Electroregenerable anion-exchange resin with triiodide carbon paste electrode for the voltammetric determination of adrenaline

Abstract

An electroregenerable carbon paste electrode modified with triiodide ions immobilized in an anion-exchange resin (Lewatit M500) is proposed for the determination of adrenaline in pharmaceutical products by differential-pulse voltammetry (DPV). Adrenaline was chemically converted into adrenochrome by the I3- ions at the electrode surface. The electrochemical reduction back to adrenaline was obtained at a potential of -0.16 V vs. Ag/AgCl (3 mol l(-1) KCl). A 20% decrease of the initial analytical signal was observed after 350-400 determinations; the carbon paste electrode was 100% electroregenerated at a fixed potential of +0.65 V vs. Ag/AgCl (3 mol l(-1) KCl) in 0.1 mol l(-1) KI solution for 20 min. The differential-pulse voltammograms were obtained by applying a sweep potential between 0.0 and -0.34 V, following the adrenochrome reduction at -0.16 V. Under the optimum conditions established, such as pH 6.0; scan rate 20 mV s(-1) and pulse amplitude 50 mV, the calibration curve was linear from 2.0 x 10(-5) to 3.1 x 10(-4) mol l(-1) adrenaline with a detection limit of 3.9 x 10(-6) mol l(-1). The recovery of adrenaline ranged from 99.8 to 103.1% and the RSD was 2.6% for the solution containing 1.0 x 10(-4) mol l(-1) adrenaline (n = 10). The results obtained for adrenaline in pharmaceutical samples using the proposed carbon paste electrode are in agreement with those obtained using a pharmacopoeial procedure at the 95% confidence level.

Graphite paste electrode modified with Lewatit® FO36 nano-resin for simultaneous determination of ascorbic acid, acetaminophen and tryptophan

“…41 Lupetti et al used anionexchange resin with a triiodide carbon paste electrode for the determination of adrenaline. 42 To the best of our knowledge, no study has been reported on the electroanalysis and simultaneous determination of AA, AC and Trp using a modied graphite paste electrode with LFOR. This paper introduces for the rst time a simple method for the preparation of a new modied graphite paste electrode based on LFOR dispersed in paraffin.…”

Electrochemical behavior of isoproterenol in the presence of uric acid and folic acid at a carbon paste electrode modified with 2,7-bis(ferrocenyl ethyl)fluoren-9-one and carbon nanotubes

“…Also, IP should not be administered to patients with myocardial ischemia. Several methods have been described in the literature for the determination of IP such as flow injection spectrophotometry [3], ultra-performance liquid chromatography/timeof-flight mass spectrometry [4], and capillary electrophoresis [5]. Due to the advantages of relatively low cost, fast response, simple instrumentation, high sensitivity, facile miniaturization, and low power requirement, numerous voltammetric methods have been developed for the determination of IP [2, [6][7][8].…”

Flow injection spectrophotometric determination of adrenaline using a solid-phase reactor containing triiodide ions immobilized in an anion-exchange resin

“…In the immobilization of triiodide ion (I 3 -), the resin conversion was carried out in a glass column, as described previously [23] and shown in Figure 2.…”