Electrophysiological Stimulation of Whole Heart Constructs in an 8‐Pole Electrical Field

Hülsmann, Jörn; Aubin, Hug; Sugimura, Yukiharu; Lichtenberg, Artur; Akhyari, Payam

doi:10.1111/aor.13322

Cited by 6 publications

(8 citation statements)

References 19 publications

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“…Combinations of both techniques have also been described . Whole‐heart recellularization in the rat model is commonly performed using rNCs and RAECs . Various research groups have observed electrical signalling and corresponding contraction in vitro , where recellularized hearts were maintained for up to 30 days .…”

Section: Heartmentioning

confidence: 99%

“…On the other hand, tissue engineering of the heart requires electrical and biomechanical stimulation, such as the system built by Hülsmann et al . . In the tissue engineering of organs such as the liver, monitoring of the levels of albumin and coagulation factors is of crucial importance.…”

Section: Bioreactors For De‐ and Recellularizationmentioning

confidence: 99%

“… describes a decellularization process through the venous and arterial system. Many recellularization and reendothelialization studies have been conducted since 2008 , with direct injection (multiple injections) into the ECM and the infusion of the endothelial cells via the coronary arteries or venous inlet (e.g. multistep infusion and recirculation) being the most commonly applied methods.…”

Section: Heartmentioning

confidence: 99%

“… used iPSC‐derived human cardiomyocytes (500 million) to repopulate the parenchyma. Moreover, the mechanical properties of the decellularized tissue have also been studied , and the beneficial effects of mechanical and electrical stimulation during in vitro maturation have been confirmed . Although de‐ and recellularized heart grafts have been heterotopically implanted in rat, porcine and bovine models for up to 60 days , none of these transplantation experiments showed in vivo functionality and long‐term perfusion of the implants.…”

Section: Heartmentioning

confidence: 99%

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Strategies based on organ decellularization and recellularization

et al. 2019

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Summary Transplantation is the only curative treatment option available for patients suffering from end‐stage organ failure, improving their quality of life and long‐term survival. However, because of organ scarcity, only a small number of these patients actually benefit from transplantation. Alternative treatment options are needed to address this problem. The technique of whole‐organ decellularization and recellularization has attracted increasing attention in the last decade. Decellularization includes the removal of all cellular components from an organ, while simultaneously preserving the micro and macro anatomy of the extracellular matrix. These bioscaffolds are subsequently repopulated with patient‐derived cells, thus constructing a personalized neo‐organ and ideally eliminating the need for immunosuppression. However, crucial problems have not yet been satisfyingly addressed and remain to be resolved, such as organ and cell sources. In this review, we focus on the actual state of organ de‐ and recellularization, as well as the problems and future challenges.

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Section: Heartmentioning

confidence: 99%

Section: Bioreactors For De‐ and Recellularizationmentioning

confidence: 99%

Section: Heartmentioning

confidence: 99%

Section: Heartmentioning

confidence: 99%

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Strategies based on organ decellularization and recellularization

et al. 2019

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“…The RCNN model is a promising decoder of EMG and the sensor fusion can increase the accuracy and robustness of the myoelectric control system. Jörn Hülsmann et al 86 of the Heinrich Heine University, Duesseldorf, Germany, reported on the impact of threedimensional electrophysiological (EP) stimulation of tissue-engineered whole heart constructs (WHC) in a custom made eight-pole electrical field stimulation system by short model cultivations with neonatal rat cardiomyocytes (CM). Strong reduction of voltage signals by the decellularized extracellular matrix (ECM) component of WHC was observed.…”

Section: Stimulation and Neuromuscular Supportmentioning

confidence: 99%

Artificial Organs 2018: A Year in Review

Malchesky¹

2019

Artificial Organs

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In this Editor's Review, articles published in 2018 are organized by category and summarized. We provide a brief reflection of the research and progress in artificial organs intended to advance and better human life while providing insight for continued application of these technologies and methods. Artificial Organs continues in the original mission of its founders “to foster communications in the field of artificial organs on an international level.” Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ Replacement, Recovery, and Regeneration from all over the world. Peer‐reviewed special issues this year included contributions from the 13th International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion edited by Dr. Akif Undar, and the 25th Congress of the International Society for Mechanical Circulatory Support edited by Dr. Marvin Slepian. Additionally, many editorials highlighted the worldwide survival differences in hemodialysis and perspectives on mechanical circulatory support and stem cell therapies for cardiac support. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers the quality expected from such a journal could not be possible. We also express our special thanks to our Publisher, John Wiley & Sons for their expert attention and support in the production and marketing of Artificial Organs. We look forward to reporting further advances in the coming years.

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Recellularization of Decellularized Whole Organ Scaffolds: Elements, Progresses, and Challenges

Huang

Tan

et al. 2021

Decellularized Materials

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Electrophysiological Stimulation of Whole Heart Constructs in an 8‐Pole Electrical Field

Cited by 6 publications

References 19 publications

Strategies based on organ decellularization and recellularization

Strategies based on organ decellularization and recellularization

Artificial Organs 2018: A Year in Review

Recellularization of Decellularized Whole Organ Scaffolds: Elements, Progresses, and Challenges

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