Electropotentials of normal tissue

Schauble, Muriel K.; Habal, Mutaz B.

doi:10.1016/0022-4804(69)90126-7

Cited by 11 publications

(15 citation statements)

References 2 publications

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“…The BALB/c mice were inoculated with 0.25 ml 4.0×10 6 Colon 26 cells/ml by intradermal injection in the abdomen. A palpable, single solid tumor was produced within 7 days.…”

Section: Experimental Tumormentioning

confidence: 99%

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Pharmacodynamics induced by direct electric current for the treatment of 5-fluorouracil resistant tumor: an animal experiment

Ito

Wong

Ando

et al. 2001

Int J Colorectal Dis

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The repeated use of chemotherapy to treat patients with colorectal carcinoma may be limited by the fact it creates resistance cells. However, we have observed a remarkable decrease in certain types of drug resistance in patients treated with direct electric current. Experimental studies were therefore performed in animals to determine the differences in pharmacodynamics between chemotherapy with and that without electric treatment. Tumors were created in BALB/c mice by intradermal injection of 0.25 ml 4 x 10(6) Colon 26 cells/ml in the abdomen. Seven days later the mice were divided into two groups: controls and those that underwent electric treatment. Direct electric current (1,000 V, 0.2-0.8 microA) was passed between a platinum electrode inserted intradermally and the earth during and for 1 h after a single intravenous injection of 5-fluorouracil (5-FU; 12.5 mg ml(-1) kg(-1)). Peripheral blood samples were collected before and 5, 10, 20, 30, 45, and 60 min after the injection of 5-FU. Concentrations of 5-FU in the sera and tissues were measured by HPLC. The intratumoral concentrations of 5-FU in the electric treatment group were higher than those in the controls (P<0.05, two-factor analysis of variance), but the serum concentrations were not statistically different between the two groups. Pharmacodynamic changes were thus observed as a result of electrostatic treatment during chemotherapy. This elevated 5-FU concentration in the tumor tissue is considered one of the reasons for the effective inhibition of 5-FU resistance in clinical cases.

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“…The BALB/c mice were inoculated with 0.25 ml 4.0×10 6 Colon 26 cells/ml by intradermal injection in the abdomen. A palpable, single solid tumor was produced within 7 days.…”

Section: Experimental Tumormentioning

confidence: 99%

“…Tumor tissues possess a more negative surface electropotential than normal tissue in both experimental animals and humans, and the degree of electronegativity may be directly correlated with the degree of biological malignancy and differentiation of the tumor [5,6,7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Pharmacodynamics induced by direct electric current for the treatment of 5-fluorouracil resistant tumor: an animal experiment

Ito

Wong

Ando

et al. 2001

Int J Colorectal Dis

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“…• Cancerous tissues and less differentiated regenerating tissues are more electronegative than normal cells and normal tissues (Ambrose et al, 1969;Schaubel et al, 1970;Becker, 1985). • Cone reported in 1975 that the electrical potential of cancer cell membranes was significantly less than the membrane electrical potential of healthy cells.…”

Section: Pathology Of the Ecmmentioning

confidence: 99%

Cancer: The ultimate plan

Hague¹

2019

Gen Med Open

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Introduction 2. Electricity, charge carriers and electrical properties of cells. 3. Cellular electrical properties and electromagnetic fields (EMF). 4. Attunement. 5. More details about the electrical roles of membranes and mitochondria. 6. What structures are involved in cancerous transformation? 7. Electronic roles of the cell membrane and the electrical charge of cell surface coats. 8. Cells actually have a number of discrete electrical zones. 9. The electrical properties of cancer cells part 1. 10. The electrical properties of cancer cells part 2. 11. Anatomical concepts • The intravascular space and its components • The cell membrane covering of cells and the attached glycocalyx: Chemical and anatomical roles of the cell membrane. • The extracellular space and the components of the extracellular matrix (ECM) connect to the cytoskeleton of the cells: The electronic functions of the cells and the ECM are involved in healing and tissue regeneration. • The ECM-glycocalyx-membrane interface • The intracellular space 12. Signaling mechanisms may be either chemically or resonantly mediated. 13. Resonance communication mechanisms. 14. The Bioelectrical control system. 15. Electrical properties of the ECM 16. Pathology of the ECM. 17. Mineral and water abnormalities in cancerous and injured tissues: sodium, potassium, magnesium and calcium: their effect on cell membrane potential. 18. Tumor cell differentiation, tumor hypoxia and low cellular pH can affect: gene expression, genetic stability, genetic repair, protein structures, protein activity, intracellular mineral concentrations, and types of metabolic pathways used for energy production. 19. Tumor cells express several adaptations in order to sustain their sugar addiction and metabolic strategies to address this issue. 20. Tumor acidification versus tumor alkalization. 21. The pH of the intracellular and extracellular compartments will also affect the intracellular potassium concentration. 22. Tumor cell coats contain human chorionic gonadotropin and sialic acid as well as negatively charged residues of RNA, which give tumor cells a strong negative charge on their cell surface. 23. Biologically Closed Electric Circuits. 24. Bacteria and viruses in cancer. 25. Treatment devices. 26. Polychromatic states and health: a unifying theory? 27. Treatment Section: Topics to be covered on the electrical properties of cancer cells pH changes Mineral changes Structural membrane changes Membrane potential changes Extracellular matrix changes Protein changes Gene changes Sialic acid-tumor coats-negative charge Sialic acid in viral coats and role of drugs, blood electricfication, nutrients to change infectivity

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“…The electrical properties and active bioelectricity inherent in cancer and surrounding healthy tissue are experimentally confirmed by means of several techniques, such as: bioelectrical impedance analysis [6], image technique of the electric current density [7], microelectrodes and neutralized input capacity amplifiers, high-impedance micropipettes, potentiometry, fluorescence, electrical double layer in fieldeffect transistors, electrical impedance spectroscopy together with other devices [8][9][10][11][12][13][14]. Additionally, vibrating probes, glass microelectrodes, microfluidic-based tissue/organ-on-a-chip devices, and endoscopes with inserted electronics to detect bioelectricity changes in real-time are recommended.…”

Section: Introductionmentioning

confidence: 99%

“…Several findings have been revealed, such as: (1) differences between electrical conductivities (η k , k = 1,2) and electrical permittivities (ε k , k = 1,2) of the untreated malignant tumour (k = 1) and the surrounding healthy tissue (k = 2) [11]; (2) these two physical properties as a potential diagnostic method [16]; (3) differences between ionic current (due to the movement of charged ions) and faradic current (produced by electrons exchange from reduction and/or oxidation of biochemical molecules) in cancer and surrounding healthy tissue [8]; (4) the existence of chemical and electrical (charged negatively) environments in cancer cells and untreated tumours [1,4,14] and their key roles in the genesis, growth, progression, metastasis and treatment of cancer [17]; (5) the impact of tumour microenvironment on its electrical properties [16]; (6) the breakdown of intercellular communication (gap junction) in the tumour due to low regulation in expression of the connexin [12,18]; (7) negative electrical biopotentials in the tumour and positive electrical biopotentials in the surrounding healthy tissue [12][13][14]; (8) cancer cells and some cells of the immune system negatively charged [14]; (9) weaker electrical coupling among cancer cells and the association of deregulation of intercellular communication with tumourigenicity and metastasis of the cancer [14,18]; (10) bioelectronic cancer regulator as an initiator of the mitosis and deoxyribonucleic acid synthesis; and (11) correction of alterations in the electrical communication system of cancer by manipulating its bioelectrical properties, known as bioelectronic medicine [8].…”

Section: Introductionmentioning

confidence: 99%

Simulations of surface charge density changes during the untreated solid tumour growth

et al. 2022

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Understanding untreated tumour growth kinetics and its intrinsic behaviour is interesting and intriguing. The aim of this study is to propose an approximate analytical expression that allows us to simulate changes in surface charge density at the cancer-surrounding healthy tissue interface during the untreated solid tumour growth. For this, the Gompertz and Poisson equations are used. Simulations reveal that the unperturbed solid tumour growth is closely related to changes in the surface charge density over time between the tumour and the surrounding healthy tissue. Furthermore, the unperturbed solid tumour growth is governed by temporal changes in this surface charge density. It is concluded that results corroborate the correspondence between the electrical and physiological parameters in the untreated cancer, which may have an essential role in its growth, progression, metastasis and protection against immune system attack and anti-cancer therapies. In addition, the knowledge of surface charge density changes at the cancer-surrounding healthy tissue interface may be relevant when redesigning the molecules in chemotherapy and immunotherapy taking into account their polarities. This can also be true in the design of completely novel therapies.

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Electropotentials of normal tissue

Cited by 11 publications

References 2 publications

Pharmacodynamics induced by direct electric current for the treatment of 5-fluorouracil resistant tumor: an animal experiment

Pharmacodynamics induced by direct electric current for the treatment of 5-fluorouracil resistant tumor: an animal experiment

Cancer: The ultimate plan

Simulations of surface charge density changes during the untreated solid tumour growth

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