of composite nanofibers.…”

Section: Xrd Datamentioning

confidence: 99%

Electrospun polyvinyl alcohol/waterborne polyurethane composite nanofibers involving cellulose nanofibers

Dai

Long

Ren

et al. 2014

J of Applied Polymer Sci

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TEMPO-oxidized cellulose nanofibers (TOCNs) were used as nanofillers in this work. Composite nanofibers of polyvinyl alcohol (PVA)/waterborne polyurethane (WPU) reinforced with TOCNs were produced by electrospinning. The reinforcing capability of TOCNs was investigated by tensile tests. Scanning electron microscopy (SEM), X-ray diffraction, and thermogravimetry analyses were also carried out in order to characterize the appearance, crystallinity, and reinforcing effect of the cellulose nanofibers. SEM results showed that PVA/WPU/TOCNs composite nanofibers presented a highly homogeneous dispersion of TOCNs. The reinforced composites had about 44% increase in their mechanical properties with addition of only 5 wt % of TOCNs while about 42% decrease in elongation at break. The TOCNs reinforced composite nanofibers were more thermally stable than pure PVA/WPU nanofibers. The development of crystalline structure in the composite fibers was observed by XRD. Since PVA, WPU, and TOCNs are hydrophilic, non-toxic, and biocompatible, and therefore, these nanocomposite nanofibers could be used for tissue scaffolding, filtration materials, and medical industries as wound dressing materials.

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Electrospinning of carboxyethyl chitosan/poly(vinyl alcohol)/silk fibroin nanoparticles for wound dressings

Cited by 163 publications

References 31 publications

Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

Virgin olive oil blended polyurethane micro/nanofibers ornamented with copper oxide nanocrystals for biomedical applications

Biomedical Applications of Antibacterial Nanofiber Mats Made of Electrospinning with Wire Electrodes

Electrospun polyvinyl alcohol/waterborne polyurethane composite nanofibers involving cellulose nanofibers

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