Electroreductive Cross-Coupling between Aromatic Aldehydes and Chlorosilanes Enabling the Synthesis of α-Silyl Alcohols
Fen Han,
Qian Su,
Yu Li
et al.
Abstract:α-Silyl alcohols are powerful structural motifs
for pharmaceutical
chemistry, materials chemistry, and organic synthesis. The limitations
of current synthetic techniques encompass a requirement for difficult-to-obtain
silyl precursors, noble-metal catalysts, and narrow substrate scopes.
Here, we developed a general synthetic method for α-silyl alcohols
through electroreductive cross-coupling of aldehydes and chlorosilane.
This method features easily available reagents, mild conditions, and
a wide substrate sco… Show more
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