Electroreduction of β-hydroxy phenyl sulfones in acetonitrile

Cryo-electrochemistry in tetrahydrofuran: The regioselective electrochemical reduction of a phenyl sulfone: Fast-scan cyclic voltammetry investigations

“…One of the most well-known examples of this is the Julia olefination, involving the reaction of an aryl sulfone with a carbonyl derivative followed by reductive elimination to give an alkene [19]. In electrochemistry, the reduction of alkyl-or aryl-sulfonylbenzenes was the subject of numerous investigations in both aqueous and non-aqueous media [22][23][24][25][26][27][28][29][30][31][32][33]. The mechanism of sulfone reactivity following electron transfer under electrochemical conditions was the subject of much research and debate [24,25,31,34,35].…”

Visible-Light-Driven Sulfonation of α-Trifluoromethylstyrenes: Access to Densely Functionalized CF3-Substituted Tertiary Alcohol

“…Trifluoromethylated compounds are pervasive motifs embedded in a wide range of pharmaceuticals, agrochemicals, and materials, owing to their unique electronegativity, lipophilicity, metabolic stability, and bioavailability . Among them, CF 3 -substituted tertiary alcohols and their derivatives are present in a range of therapeutic drugs and synthetic intermediates. , Accordingly, a plethora of synthetic protocols for accessing CF 3 -substituted tertiary alcohols have been established . Generally, direct addition of nucleophiles to trifluoromethyl ketones or nucleophilic trifluoromethylation of ketones occupies the mainstream, wherein employment of organometallic reagents or cryogenic reaction conditions frequently limited their wide and practical utilizations.…”