Electrospinning and Imaging

Merritt, Sonia R.; Exner, Agata A.; Lee, Zhenghong; Recum, Horst A. von

doi:10.1002/adem.201180010

Cited by 19 publications

(12 citation statements)

References 83 publications

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“…Biocompatible nanofibers prepared by electrospinning serve as artificial three‐dimensional scaffolds which are used in biomedical applications such as controlled drug delivery . The benefit of using electrospinning for drug delivery applications is that it does not destroy the molecular structure and bioactivity of the incorporated drug.…”

Section: Introductionmentioning

confidence: 99%

Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery

et al. 2013

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Silk fibroin from Bombyx mori silk cocoons was electrospun into silk nanofibers (SNFs). SEM images show that 9% w/v of SNFs was smooth and beadless having an average diameter in the range 30-150 nm. Curcumin (0.5-1.5 wt%) was incorporated into the silk fibroin solution and electrospun to obtain curcumin incorporated silk nanofibers (CSNFs) with diameters between 50 and 200 nm. The dispersion of curcumin in the SNFs was confirmed by TEM. The amorphous nature of curcumin upon incorporation into SNFs was confirmed by XRD. The functional groups of SNF and CSNF were confirmed by Fourier transform infrared spectroscopy. The SNFs and CSNFs were thermally stable up to ca 350 • C as evidenced by TGA. The glass transition temperature (T g ) of SNFs (168 • C) increased to 184 • C in the case of CSNFs as confirmed by DSC. The storage modulus, loss modulus and tan δ were determined by dynamic mechanical analysis. The percentages of porosity and water uptake of SNFs were 85% and 150%, respectively. The percentage in vitro cumulative release of curcumin at the end of the tenth day for 0.5, 1 and 1.5 wt% formulations was 82%, 84% and 80%, respectively.

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Section: Introductionmentioning

confidence: 99%

Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery

et al. 2013

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“…FTIR detects resonant frequencies of samples to determine the presence of chemical bonds. In order to detect such frequencies, the sample must be very thin, and as transparent as possible in the infrared spectrum, in order to give a clear spectrum (Merritt et al, 2012). Potassium bromide is spectrally transparent in much of the infrared region, and allows one to create a mostly transparent pellet with small amounts of sample to decrease noise in the reading.…”

Section: Methodsmentioning

confidence: 99%

Adjustable release of mitomycin C for inhibition of scar tissue formation after filtration surgery

Merritt

Velasquez

Recum

2013

Experimental Eye Research

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The aim of this study is to demonstrate a drug delivery system with the capacity to adjust the release of mitomycin C (MMC), based on polymer composition, and inhibit fibroblast proliferation to a better effect than is currently used in glaucoma filtration surgery. The polymer used in this work is made from the oligosaccharide cyclodextrin, from which others and we have demonstrated adjustable release of small molecule drugs due to specific molecular interactions or “affinity” between drug and the cyclodextrin polymer. To adjust release rate, cyclodextrin polymers were synthesized in either dimethylformamide (DMF) or dimethyl sulfoxide, (DMSO) at a crosslinking ratio of 1:0.16 or 1:0:32 (molecule of glucose: molecule of crosslinker). The polymers were then loaded with mitomycin C, dried, and release evaluated in a physiological environment. Drug release was determined by visible spectroscopy. Released aliquots of mitomycin C were incubated with 3T3 fibroblast cells to determine cytotoxic or inhibitory effect through a cell proliferation assay. We show that by using affinity between drug and polymer, we can adjust MMC release rates to be slower and more sustained than from conventional, diffusion-only polymers, for both the DMF polymers (p = 0.00526) and the DMSO polymers (p = 0.0113). The incorporated and released MMC maintains inhibition of fibroblast proliferation much longer than is possible with a one-time application. Affinity polymers with 1:0.16 and 1:0.32 crosslink ratio showed significant inhibition of proliferation for up to 100 h (p = 0.018 and p = 0.014 respectively). The use of our controlled drug delivery technology applied after surgery could have a greater therapeutic impact than the current one-time applications of MMC.

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“…Filtration, wound dressing, fibrous drug delivery, fiber reinforcement of composite materials and support material for catalysts are only very few of a large number of examples. [22]…”

Section: Micro-and Nanofibersmentioning

confidence: 99%

Microplastics – from Anthropogenic to Natural

Hanik¹,

Amstutz²,

Zinn³

2019

Chimia

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In the context of the ongoing discussion of accumulating plastic debris in the environment, this article summarizes recent reports on the topic of microplastic pollution. Moreover, it gives an overview of the results from the activities of the research group for Biotechnology and Sustainable Chemistry of the Institute of Life Technologies at the HES-SO ValaisWallis concerning the fabrication of biodegradable microstructured plastics and microplastics from renewable resources. Polyhydroxyalkanoate biopolyesters are proposed as one suitable alternative in specific applications to reduce the use of persistent plastics. Standard techniques are described that have been successfully applied to produce porous materials, fibers and particles in the micro- and nanometer range.

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Electrospinning and Imaging

Cited by 19 publications

References 83 publications

Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery

Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery

Adjustable release of mitomycin C for inhibition of scar tissue formation after filtration surgery

Microplastics – from Anthropogenic to Natural

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