Electrophysiological study on the postnatal development of mitral cell activity in the rat olfactory bulb

Math, François; Davrainville, J.L.

doi:10.1016/0006-8993(80)91174-9

Cited by 53 publications

(15 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Spontaneous activity was much greater in mature rats than in infants. This is consistent with other reports of mitral/tufted cell activity increasing with age (Math and Davrainville, 1980;Shafa et al, 1981;Wilson and Leon, 1986). Similarly, odorants appeared to elicit more robust responses in mature rats as measured by instantaneous firing rates.…”

Section: Olfactory Bulb Mitral/tufted Cell Activity Differs Between Asupporting

confidence: 92%

High-Frequency Oscillations Are Not Necessary for Simple Olfactory Discriminations in Young Rats

Fletcher¹,

Smith²,

Best³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

Individual olfactory bulb mitral/tufted cells respond preferentially to groups of molecularly similar odorants. Bulbar interneurons such as periglomerular and granule cells are thought to influence mitral/tufted odorant receptive fields through mechanisms such as lateral inhibition. The mitral-granule cell circuit is also important in the generation of the odor-evoked fast oscillations seen in the olfactory bulb local field potentials and hypothesized to be an important indicator of odor quality coding. Infant rats, however, lack a majority of these inhibitory interneurons until the second week of life. It is unclear if these developmental differences affect olfactory bulb odor coding or behavioral odor discrimination. The following experiments are aimed at better understanding odor coding and behavioral odor discrimination in the developing olfactory system. Single-unit recordings from mitral/tufted cells and local field-potential recordings from both the olfactory bulb and anterior piriform cortex were performed in freely breathing urethane-anesthetized rats (postnatal day 7 to adult). Age-dependent behavioral odor discrimination to a homologous series of ethyl esters was also examined using a crosshabituation paradigm. Odorants were equated in all experiments for concentration (150 ppm) using a flow dilution olfactometer. In concordance with the reduced interneuron population, local field potentials in neonates lacked detectable odor-evoked ␥-frequency oscillations that were observed in mature animals. However, mitral/tufted cell odorant receptive fields and behavioral odor discrimination did not significantly change, despite known substantial changes in local circuitry and neuronal populations, over the age range examined. The results suggest that high-frequency local field-potential oscillations do not reflect processes critical for simple odor discrimination.

show abstract

Section: Olfactory Bulb Mitral/tufted Cell Activity Differs Between Asupporting

confidence: 92%

High-Frequency Oscillations Are Not Necessary for Simple Olfactory Discriminations in Young Rats

Fletcher¹,

Smith²,

Best³

et al. 2005

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…This assumption is supported by electrophysiological and morphological data in olfactory and visual channels of neonatally undernourished rats [Salas et al. 1977;Math and Davrainville, 1980). suggesting an impairment in the sensorial integrating mechanisms underlying selective attention and perceptual phenomena.…”

Section: Discussionsupporting

confidence: 63%

Dendritic Arbor Alterations in the Medial Superior Olivary Neurons of Neonatally Underfed Rats

Salas¹,

Torrero²,

Regalado³

et al. 1994

Cells Tissues Organs

View full text Add to dashboard Cite

Golgi-Cox-stained bipolar cells of the medial superior olive (MSO) were analyzed in control and undernourished Wistar strain rats at 12, 20, 30 and 40 days of age. Undernutrition significantly reduced the number of dendrites and the extension of ipsilateral dendritic prolongations, with no effects upon the cross-sectional somal area and minimal alterations in the corresponding contralateral dendritic branches. The data suggest that in underfed rate, afferents from the receptors projecting to the MSO via the anteroventral cochlear nuclei may cause an imbalance in the binaural interactions which occur between the axon terminals and the ipsilateral and contralateral dendritic arbors of MSO neurons.

show abstract

“…Such changes may evoke activity-dependent down-regulation of IP 3 R expression in projection neurons. Findings that both spontaneous (Math and Davrainville, 1980) and odor-evoked (Mair and Gesteland, 1982) activity patterns in mitral cells change during the period of inhibitory circuitry development are consistent with this possibility. Also consistent with this are reports by Wojcikiewicz and colleagues on activity-dependent down-regulation of IP 3 Rs in a variety of cell types (see, e.g., Wojcikiewicz and Oberdorf, 1996).…”

Section: Ip 3 R Expression During Developmentsupporting

confidence: 72%

Differential distribution of inositol 1,4,5-triphosphate receptors in the rat olfactory bulb

1997

View full text Add to dashboard Cite

The inositol 1,4,5-triphosphate receptor (IP3R) regulates the release of calcium from intracellular stores. In the present study, the distribution of IP3R in the rat main olfactory bulb was determined by immunohistochemistry. Immunofluorescence was used to double label for IP3R and for gamma-aminobutyric acid (GABA) or for projection neurons, which were retrogradely labeled following dextran injection into the lateral olfactory tract (LOT). The expression profile of IP3R changes dramatically during development. In the glomerular layer of adults, many juxtaglomerular neurons are IP3R immunoreactive [IP3R(+)]; the majority of these cells are also GABA immunoreactive [GABA(+)]. Scattered sparsely throughout the external plexiform layer are small numbers of IP3R(+) neurons, a small number of which are LOT-projecting tufted cells. Significant numbers of IP3R(+) neurons are in the granule cell layer; however, most of these cells are GABA(-). The vast majority of mitral cells contain little or no IP3R immunoreactivity. These findings indicate that, in the olfactory bulb of adult rats, IP3R is preferentially localized in specific classes of intrinsic neurons and that it is rarely expressed in projection neurons. In contrast, during the first postnatal week, the receptor is detected almost exclusively in mitral cells. Expression of IP3R in subclasses of intrinsic neurons begins during the second and third weeks, concomitant with a decrease in immunostaining of mitral cells. Adult patterns of IP3R immunostaining are apparent by the fourth postnatal week. These observations raise the possibility that the expression of IP3R in specific classes of neurons during development is activity dependent.

show abstract

Electrophysiological study on the postnatal development of mitral cell activity in the rat olfactory bulb

Cited by 53 publications

References 9 publications

High-Frequency Oscillations Are Not Necessary for Simple Olfactory Discriminations in Young Rats

High-Frequency Oscillations Are Not Necessary for Simple Olfactory Discriminations in Young Rats

Dendritic Arbor Alterations in the Medial Superior Olivary Neurons of Neonatally Underfed Rats

Differential distribution of inositol 1,4,5-triphosphate receptors in the rat olfactory bulb

Contact Info

Product

Resources

About