Electrophysiological investigation of central, peripheral and autonomic nerve function in workers with long-term low-level exposure to carbon disulphide in the viscose industry

Reinhardt, Frank; Drexler, Hans; Bickel, Andreas; Claus, D.; Ulm, K.; Angerer, Jürgen; Lehnert, G.; Neundörfer, B.

doi:10.1007/s004200050215

Cited by 21 publications

(7 citation statements)

References 26 publications

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“…Age is often used as a covariate such as in the ARIC, FHS, and Whitehall studies. In those studies that have specifically investigated the relationship between age and cardiac function, consistent evidence supports this relationship [53]. For example Antelmi et al [52] investigated the association between age and vagal tone in 292 men and 361 women aged from 14 to 82 years.…”

Section: Non-modifiable Risk Factors: Age and Family Historymentioning

confidence: 92%

The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors

Thayer

Yamamoto

Brosschot

2010

International Journal of Cardiology

1,733

1,299

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Section: Non-modifiable Risk Factors: Age and Family Historymentioning

confidence: 92%

The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors

Thayer

Yamamoto

Brosschot

2010

International Journal of Cardiology

1,733

1,299

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“…These effects have been observed in workers exposed to CS2 at 1.0 ppm or above. In contrast, other studies on viscose rayon workers exposed to equal concentrations of CS2 have shown little indication of an effect on NCV 11,14 ) . Furthermore, NCV in the present CS2 exposed group was lower than that removed from the CS2 exposure group on a cross-sectional observation 9) .…”

Section: Introductionmentioning

confidence: 89%

“…Toxicity is most often manifested as slower nerve conduction velocity (NCV) in the peripheral nerves 1,7 ) and impaired performance in psychomotor testing 8) . Peripheral nervous system effects have been reported in many cross-sectional studies on workers exposed to CS2 in the viscose rayon industry 1,7,[9][10][11][12][13]14) . The most common observations are characterized by slower motor (MCV) and sensory nerve conduction velocity (SCV) 1,7,9,15) .…”

Section: Introductionmentioning

confidence: 99%

Changes of median nerve conduction velocity in rayon manufacturing workers: A 6-year cohort study

Yoshioka¹,

Takebayashi²,

Nishiwaki³

et al. 2017

Journal of Occupational Health

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Objectives:We conducted a 6-year cohort study to evaluate the relationship between carbon disulfide (CS2) exposure and reductions in the motor and sensory nerve conduction velocity (MCV and SCV) of the median nerve. Methods : Study subjects at baseline included 432 exposed workers and 402 unexposed workers. Among the exposed workers, 145 workers terminated CS2 exposure during the followup period ( ex-exposed workers ) . MCV and SCV were measured at baseline and followed up. CS 2 personal exposure concentration was measured two times a year during a 6-year follow-up period and mean (range) CS2 exposure concentrations ( ppm ) were 5.96 (0.8-16.0) and 3.93 (0.6-9.9) in the exposed and ex-exposed workers, respectively. Results: Reductions in MCV during the follow-up period did not differ among the exposed, ex-exposed, and unexposed workers. Reduction in SCV (m/s) of the exposed workers (-4.47±3.94) was significantly larger than that of the unexposed (-3.38±3.97) and ex-exposed workers (-3.26±3.79). For SCV reduction, a partial multiple regression coefficient of (exexposed workers)/(unexposed workers) was significantly positive (+0.915, p < 0.01) after adjustment for confounding variables. Conclusions : This cohort study showed that 6-year CS 2 exposure around a mean level of 6 ppm did not affect MCV reduction but induced significant SCV reduction beyond the influence of aging. The effect of CS2 on SCV around a mean exposure level of 4 ppm may be reversible, since it disappeared in the ex-exposed workers after CS 2 exposure cessation for a mean period of 4.1

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“… Hazardous substances Neurotoxic substances can lead to a reduction in the HRV: e.g. carbon disulphide [ 169 , 170 ], however, not in the case of long-term low-dose exposure [ 171 ]; acute diesel and biodiesel inhalation [ 172 ]; chronic lead [ 173 , 174 ], acute cadmium [ 175 ] or long-term mercury exposures [ 176 ] and neurotoxic styrene exposure [ 177 , 178 ]. The data regarding the effects of chronic solvent exposure is not conclusive, both - a fall in the HRV and no differences - have been described [ 179 – 181 ].…”

Section: Determination Of the Nn Intervals For The Calculation Of Hr ...mentioning

confidence: 99%

Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science

Sammito,

Thielmann,

Klussmann

et al. 2024

J Occup Med Toxicol

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This updated guideline replaces the “Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science” first published in 2014. Based on the older version of the guideline, the authors have reviewed and evaluated the findings on the use of heart rate (HR) and heart rate variability (HRV) that have been published in the meantime and incorporated them into a new version of this guideline.This guideline was developed for application in clinical practice and research purposes in the fields of occupational medicine and occupational science to complement evaluation procedures with respect to exposure and risk assessment at the workplace by the use of objective physiological workload indicators. In addition, HRV is also suitable for assessing the state of health and for monitoring the progress of illnesses and preventive medical measures. It gives an overview of factors influencing the regulation of the HR and HRV at rest and during work. It further illustrates methods for measuring and analyzing these parameters under standardized laboratory and real workload conditions, areas of application as well as the quality control procedures to be followed during the recording and evaluation of HR and HRV.

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Electrophysiological investigation of central, peripheral and autonomic nerve function in workers with long-term low-level exposure to carbon disulphide in the viscose industry

Cited by 21 publications

References 26 publications

The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors

The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors

Changes of median nerve conduction velocity in rayon manufacturing workers: A 6-year cohort study

Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science

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