Electrophysiological Studies in Migraine: A Comprehensive Review of Their Interest and Limitations

Ambrosini, Anna; Noordhout, Alain Maertens De; Sándor, Péter; Schoenen, Jean

doi:10.1046/j.1468-2982.2003.00571.x

Cited by 144 publications

(158 citation statements)

References 144 publications

Supporting

Mentioning

145

Contrasting

Unclassified

Order By: Relevance

“…The phosphene threshold (PT) in migraine patients was found to be lower than in healthy volunteers in some studies, but similar or higher in others (reviewed in [94]). Some discrepancies could be due to methodological differences that may be device-and patient-dependent.…”

Section: Discussionmentioning

confidence: 71%

Electrophysiological response patterns of primary sensory cortices in migraine

Ambrosini

Schoenen

2006

J Headache Pain

View full text Add to dashboard Cite

Migraine is an ictal disorder characterised by a particular vulnerability of patients to sensory overload, both during and outside of the attack. Central nervous system dysfunctions are supposed to play a pivotal role in migraine. Electroneurophysiological methods, which aim to investigate sensory processing, seem thus particularly appropriate to study the pathophysiology of migraine. We have thus reviewed evoked potential studies performed in migraine patients. Although results are in part contradictory, these studies nonetheless demonstrate an interictal dysfunction of sensory cortices, and possibly of subcortical structures, in migraine with and without aura. The predominant abnormality is a deficient habituation of evoked responses to repeated stimuli, probably due to cortical, and possibly widespread neural, "dysexcitability".

show abstract

Section: Discussionmentioning

confidence: 71%

Electrophysiological response patterns of primary sensory cortices in migraine

Ambrosini

Schoenen

2006

J Headache Pain

View full text Add to dashboard Cite

show abstract

“…Our finding highlights the importance of taking the time to the next attack into account when investigating migraine patients. Just as the migraine cycle spans several days and contains up to five phases (prodromi, aura, headache, resolution, and recovery) (Blau, 1992), the trigeminal activity in migraine patients is not constant but strongly variable (Ambrosini et al, 2003;. Averaged imaging data point to hyporeactive trigeminal neurons during trigemino-nociceptive stimulation in migraine patients compared with controls.…”

Section: Discussionmentioning

confidence: 99%

Trigeminal Nociceptive Transmission in Migraineurs Predicts Migraine Attacks

Stankewitz¹,

Aderjan²,

Eippert³

et al. 2011

J. Neurosci.

242

212

View full text Add to dashboard Cite

Several lines of evidence suggest a major role of the trigeminovascular system in the pathogenesis of migraine. Using functional magnetic resonance imaging (fMRI), we compared brain responses during trigeminal pain processing in migraine patients with those of healthy control subjects. The main finding is that the activity of the spinal trigeminal nuclei in response to nociceptive stimulation showed a cycling behavior over the migraine interval. Although interictal (i.e., outside of attack) migraine patients revealed lower activations in the spinal trigeminal nuclei compared with controls, preictal (i.e., shortly before attack) patients showed activity similar to controls, which demonstrates that the trigeminal activation level increases over the pain-free migraine interval. Remarkably, the distance to the next headache attack was predictable by the height of the signal intensities in the spinal nuclei. Migraine patients scanned during the acute spontaneous migraine attack showed significantly lower signal intensities in the trigeminal nuclei compared with controls, demonstrating activity levels similar to interictal patients. Additionally we found-for the first time using fMRI-that migraineurs showed a significant increase in activation of dorsal parts of the pons, previously coined "migraine generator." Unlike the dorsal pons activation usually linked to migraine attacks, the gradient-like activity following nociceptive stimulation in the spinal trigeminal neurons likely reflects a raise in susceptibility of the brain to generate the next attack, as these areas increase their activity long before headache starts. This oscillating behavior may be a key player in the generation of migraine headache, whereas attack-specific pons activations are most likely a secondary event.

show abstract

“…The majority of studies on evoked and event-related potentials in migraine have shown two abnormalities: increased amplitudes of averages of large numbers of trials and lack of habituation in successive trial blocks during the pain-free phase, which seems to reverse to normal pattern for an homeostatic mechanism [1]. This pattern has suggested an abnormal state of cortical excitability during the interictal phase of migraine, which is reversed during the attack for a homeostatic mechanism [1].…”

Section: Introductionmentioning

confidence: 99%

Habituation of single CO2 laser–evoked responses during interictal phase of migraine

et al. 2005

View full text Add to dashboard Cite

A reduced habituation of averaged laser–evoked potential (LEP) amplitudes was previously found in migraine patients. The aim of the present study was to assess the habituation of single LEP responses and pain sensation during the interictal phase in migraine patients. Fourteen migraine patients were compared with ten control subjects. The pain stimulus was laser pulses, generated by CO 2 laser, delivered to right supraorbital zone. Patients were evaluated during attack–free conditions. The LEP habituation was studied by measuring the changes of LEP amplitudes across and within three consecutive repetitions of 21 non–averaged trials. In migraine patients the N2–P2 wave amplitudes did not show a tendency toward habituation across and, above all, within the three repetitions. Anomalous behaviour of nociceptive cortex during the interictal phase of migraine may predispose patients to headache occurrence and persistence.

show abstract

Electrophysiological Studies in Migraine: A Comprehensive Review of Their Interest and Limitations

Cited by 144 publications

References 144 publications

Electrophysiological response patterns of primary sensory cortices in migraine

Electrophysiological response patterns of primary sensory cortices in migraine

Trigeminal Nociceptive Transmission in Migraineurs Predicts Migraine Attacks

Habituation of single CO2 laser–evoked responses during interictal phase of migraine

Contact Info

Product

Resources

About