Electrophysiological investigation of the effectiveness of methylphenidate in children with and without ADHD

Seifert, Juergen; Scheuerpflug, P.; Zillessen, K.E; Fallgatter, Andreas J.; Warnke, Andreas

doi:10.1007/s00702-003-0818-8

Cited by 55 publications

(21 citation statements)

References 22 publications

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“…Importantly, the LPW finding cannot be attributed to the effect of acute stimulant medication: The ADHD children chronically treated were off stimulants at the time of testing. Although several ERP papers have reported acute effects of stimulant treatment (for reviews, see Klorman, 1991;Seifert, Scheuerpflug, Zillessen, Fallgatter, & Warnke, 2003), this is, to our knowledge, the first time that ERP effects of chronic stimulant treatment history have been identified.…”

Section: Lpw Effects: Previous Treatment Historymentioning

confidence: 86%

Electrophysiological correlates of response inhibition in children and adolescents with ADHD: Influence of gender, age, and previous treatment history

et al. 2007

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Deficits in response inhibition may be at the core of the cognitive syndrome in ADHD. Here, inhibitory control mechanisms were studied in 36 ADHD-combined type and 30 healthy children by exploring the event-related brain activity during the Stop Signal task. The influence of age, gender, and previous treatment history was evaluated. The ADHD group showed reduced N200 wave amplitudes. For successful inhibitions, the N200 reduction was greatest over right inferior frontal scalp, and only the control group showed a success-related enhancement of such right frontal N200. Source analysis identified a source of the N200 group effect in right dorsolateral prefrontal cortex. Finally, a late positive wave to failed inhibitions was selectively reduced only in treatment-naïve ADHD children, suggesting that chronic stimulants may normalize late conscious error recognition. Both effects were independent of gender and age.

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Section: Lpw Effects: Previous Treatment Historymentioning

confidence: 86%

Electrophysiological correlates of response inhibition in children and adolescents with ADHD: Influence of gender, age, and previous treatment history

et al. 2007

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“…Two reports about stimulus-locked data analysis in this sample have been published before [34], [35], however, these reports did not include any movement-related potential analyses. All subjects were right-handed according to the Edinburgh Handedness Inventory [37].…”

Section: Methodsmentioning

confidence: 99%

“…Subjects who were recorded off medication first, were naïve to stimulant medication. Subjects who were recorded on medication first withdrew the medication for one week before the second session [4], [34], [35]. All recordings took place at 9 am, which was one hour after medication intake during the on-medication session of the patient group.…”

Section: Methodsmentioning

confidence: 99%

“…Though no complete lateralized readiness potential could be calculated because no left hand button presses were available, previous studies have shown that lateralization of MRPs is much stronger for button presses with the dominant hand [40], [41]. We checked carefully in a comparison with stimulus-locked data [34], [35], that the time-course of our reported results differed from the time-course of any possible lateralization of the P300/late positive complex. P300 topography showed a left-lateralized positive maximum with the applied verbal (letter) task and led to a positive peak in P3–P4 (see Figure 1).…”

Section: Methodsmentioning

confidence: 99%

“…more or less concentrated states) and stimulant medication would differentially affect the neuronal activation related to triggering a movement (iMP) or its post-processing in short term motor memory (mPINV), we analysed lateralized MRP in a previously characterized sample of children with ADHD and matched controls [34], [35]. Based on the above mentioned literature, we hypothesized that children with ADHD would show less lateralized iMP potentials especially in trials with slow reaction times (lapses of attention).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Stimulant Medication and Response Speed on Lateralization of Movement-Related Potentials in Attention-Deficit/Hyperactivity Disorder

Bender¹,

Resch

Klein

et al. 2012

PLoS ONE

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Background Hyperactivity is one of the core symptoms in attention deficit hyperactivity disorder (ADHD). However, it remains unclear in which way the motor system itself and its development are affected by the disorder. Movement-related potentials (MRP) can separate different stages of movement execution, from the programming of a movement to motor post-processing and memory traces. Pre-movement MRP are absent or positive during early childhood and display a developmental increase of negativity. Methods We examined the influences of response-speed, an indicator of the level of attention, and stimulant medication on lateralized MRP in 16 children with combined type ADHD compared to 20 matched healthy controls. Results We detected a significantly diminished lateralisation of MRP over the pre-motor and primary motor cortex during movement execution (initial motor potential peak, iMP) in patients with ADHD. Fast reactions (indicating increased visuo-motor attention) led to increased lateralized negativity during movement execution only in healthy controls, while in children with ADHD faster reaction times were associated with more positive amplitudes. Even though stimulant medication had some effect on attenuating group differences in lateralized MRP, this effect was insufficient to normalize lateralized iMP amplitudes. Conclusions A reduced focal (lateralized) motor cortex activation during the command to muscle contraction points towards an immature motor system and a maturation delay of the (pre-) motor cortex in children with ADHD. A delayed maturation of the neuronal circuitry, which involves primary motor cortex, may contribute to ADHD pathophysiology.

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Psychostimulants

Pliszka

2012

Pharmacotherapy of Child and Adolescent Psychiatric Disorders

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Electrophysiological investigation of the effectiveness of methylphenidate in children with and without ADHD

Cited by 55 publications

References 22 publications

Electrophysiological correlates of response inhibition in children and adolescents with ADHD: Influence of gender, age, and previous treatment history

Electrophysiological correlates of response inhibition in children and adolescents with ADHD: Influence of gender, age, and previous treatment history

Influence of Stimulant Medication and Response Speed on Lateralization of Movement-Related Potentials in Attention-Deficit/Hyperactivity Disorder

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