Electrospinning for drug delivery applications: A review

Luraghi, Andrea; Peri, Francesco; Moroni, Lorenzo

doi:10.1016/j.jconrel.2021.03.033

Cited by 374 publications

(202 citation statements)

References 146 publications

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“…In this study, we present different strategies to develop microfabricated scaffolds with increased biofunctionality via using the delivery of angiogenic agents 2dDr, E2, or AV. The inclusion of biofunctional agents within the electrospinning process required careful optimization of the parameters and in some cases, the desired microstructure cannot be achieved without significantly changing the polymer solution properties [ 16 , 46 , 47 ]. To fabricate the TCES it is critical to control the directionality of the electrospinning jet to force the electrospun fibers to populate the microfeatures of the collector.…”

Section: Discussionmentioning

confidence: 99%

“…A powerful approach for the introduction of biological agents within scaffolds for skin tissue regeneration is the use of electrospinning [ 5 , 12 , 13 , 14 ]. Electrospinning is a versatile advanced manufacturing technique that allows the creation of high-surface fibrous membranes that can also be used as drug delivery carriers [ 15 , 16 , 17 ]. The combination of manufacturing techniques such as microstereolithography and electrospinning has also been explored to increase construct complexity by creating micropatterned fibrous membranes [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Delivery of Bioactive Compounds to Improve Skin Cell Responses on Microfabricated Electrospun Microenvironments

et al. 2021

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The introduction of microtopographies within biomaterial devices is a promising approach that allows one to replicate to a degree the complex native environment in which human cells reside. Previously, our group showed that by combining electrospun fibers and additive manufacturing it is possible to replicate to an extent the stem cell microenvironment (rete ridges) located between the epidermal and dermal layers. Our group has also explored the use of novel proangiogenic compounds to improve the vascularization of skin constructs. Here, we combine our previous approaches to fabricate innovative polycaprolactone fibrous microtopographical scaffolds loaded with bioactive compounds (2-deoxy-D-ribose, 17β-estradiol, and aloe vera). Metabolic activity assay showed that microstructured scaffolds can be used to deliver bioactive agents and that the chemical relation between the working compound and the electrospinning solution is critical to replicate as much as possible the targeted morphologies. We also reported that human skin cell lines have a dose-dependent response to the bioactive compounds and that their inclusion has the potential to improve cell activity, induce blood vessel formation and alter the expression of relevant epithelial markers (collagen IV and integrin β1). In summary, we have developed fibrous matrixes containing synthetic rete-ridge-like structures that can deliver key bioactive compounds that can enhance skin regeneration and ultimately aid in the development of a complex wound healing device.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Delivery of Bioactive Compounds to Improve Skin Cell Responses on Microfabricated Electrospun Microenvironments

et al. 2021

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“…The factors affecting the electrospinning process can be divided into (i) processing, (ii) solution and solvent, and (iii) environment parameters (Table 1) [15,[33][34][35]. Important processing parameters include the flow rate, applied voltage, and the distance between the collector and the spinneret.…”

Section: Principles Of Electrospinningmentioning

confidence: 99%

“…Polymers in particular offer the opportunity to tune the release rate over a wide range. Synthethic and natural polymers are both widely available, and many are biodegradable and biocompatible [15].…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

et al. 2021

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Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.

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“…The electrospun fibers show fitness Molecules 2021, 26, 4866 2 of 17 in diversified technological fields such as filtration, protective clothing, wound healing, and other biomedical applications [10][11][12][13]. In particular, the use of electrospun fibers is highly promising for scaffolds in tissue engineering and drug delivery [13][14][15][16][17]. High surface area, high drug loading capacity, porosity, simultaneous delivery of different therapeutic agents, adequate mechanical strength, and cost-effectiveness are appealing characteristics for use in drug delivery systems [18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and Antibiofilm Activity of Curcumin-Loaded Electrospun Nanofibers for the Prevention of the Biofilm-Associated Infections

Salle¹,

Viscusi

Cristo³

et al. 2021

Molecules

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Curcumin extracted from the rhizome of Curcuma Longa has been used in therapeutic preparations for centuries in different parts of the world. However, its bioactivity is limited by chemical instability, water insolubility, low bioavailability, and extensive metabolism. In this study, the coaxial electrospinning technique was used to produce both poly (ε-caprolactone) (PCL)–curcumin and core–shell nanofibers composed of PCL and curcumin in the core and poly (lactic acid) (PLA) in the shell. Morphology and physical properties, as well as the release of curcumin were studied and compared with neat PCL, showing the formation of randomly oriented, defect-free cylindrical fibers with a narrow distribution of the dimensions. The antibacterial and antibiofilm potential, including the capacity to interfere with the quorum-sensing mechanism, was evaluated on Pseudomonas aeruginosa PAO1, and Streptococcus mutans, two opportunistic pathogenic bacteria frequently associated with infections. The reported results demonstrated the ability of the Curcumin-loading membranes to inhibit both PAO1 and S. mutans biofilm growth and activity, thus representing a promising solution for the prevention of biofilm-associated infections. Moreover, the high biocompatibility and the ability to control the oxidative stress of damaged tissue, make the synthesized membranes useful as scaffolds in tissue engineering regeneration, helping to accelerate the healing process.

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Electrospinning for drug delivery applications: A review

Cited by 374 publications

References 146 publications

Delivery of Bioactive Compounds to Improve Skin Cell Responses on Microfabricated Electrospun Microenvironments

Delivery of Bioactive Compounds to Improve Skin Cell Responses on Microfabricated Electrospun Microenvironments

Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Antimicrobial and Antibiofilm Activity of Curcumin-Loaded Electrospun Nanofibers for the Prevention of the Biofilm-Associated Infections

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