Electroretinographic and Optical Coherence Tomographic Evaluations of Eyes with Vitreoretinal Lymphoma

Makita, Jun; Yoshikawa, Yuji; Kanno, Junji; Igawa, Yuro; Kumagai, Tomoyuki; Takano, Shigeru; Katsumoto, Takeshi; Shoji, T.; Shibuya, Masayuki; Shinoda, Kei

doi:10.3390/jcm12123957

Cited by 1 publication

(2 citation statements)

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“…They are thought to be due to the infiltration of malignant lymphoma cells into the retina. Sub-RPE deposits, also found in our case, have mainly been examined with OCT [ 5 , 8 , 14 ] and AF [ 15 ] Pierro et al [ 7 ] firstly described their appearance on SS-OCT-A as multiple hyperreflective spots on enface outer retina slabs and SS-OCT-A analysis, thus interpretable as a movement signal provided by white cell infiltration. Similarly, in our case, sub-RPE deposits appeared hyperreflective on enface SS-OCT-A outer retina slabs (Fig.…”

Section: Discussionmentioning

confidence: 92%

“…Considering the invasive nature of the procedures for a VRL diagnosis, better knowledge of multimodal imaging features of the disease would be desirable to increase pre-test probability. Previous studies described several VRL features [ 5 , 14 , 15 ]. However, few studies have reported SS-OCT-A findings, and their long-term follow-up remains unexplored.…”

Section: Discussionmentioning

confidence: 99%

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Swept-source optical coherence tomography angiography findings in a case of primary vitreoretinal lymphoma over a three-year follow-up

Maggio,

Bauci,

Polito

et al. 2024

BMC Ophthalmol

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Background Vitreoretinal lymphoma (VRL) still represents a diagnostic challenge for retinal specialists. Early diagnosis and treatment are critical for a better prognosis. Several diagnostic tools have proven helpful in the identification of VRL abnormalities. However, swept-source OCT angiography (SS-OCT-A) findings and their long-term follow-up are yet to be explored. Case presentation a 42-year-old man presented with blurred vision in his left eye for 2 weeks. He denied any systemic symptoms. A multimodal imaging examination was performed, raising the clinical suspicion of VRL and guiding the ensuing diagnostic procedures. The patient underwent treatment and at the last FU visit three years later, no disease signs were present on fundus examination, nor on oncologic evaluation. Some novel SS-OCT-A features were identified, and uncommonly reported findings were examined over a long-term follow-up. At baseline multiple hyperreflective alterations were detected on the enface outer retina slabs and choriocapillary analysis revealed low reflectance areas in the foveal and parafoveal areas. One month after the first presentation, multiple hyperreflective retinal lesions in a vertical shape were detected on OCT which appeared on midretinal slabs of enface SS-OCT-A as hyperreflective spots mainly located near second-order retinal vessels. These alterations remarkably reduced after treatment. Conclusion SS-OCT-A may be a useful imaging technique in the detection of VRL, providing ophthalmologists additional findings that assist the diagnosis and follow-up of this disease. This may prove useful for a more timely and precise diagnosis, prompt therapy, and treatment response monitoring. The original aspects found in this case may provide grounds for future studies, ultimately fostering a better understanding of the disease.

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