Electrospinning alginate-based nanofibers: From blends to crosslinked low molecular weight alginate-only systems

Bonino, Christopher A.; Krebs, Melissa D.; Saquing, Carl D.; Jeong, Sunho; Shearer, Kimberly L.; Alsberg, Eben; Khan, Saad A.

doi:10.1016/j.carbpol.2011.02.002

Cited by 236 publications

(176 citation statements)

References 41 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…11) Highly conductive solvents could lead to instability during the electrospinning process, where the electrical field controls the ejection of the polymer solution instead of the feeding rate of the syringe pump. 16) During electrospinning, an imbalance in charge density occurs due to evaporation of the solvents, causing instability in the fiber formation.…”

mentioning

confidence: 99%

Intermolecular Interactions and the Release Pattern of Electrospun Curcumin-Polyvinyl(pyrrolidone) Fiber

Rahma

Munir

Khairurrijal

et al. 2016

Biological & Pharmaceutical Bulletin

157

104

View full text Add to dashboard Cite

An electrospun fiber of polyvinyl(pyrrolidone) (PVP)-Tween 20 (T20) with curcumin as the encapsulated drug has been developed. A study of intermolecular interactions was performed using Raman spectroscopy, Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD).The Raman and FT-IR studies showed that curcumin preferrably interacted with T20 and altered PVP chain packing, as supported by XRD and physical stability data. The hydroxyl stretching band in PVP shifted to a lower wavenumber with higher intenstity in the presence of curcumin and PVP, indicating that hydrogen bond formation is more intense in a curcumin or curcumin-T20 containing fiber. The thermal pattern of the fiber did not indicate phase separation. The conversion of curcumin into an amorphous state was confirmed by XRD analysis. An in vitro release study in phosphate buffer pH 6.8 showed that intermolecular interactions between each material influenced the drug release rate. However, low porosity was found to limit the hydrogen bond-mediated release.Key words curcumin; fiber; electrospinning; interaction; porosity; polymeric drug delivery system Curcumin is the major constituent of turmeric rhizome (Curcuma sp.).1) Curcumin has a number of demonstrated pharmacological effects, such as antioxidant, anti-inflammatory, anticancer, hepatoprotective, 1) antimicrobial, and antiviral. 2)Clinical trials have proven that curcumin is well tolerated by the body, with a maximum dose of 12 g daily.3) Unfortunately, the efficacy of curcumin is limited by its poor solubility in water, as well as its instability under light, heat, and alkaline conditions.1) The solubility of curcumin in aqueous buffer (pH 5) is reported to be 11 ng/mL.3) Moreover, the absorption of curcumin in the gastrointestinal tract is very low, leading to poor bioavailability (in animals and humans).2) Therefore, designing an effective delivery system is necessary in order to address the limitations of curcumin use. 1-3)A wide range of drug delivery systems has been developed to improve the bioavailability of poorly soluble drugs, including fast-dissolving tablets, 4) incorporation into a hydrophilic complex, 1) micellization, and solid dispersion. 5) Electrospinning, a technique of producing thin strands of fiber using high voltage, has opened up opportunities in the development of drug delivery systems. An optimized electrospinning process can produce nano-sized fibers. 6)The high surface area and porosity of these electrospun fibers are advantageous in their use as carriers for poorly water-soluble drugs.5) The high surface area generally increases the dissolution rate of the incorporated drug, thus potentially enhancing its bioavailability. 5)Therefore, the incorporation of curcumin into an electrospun fiber is expected to improve its oral bioavailability.Tailoring a suitable drug-loaded fiber requires careful selection of materials, in addition to an optimized production process and environment. Generally, the drug is mixed with a polymer s...

show abstract

mentioning

confidence: 99%

Intermolecular Interactions and the Release Pattern of Electrospun Curcumin-Polyvinyl(pyrrolidone) Fiber

Rahma

Munir

Khairurrijal

et al. 2016

Biological & Pharmaceutical Bulletin

157

104

View full text Add to dashboard Cite

show abstract

“…Glycol decreased the surface tension and conductivity which contributed to the electrospinnability of pure alginate. Bonino et al [207] tried to electrospin pure alginate using water as a solvent, which resulted in large droplets on the collector, that were reduced by a surfactant. The production of alginate nanofibres from its aqueous solution was also reported by Fang et al [24].…”

Section: Alginatementioning

confidence: 99%

A review on electrospun bio-based polymers for water treatment

Mokhena¹,

Jacobs²,

Luyt³

2015

Express Polym. Lett.

View full text Add to dashboard Cite

Abstract. Over the past decades, electrospinning of biopolymers down to nanoscale garnered much interest to address most of the millennia issues related to water treatment. The fabrication of these nanostructured membranes added a new dimension to the current nanotechnologies where a wide range of materials can be processed to their nanosize. Electrospinning is a simple and versatile technique to fabricate unique nanostructured membranes with fascinating properties for a wide spectrum of applications such as filtration and others. These nanostructured membranes, fabricated by electrospinning, were found to be of a paramount importance because of their advanced inherited properties such as large surface-to-volume ratio, as well as tuneable porosity, stability, and high permeability. The extensive research conducted on these materials extended the success of electrospinning not only to bio-based polymer nanofibres, but to their hybrids and their derivatives. The technique also created avenues for advanced and massive production of nanofibres. This paper reviews the recent developments in the electrospinning technique. Electrospinning of biopolymers, their blends and functionalization using metals/metal oxides, and the potential applications of electrospun nanofibrous membranes in water filtration are discussed.

show abstract

“…Even at concentrations below gelation, insufficient polymer chains as well as intermolecular repulsion between anionic groups hinder chain entanglement required for fiber formation. Electrospinning of sodium alginate (SA) has only been possible from either solutions in organic solvents (Bhattarai et al, 2006;Nie et al, 2008) or aqueous mixtures containing synthetic water-soluble polymers, such as poly(vinyl alcohol) (PVA) (Islam & Karim, 2010;Lee et al, 2007;Safi, Morshed, Hosseini Ravandi, & Ghiaci, 2007;Shalumon et al, 2011) and poly(ethylene oxide) (PEO) (Alborzi, Lim, & Kakuda, 2010;Bhattarai et al, 2006;Bonino et al, 2011;Kong, Yu, Ji, & Xia, 2009;Lu, Zhu, Guo, Hu & Yu, 2006;Ma, Fang, Liu, Zhu, & Nie, 2012;Nie et al, 2009;Safi et al, 2007;Zhang, 2007). From aqueous media, uniform fibers with SA as the dominant polymer could only be electrospun from mixtures with PEO.…”

Section: Introductionmentioning

confidence: 99%

“…From aqueous media, uniform fibers with SA as the dominant polymer could only be electrospun from mixtures with PEO. In cases where 80% SA have been electrospun with PEO, attempts to cross-link SA/PEO fibers with CaCl 2 failed to retain the fiber structure which had became filmlike from either crosslinking or after subsequent water immersion (Bonino et al, 2011;Lu et al, 2006;Ma et al, 2012). Electrospinning SA in aqueous mixtures with PVA, on the other hand, has produced highly beaded fibers at up to 50% SA and none crosslinked.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible sodium alginate fibers by aqueous processing and physical crosslinking

Shen

Hsieh

2014

Carbohydrate Polymers

View full text Add to dashboard Cite

and their mixtures showed fiber spinning to be strongly influenced by the balance between SA-PVA and PVA-PVA intermolecular polar interaction and SA-SA repulsion. Low viscosity SA l (50 mPa s at 1%) enabled higher SA loadings without significantly increasing mixture viscosities, producing more cylindrical fibers. All aqueous mixtures containing 33.3-60% SA l (5.68-7.15% total SA l -PVA) had viscosities ranging from 530 to 3600 mPa s and could be electrospun continuously for at least 48 h. The SA-PVA hybrid fibers had diameters ranging from ca. 140 to 350 nm and were rendered stable in water via simultaneous ionic-crosslinking SA and crystallization of PVA (5% CaCl 2 in 75% EtOH for 30 min). This aqueous electrospinning and physical crosslinking approach is a green and highly efficient alternative to create alginate hybrid fibers that are biologically compatible and ingestible for potential biomedical, food and other applications.

show abstract

Electrospinning alginate-based nanofibers: From blends to crosslinked low molecular weight alginate-only systems

Cited by 236 publications

References 41 publications

Intermolecular Interactions and the Release Pattern of Electrospun Curcumin-Polyvinyl(pyrrolidone) Fiber

Intermolecular Interactions and the Release Pattern of Electrospun Curcumin-Polyvinyl(pyrrolidone) Fiber

A review on electrospun bio-based polymers for water treatment

Biocompatible sodium alginate fibers by aqueous processing and physical crosslinking

Contact Info

Product

Resources

About