Electrophysiological studies of Nephila clavata venom and toxin influence on hippocampal neuronal membranes after pretreatment with Aspergillus oryzae proteases
Abstract:Background. The use of Arthropodae toxins for electrophysiological experiments is very important, but experimental data in this regard are scarce. The aim of this study was to obtain experimental data about the influence of Nephila clavata spider venom and its main active component-toxin JSTX-3 on the glutamate channel-receptor complex. Methods. Kainate was used as agonist of glutamate channel-receptor complex because it initiated non-inactivated transmembrane electric currents in rat hippocampal membranes in … Show more
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