“…The latter appears to be the predominant mechanism in several different types of mammalian central neurones (Lux, Loracher & Neher, 1970;Llinas, Baker & Precht, 1974;Raabe & Gumnit, 1975;Misgeld, Deisz, Dodt & Lux, 1986;Thompson, Deisz & Prince, 1988a, b;Thompson & Giihwiler, 1989) and in other neural preparations (Russel & Brown, 1972;Nicoll, 1978;Scappaticci, Dretchen, Carpenter & Pellmar, 1981;Aickin, Deisz & Lux, 1982;Altamirano & Russell, 1987). The outward movement of Cl-is considered to be coupled to K+ (Aickin et al 1982), but a HCO3--Cl-exchange cannot be excluded (Church & McLennan, 1989;Russell & Boron, 1990). If an outward transport system exists in these immature CAl neurones, activation of the outward Cl-transport will cause a net efflux of Cl-ions against the electro-chemical gradient, and move EGABA or EIPSP towards a more negative potential.…”