Electrophysiological study on the postnatal development of mitral cell activity in the rat olfactory bulb. Influence of undernutrition

Math, François; Davrainville, J.L.

doi:10.1016/0006-8993(80)91333-5

Cited by 27 publications

(15 citation statements)

References 11 publications

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“…The finding of significant reductions in body and brain weights concurrent with ear-and-eye-opening delays throughout the study is in line with previous reports showing that different perinatal underfeeding paradigms consistently interfere with food intake, physical growth, low emission of vocalizations and poor maternal care and delayed sensory maturation, particularly in the olfactory channel when the mother-litter bonds are at a critical stage and are essential for the pups' survival and brain growth (Salas et al 1970, Math and Davrainville 1980, Salas et al 1984, Almli et al 1985, Alberts and Cramer 1988, Diaz-Cintra et al 1994, Fleming et al 1999, Torrero et al 2000, Tonkiss et al 2003, Rubio et al 2004). …”

Section: Physical Developmentsupporting

confidence: 87%

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Organization of olfactory glomeruli in neonatally undernourished rats

Frías

Torrero

Regalado

et al. 2006

Nutritional Neuroscience

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Newborn rats maintain mother-litter bonds by using olfactory signals. At birth, units in the olfactory glomeruli (OG) are immature and vulnerable to noxious epigenetic factors like undernutrition. Because little is known about the effects of neonatal undernutrition upon the OG morphological organization, different OG parameters were studied in undernourished Wistar rats at 7, 14 and 21 days of age. The issue was addressed by analyzing the olfactory bulb (OB) cross sectional area, the total number and area of OGs in the OB coronal sections, and the distribution of OG area in dorsal and ventral quadrants. Reductions in the OB and OG cross sectional areas were detected at 7 and 14 days posnatally. OG area comparisons by OB quadrants were reduced along the study in quadrants, with larger effects in medial than in lateral OB quadrants. Current OG cytoarchitectonic modifications may affect the newborn capabilities for odour discrimination by disrupting early mother-litter interactions.

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Section: Physical Developmentsupporting

confidence: 87%

“…These morphological alterations are commonly associated with delayed physical growth and behavioural and electrophysiological abnormalities that impair odour discrimination and long-term social olfactory-guided behavioural performance (Math and Davrainville 1980, Meisami and Safari 1981, Almli et al 1985, Bedi 1992.…”

Section: Introductionmentioning

confidence: 99%

Organization of olfactory glomeruli in neonatally undernourished rats

Frías

Torrero

Regalado

et al. 2006

Nutritional Neuroscience

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show abstract

“…There is general agreement that the uptake of 2DG observed with the Sokoloff method is associated with sites of increased neuronal activity (Greer et al, 1981a;Schwartz et al, 1979;Mata et al, 1980). Our previous studies, as well as those of others, in the mammalian olfactory system support this interpretation (Sharp et al, 1977;Stewart et al, 1979;Jourdan et al, 1980;Greer et al, 1981a, b).…”

Section: Discussionsupporting

confidence: 74%

Functional development of the olfactory bulb and a unique glomerular complex in the neonatal rat

Greer¹,

Stewart²,

Mh³

et al. 1982

J. Neurosci.

139

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The ['4C]2-deoxy-D-glucose (2DG) technique was employed to study the ontogeny of functional organization in the olfactory bulbs of rats from birth to 21 days postnatal. These observations were correlated with the histological maturation of the olfactory bulb laminae. In O-day pups (within 12 hr of parturition), foci of increased metabolic activity were elicited in the olfactory bulb by the odor of amyl acetate. The foci, generally poorly defined, were localized over the glomerular layer, which, in histological sections, was poorly differentiated. In suckling pups injected with 2DG, a single focus characteristically was observed in the main olfactory bulb near the medial border of the accessory olfactory bulb. In this region, a well differentiated complex of glomeruli was observed in the histological sections.During the ensuing 21 days postnatal, the focal patterns of 2DG uptake in animals exposed to amyl acetate odor progressed through a series of changes, each of which could be related to parallel stages of development in the histology of the bulb. Particularly striking were the establishment of sharply defined 2DG foci and the formation of distinct individual olfactory glomeruli by the end of the 1st week. Generally, by 15 days postnatal, the adult patterns of 2DG uptake and histological lamination were established.The modified glomerular complex also exhibited focal 2DG uptake beginning on day 0, but these were better defined than those associated with the glomeruli of the main olfactory bulb. This observation correlated with the more advanced histological differentiation of this specialized region. These data suggest that the modified glomerular complex may mature earlier than other regions of the olfactory bulb. This earlier maturation may reflect the importance of the modified glomerular region for processing odor cues relevant to suckling behavior in neonatal rats.Taken together, these results provide evidence for several successive changes in the functional organization of the developing olfactory system of neonatal rats.The neural substrates of olfactory function in the neonatal rat are not well understood. Behavioral studies generally agree upon the critical role of olfaction during the perinatal period of development (Blass and Teicher,

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“…In the rat, perinatal undernutrition results in severe deficiencies of sensorial maturation as evidenced by retarded ear and eye opening, altered olfactory and auditory neural mechanisms to modulate the sensory input, and delayed somatosensory and visual electrophysiological maturation (Callison and Spencer, 1968;Salas and Cintra, 1973;Math and Davrainville, 1980;Pascual et al, 1993;Salas et al, 1994;Torrero et al, 1999;Pascual and Figueroa, 1996). Immuno and histochemical methods have shown that NSTc neurons are activated by different stressors, particularly the acute 30 min footshock stimulation; however, little is known about the effects of other stressors such as reduced milk components and dried oral mucous membrane cues associated with perinatal food restriction (Morales and Sawchenko, 2003).…”

Section: Introductionmentioning

confidence: 99%

Alterations in the Solitary Tract Nucleus of the Rat Following Perinatal Food Restriction and Subsequent Nutritional Rehabilitation

Rubio¹,

Torrero²,

Regalado³

et al. 2004

Nutritional Neuroscience

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Newborn of altricial species maintain functional gustatory communication with the mother because the neural substrate and the capacity to discriminate and promote gustofacial responses are already operating. Because little is known about the effects of perinatal food restriction upon gustatory neuronal brain stem structures, we characterized neuronal Golgi-Cox alterations of the solitary tract rostral portion (NSTr) where gustatory information is known to convey in neonatal Wistar rats. Pre-and neonatally undernourished rats exhibited a general reduction in the number and extension of distal dendrites particularly in small neurons but little effect upon perikarya measurements of the NSTr neuronal population. By contrast, in nutritional and sensory rehabilitated rats the number of distal dendrites increased, although the dendritic extensions were less affected compared to perinatally underfed and control subjects. The data indicate that perinatal food restriction interferes with the NSTr dendritic arbor organization, while nutritional and sensorial rehabilitation given by normally lactating dams induced plastic changes presumably modifying the integrative processes underlying early taste discriminative capabilities. Moreover, since perinatal food restriction is a powerful stressor influence and the NST forms a part of a complex system underlying adaptive stress responses, the neuronal alterations observed here may be partly due to this noxious perinatal influence.

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Electrophysiological study on the postnatal development of mitral cell activity in the rat olfactory bulb. Influence of undernutrition

Cited by 27 publications

References 11 publications

Organization of olfactory glomeruli in neonatally undernourished rats

Organization of olfactory glomeruli in neonatally undernourished rats

Functional development of the olfactory bulb and a unique glomerular complex in the neonatal rat

Alterations in the Solitary Tract Nucleus of the Rat Following Perinatal Food Restriction and Subsequent Nutritional Rehabilitation

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