Electrospinning and <scp>3D</scp> bioprinting for intervertebral disc tissue engineering

Pieri, Andrea De; Byerley, Ann M.; Musumeci, Catherine R.; Salemizadehparizi, Fatemeh; Vanderhorst, Maya A.; Wuertz‐Kozak, Karin

doi:10.1002/jsp2.1117

Cited by 26 publications

(20 citation statements)

References 110 publications

(187 reference statements)

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“…FFF, also known as fused deposition modeling (patented in 1989 [18]), was developed and utilized for modeling and prototyping to produce complex geometrical, low cost, and easy operation parts. Despite the mentioned advantages of FFF, the quality of the final parts is still a missing point [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

In-Process Monitoring of Temperature Evolution during Fused Filament Fabrication: A Journey from Numerical to Experimental Approaches

Vanaei

Shirinbayan

Deligant

et al. 2021

Thermo

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Fused filament fabrication (FFF), an additive manufacturing technique, unlocks alternative possibilities for the production of complex geometries. In this process, the layer-by-layer deposition mechanism and several heat sources make it a thermally driven process. As heat transfer plays a particular role and determines the temperature history of the merging filaments, the in-process monitoring of the temperature profile guarantees the optimization purposes and thus the improvement of interlayer adhesion. In this review, we document the role of heat transfer in bond formation. In addition, efforts have been carried out to evaluate the correlation of FFF parameters and heat transfer and their effect on part quality. The main objective of this review paper is to provide a comprehensive study on the in-process monitoring of the filament’s temperature profile by presenting and contributing a comparison through the literature.

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Section: Introductionmentioning

confidence: 99%

In-Process Monitoring of Temperature Evolution during Fused Filament Fabrication: A Journey from Numerical to Experimental Approaches

Vanaei

Shirinbayan

Deligant

et al. 2021

Thermo

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“…These technologies could in theory allow the patterning of matrix cues in specific locations and concentrations within bioprintable hydrogel systems. IVD cells have been bioprinted to model NP and AF tissue using shear-thinning hydrogels; however, the development of biochemically and physically relevant printable biomaterials for IVD is a major bottleneck [285], particularly when modelling the stiffer AF region. To address this, hydrogels, including gelatine- [286] and gellan gum-based [287], have been co-printed with PCL scaffolds, increasing the stiffness of the bioprinted constructs.…”

Section: Spatially Controlled Patterning Of Matrix Cues Using Biofabr...mentioning

confidence: 99%

Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration

Kibble

Domingos

Hoyland

et al. 2022

IJMS

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Back pain is one of the leading causes of disability worldwide and is frequently caused by degeneration of the intervertebral discs. The discs’ development, homeostasis, and degeneration are driven by a complex series of biochemical and physical extracellular matrix cues produced by and transmitted to native cells. Thus, understanding the roles of different cues is essential for designing effective cellular and regenerative therapies. Omics technologies have helped identify many new matrix cues; however, comparatively few matrix molecules have thus far been incorporated into tissue engineered models. These include collagen type I and type II, laminins, glycosaminoglycans, and their biomimetic analogues. Modern biofabrication techniques, such as 3D bioprinting, are also enabling the spatial patterning of matrix molecules and growth factors to direct regional effects. These techniques should now be applied to biochemically, physically, and structurally relevant disc models incorporating disc and stem cells to investigate the drivers of healthy cell phenotype and differentiation. Such research will inform the development of efficacious regenerative therapies and improved clinical outcomes.

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“…The near-total degradation of the PLA within 6 months, excellent cell viability (>90%, 7 days) within the GG-PEGDA hydrogels and progressively high levels of F-actin observed through immunostaining after 7 days (indicating good cell spreading through the construct) were all signs that their bioprinted structure would be a highly biomimetic IVD replacement in vivo. Stevens et al provides an overview of the development of GG-based bioinks, while a recent review by Pieri et al provide a more comprehensive review of possible novel bioinks for IVD (Stevens et al, 2016;Pieri et al, 2020). Notwithstanding advances in this field, truly biomimetic IVD replacement/regeneration strategies are only beginning to be researched.…”

Section: Cell-based Bioprinting Of Intervertebral Discsmentioning

confidence: 99%

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

Perera

Ivone

Natekin

et al. 2021

Front. Bioeng. Biotechnol.

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Cartilage defects pose a significant clinical challenge as they can lead to joint pain, swelling and stiffness, which reduces mobility and function thereby significantly affecting the quality of life of patients. More than 250,000 cartilage repair surgeries are performed in the United States every year. The current gold standard is the treatment of focal cartilage defects and bone damage with nonflexible metal or plastic prosthetics. However, these prosthetics are often made from hard and stiff materials that limits mobility and flexibility, and results in leaching of metal particles into the body, degeneration of adjacent soft bone tissues and possible failure of the implant with time. As a result, the patients may require revision surgeries to replace the worn implants or adjacent vertebrae. More recently, autograft – and allograft-based repair strategies have been studied, however these too are limited by donor site morbidity and the limited availability of tissues for surgery. There has been increasing interest in the past two decades in the area of cartilage tissue engineering where methods like 3D bioprinting may be implemented to generate functional constructs using a combination of cells, growth factors (GF) and biocompatible materials. 3D bioprinting allows for the modulation of mechanical properties of the developed constructs to maintain the required flexibility following implantation while also providing the stiffness needed to support body weight. In this review, we will provide a comprehensive overview of current advances in 3D bioprinting for cartilage tissue engineering for knee menisci and intervertebral disc repair. We will also discuss promising medical-grade materials and techniques that can be used for printing, and the future outlook of this emerging field.

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Electrospinning and 3D bioprinting for intervertebral disc tissue engineering

Cited by 26 publications

References 110 publications

In-Process Monitoring of Temperature Evolution during Fused Filament Fabrication: A Journey from Numerical to Experimental Approaches

In-Process Monitoring of Temperature Evolution during Fused Filament Fabrication: A Journey from Numerical to Experimental Approaches

Importance of Matrix Cues on Intervertebral Disc Development, Degeneration, and Regeneration

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

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