Electrophysiologically verified effects of acupuncture on diabetic peripheral neuropathy in type 2 diabetes: The randomized, partially double‐blinded, controlled ACUDIN trial

Meyer-Hamme, Gesa; Friedemann, Thomas; Greten, Henry Johannes; Gerloff, Christian; Schroeder, Sven

doi:10.1111/1753-0407.13130

Cited by 26 publications

(34 citation statements)

References 42 publications

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“…As shown in a previous review, this can also lead to new technological systems to measure TCM-related effects, and to calibrate and mimic complex and skillful diagnosis procedures [ 211 ]. A second crucial factor is the further development of experimental approaches in TCM research, such as the double-blinding of acupuncture trials [ 120 , 134 , 135 , 136 , 137 ] and the development of a placebo for “Qigong” research [ 212 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that major effects of acupuncture have now also been confirmed by prospective randomized and even double-blinded clinical trials [ 120 , 134 , 135 , 136 , 137 ].…”

Section: Acupuncture Moxibustion and Cuppingmentioning

confidence: 99%

“…As shown by Chan et al (2018), while evaluating the effects of acupuncture and moxibustion on the electrophysiological properties of the ulnar nerve, the stimulation of HT4 increased the electrical sensitivity and decreased the stimulus intensity to achieve the maximum amplitude, and avoided a significant increase in latency and decrease in reaction velocity in two consecutive electrical stimulations [ 119 ]. Using the same assessment strategy on diabetic peripheral neuropathy (DPN) in type 2 diabetes patients, Meyer et al (2020) found that classical needle acupuncture had significant effects on DPN, and that improvements in NCS values presumably indicate structural neuroregeneration following acupuncture [ 120 ].…”

Section: Acupuncture Moxibustion and Cuppingmentioning

confidence: 99%

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Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications

et al. 2021

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Traditional Chinese medicine (TCM) is a systematic healthcare system developed from clinical experience based on a scientific model of regulation. TCM relies on unique theories and practices to treat diseases and enhance health. These practices include Chinese herbal medicine and dietetics, acupuncture and moxibustion, and other non-medication therapies such as Chinese bodywork or manual therapy, known as “Tuina”, and traditional biofeedback exercises, known as “Qigong” and “Taijiquan”. The integration of TCM in Western health systems and research requires a rational communicable theory, scientific proof of efficacy and safety, and quality control measures. Understanding the structural concepts of the TCM language makes possible the parallelism to Western physiology, and the inherent rational use of the reflex therapeutic systems, anti-inflammatory mechanisms and mental training involved, for example, in acupuncture and “Qigong”. The results of TCM clinical trials and fundamental research on its nature and mechanisms have encouraged the development and application of well-designed research strategies such as double blinding in acupucture to overcome limitations and resistances in integrating these practices into the existing biomedical paradigms of the West. This review aims to overview some TCM theoretical concepts and the evidence-based clinical application of TCM’s leading practices to create an easy-to-consult and condensed source of information, available for the healthcare community, facilitating the understanding and communication between conventional health professionals and TCM practitioners and acupuncturists.

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Section: Discussionmentioning

confidence: 99%

“…It is noteworthy that major effects of acupuncture have now also been confirmed by prospective randomized and even double-blinded clinical trials [ 120 , 134 , 135 , 136 , 137 ].…”

Section: Acupuncture Moxibustion and Cuppingmentioning

confidence: 99%

Section: Acupuncture Moxibustion and Cuppingmentioning

confidence: 99%

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Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications

et al. 2021

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“…A sensory nerve conduction study (NCS) revealed that acupuncture increased the nerve conduction velocity (NCV) in the median and peroneal nerves. In a recently published RCT, 172 patients with diabetic neuropathy received 10 acupuncture treatments or 10 laser acupuncture or 10 placebo laser treatments; sural SNAP and sural and tibial NCV improved significantly when comparing needle acupuncture to placebo [12]. Neuropathies with different etiology have been investigated in the past.…”

Section: Background and Rationale {6a}mentioning

confidence: 99%

Acupuncture in diabetic peripheral neuropathy—protocol for the randomized, multicenter ACUDPN trial

Dietzel

Hörder

Habermann

et al. 2021

Trials

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Background Acupuncture is used to treat patients with diabetic peripheral neuropathy; however, the evidence is unclear. We present the design and methodology of the ACUDPN (ACUpuncture in Diabetic Peripheral Neuropathy) trial, which investigates the effectiveness of acupuncture for the treatment of diabetic peripheral neuropathy (DPN) symptoms. The aim of this study is to investigate whether acupuncture is effective for the treatment of DPN symptoms. Methods This study is a two-armed, randomized, controlled, parallel group, open-label, confirmatory, multicenter trial (8-week intervention period plus 16 weeks of follow-up). Physicians in outpatient units in Germany who specialize in acupuncture treatment will treat 110 diabetes type II patients with clinical symptoms of peripheral neuropathy in the feet and legs with signs of neuropathy according to nerve conduction testing. The patients will be randomized in a 1:1 ratio to one of the following two groups: (a) semi-standardized acupuncture plus routine care or (b) routine care alone. Acupuncture will consist of 12 treatments per patient over 8 weeks. The primary outcome will be the overall DPN-related complaints in the extremities after 8 weeks as measured by the Visual Analog Scale (VAS). Further outcome measures will include DPN-related pain, the Neuropathic Pain Symptom Inventory (NPSI), Diabetic Peripheral Neuropathic Pain Impact (DPNPI) scores, and nerve conduction parameters of the sural nerve at weeks 8, 16, and 24. Discussion The results of this trial will be available in 2021 and will help clarify whether acupuncture can be considered effective for the treatment of DPN with regard to the subdimensions of the neuropathic clinical picture. Trial registration ClinicalTrials.gov NCT03755960. Registered on 11 August 2018.

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“…A sensory nerve conduction study (NCS) revealed that acupuncture increased the nerve conduction velocity (NCV) in the median and peroneal nerves. In a recently published RCT, 172 patients with diabetic neuropathy received 10 acupuncture treatments or 10 laser acupuncture or 10 placebo laser treatments; sural SNAP and sural and tibial NCV improved signi cantly when comparing needle acupuncture to placebo [12]. Neuropathies with different etiology have been investigated in the past.…”

mentioning

confidence: 99%

Acupuncture in Diabetic Peripheral Neuropathy - Protocol for the Randomized, Multicenter ACUDPN Trial.

Dietzel

Hörder

Habermann

et al. 2021

Preprint

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Background: Acupuncture is used to treat patients with diabetic peripheral neuropathy; however, the evidence is unclear. We present the design and methodology of the ACUDPN (ACUpuncture in Diabetic Peripheral Neuropathy) trial, which investigates the effectiveness of acupuncture for the treatment of diabetic peripheral neuropathy (DPN) symptoms. The aim of this study is to investigate whether acupuncture is effective for the treatment of DPN symptoms.Methods: This study is a two-armed, randomized, controlled, parallel group, open-label, confirmatory, multicenter trial (8-week intervention period plus 16 weeks of follow-up). Physicians in outpatient units in Germany who specialize in acupuncture treatment will treat 110 diabetes type II patients with clinical symptoms of peripheral neuropathy in the feet and legs with signs of neuropathy according to nerve conduction testing. The patients will be randomized in a 1:1 ratio to one of the following two groups: (a) semi-standardized acupuncture plus routine care or (b) routine care alone. Acupuncture will consist of 12 treatments per patient over 8 weeks. The primary outcome will be the overall DPN-related complaints in the extremities after 8 weeks as measured by the Visual Analog Scale (VAS). Further outcome measures will include DPN-related pain, the Neuropathic Pain Symptom Inventory (NPSI), Diabetic Peripheral Neuropathic Pain Impact (DPNPI) scores and nerve conduction parameters of the sural nerve at weeks 8, 16 and 24.Discussion: The results of this trial will be available in 2021 and will help clarify whether acupuncture can be considered effective for the treatment of DPN with regard to the subdimensions of the neuropathic clinical picture.Trial registration: ClinicalTrials.gov: NCT03755960. Registered on November 19, 2018, https://clinicaltrials.gov/ct2/show/study/NCT03755960.

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Electrophysiologically verified effects of acupuncture on diabetic peripheral neuropathy in type 2 diabetes: The randomized, partially double‐blinded, controlled ACUDIN trial

Cited by 26 publications

References 42 publications

Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications

Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications

Acupuncture in diabetic peripheral neuropathy—protocol for the randomized, multicenter ACUDPN trial

Acupuncture in Diabetic Peripheral Neuropathy - Protocol for the Randomized, Multicenter ACUDPN Trial.

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