Electrophysiological remodeling of linopirdine on neuroexcitability of myelinated A-type baroreceptor neurons in rats

Ban, Takahiko; Yu, Jun; Zhang, Yuyao; Cao, Panxiang; Liu, Sheng-Zhi; Wang, Xiaolong; Ba, Lina; Zhang, Tian-Ci; Guo, Xueyuan; Yu, Xue; Qiao, Guofu; Li, Bai‐Yan

doi:10.1016/j.ijcard.2014.03.033

Cited by 9 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mutations in these channels result in inherited epilepsy of newborns . The M‐current has also been identified as a modulator of arterial baroreceptor function . Mutations in KCNQ4 lead to congenital deafness without arrhythmia …”

Section: Kcnq Channels and Arterial Vascular Tonementioning

confidence: 99%

Perivascular adipose tissue and the dynamic regulation of K_v7 and K_ir channels: Implications for resistant hypertension

2018

View full text Add to dashboard Cite

potential for potassium ions; EPAC, exchange protein directly activated by cAMP; KCNQ channels, voltage-gated potassium channels encoded by KCNQ genes; K ir channels, inwardly rectifying potassium channels; K v channels, voltage-gated potassium channels; PVAT, perivascular adipose tissue; VSMC, vascular smooth muscle cell; XE991, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride.*Equal contribution as senior authors. AbstractResistant hypertension is defined as high blood pressure that remains uncontrolled despite treatment with at least three antihypertensive drugs at adequate doses.

show abstract

Section: Kcnq Channels and Arterial Vascular Tonementioning

confidence: 99%

Perivascular adipose tissue and the dynamic regulation of K_v7 and K_ir channels: Implications for resistant hypertension

2018

View full text Add to dashboard Cite

show abstract

“…The sex differences in neurocontrol of circulation at baroreflex level have almost been neglected although AT 1 R or AT 2 R has been identified in nodose ganglia (NG) or nucleus of tractus solitary (NTS). a female-specific subpopulation of low-threshold myelinated Ah-type baroreceptor neurons (BRNs), which presented not only in NG [13][14][15][16][17][18] but also in NTS. 19,20 Ah-type BRNs were rarely found in adult male rats and exhibited an excitability profile that was strongly influenced by circulating sex hormones 3,18,21 and neurotransmitters.…”

mentioning

confidence: 99%

Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation

Yang

Zhou

et al. 2016

Hypertension

Self Cite

View full text Add to dashboard Cite

T he sex difference in blood pressure (BP) has long been recognized between premenopausal women and agedmatched men.1 Women are protected from most cardiovascular events compared with age-matched men before menopause, and postmenopausal women are at increased risk of cardiovascular complications compared with premenopausal women. 2 The pathophysiological mechanisms have been extensively explored, and increasing evidences have shown that the female hormone is one of the major mechanisms contributing to the above phenomena.3 Several studies have demonstrated the importance of the interaction between sex hormones and the renin-angiotensin system in regulating cardiovascular function and BP. 4,5 Angiotensin-II (Ang-II) is a key player in the development of hypertension. Ang-II type-1 (AT 1 R) and type-2 (AT 2 R) receptors play opposite roles in BP regulation, 6,7 with AT 2 R exerting a cardioprotective action in essential hypertension. 8 Early study demonstrates that AT 2 R provides a major clue for solving the mystery of sex differences in AT 2 R-mediated vasodilation 9 and hypertension. 10 However, the majority of researches on hypertension to date has been conducted in male animals and focused largely on the target organs, such as the heart, blood vessels, and kidney. The sex differences in neurocontrol of circulation at baroreflex level have almost been neglected although AT 1 R or AT 2 R has been identified in nodose ganglia (NG) or nucleus of tractus solitary (NTS). 11,12 Recent literatures have shown that adult female rats express Abstract-This study aims to understand the special expression patterns of angiotensin-II receptor (AT 1 R and AT 2 R) in nodose ganglia and nucleus of tractus solitary of baroreflex afferent pathway and their contribution in sex difference of neurocontrol of blood pressure regulation. In this regard, action potentials were recorded in baroreceptor neurons (BRNs) using whole-cell patch techniques; mRNA and protein expression of AT 1 R and AT 2 R in nodose ganglia and nucleus of tractus solitary were evaluated using real time-polymerase chain reaction, Western blot, and immunohistochemistry at both tissue and single-cell levels. The in vivo effects of 17β-estradiol on blood pressure and AT 2 R expression were also tested. The data showed that AT 2 R, rather than AT 1 R, expression was higher in female than age-matched male rats. Moreover, AT 2 R was downregulated in ovariectomized rats, which was restored by the administration of 17β-estradiol. Single-cell real time-polymerase chain reaction data indicated that AT 2 R was uniquely expressed in Ah-type BRNs. Functional study showed that long-term administration of 17β-estradiol significantly alleviated the blood pressure increase in ovariectomized rats. Electrophysiological recordings showed that angiotensin-II treatment increased the neuroexcitability more in Ah-than C-type BRNs, whereas no such effect was observed in A-types. In addition, angiotensin-II treatment prolonged action potential duration, which was not further changed...

show abstract

“…In addition, differential reaction to extracellular Ca 2+ [11], pharmacological agent [12], and neurotransmitter [13] between myelinated and unmyelinated baroreceptor afferents for the above variation should also be taken into the consideration.…”

mentioning

confidence: 99%

Variations in afferent conduction and axonal morphometrics of aortic depressive nerve imply wider baroreflex function of low-threshold and sex-specific myelinated Ah-type baroreceptor neurons in rats

Yan

Wen

et al. 2015

International Journal of Cardiology

Self Cite

View full text Add to dashboard Cite

Electrophysiological remodeling of linopirdine on neuroexcitability of myelinated A-type baroreceptor neurons in rats

Cited by 9 publications

References 10 publications

Perivascular adipose tissue and the dynamic regulation of K_v7 and K_ir channels: Implications for resistant hypertension

Perivascular adipose tissue and the dynamic regulation of K_v7 and K_ir channels: Implications for resistant hypertension

Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation

Variations in afferent conduction and axonal morphometrics of aortic depressive nerve imply wider baroreflex function of low-threshold and sex-specific myelinated Ah-type baroreceptor neurons in rats

Contact Info

Product

Resources

About

Electrophysiological remodeling of linopirdine on neuroexcitability of myelinated A-type baroreceptor neurons in rats

Cited by 9 publications

References 10 publications

Perivascular adipose tissue and the dynamic regulation of Kv7 and Kir channels: Implications for resistant hypertension

Perivascular adipose tissue and the dynamic regulation of Kv7 and Kir channels: Implications for resistant hypertension

Unique Expression of Angiotensin Type-2 Receptor in Sex-Specific Distribution of Myelinated Ah-Type Baroreceptor Neuron Contributing to Sex-Dimorphic Neurocontrol of Circulation

Variations in afferent conduction and axonal morphometrics of aortic depressive nerve imply wider baroreflex function of low-threshold and sex-specific myelinated Ah-type baroreceptor neurons in rats

Contact Info

Product

Resources

About

Perivascular adipose tissue and the dynamic regulation of K_v7 and K_ir channels: Implications for resistant hypertension

Perivascular adipose tissue and the dynamic regulation of K_v7 and K_ir channels: Implications for resistant hypertension