“…The N95 component displays spatial tuning and is considered a contrast-related component originating in the retinal ganglion cells (Berninger and Schuurmans, 1985;Hess and Baker, 1984;Korth, 1983;Luo and Frishman, 2011;Viswanathan et al, 2000), whereas the P50 is partly derived from ganglion cells but also has an additional luminance component that is believed to arise in the outer retina (Korth, 1983;Luo and Frishman, 2011;Trick and Wintermeyer, 1982). Reduced P50 and/or N95 amplitude and delays in timing of these major components of the transient pattern ERG have been reported in patients with early glaucoma (Hood et al, 2005;Marx et al, 1987;Parisi, 2001;Parisi et al, 2006). To investigate whether similar deficits are present in people with migraine, we adopted the ISCEV standard approach to measure the transient pattern ERG (1 Hz, 0.8 checks, 31 field, high contrast > 95%) in a group of 45 migraine sufferers (26 MO, 19 MA) and 30 nonheadache controls.…”