Electrophysiological evidence for altered early cerebral somatosensory signal processing in schizophrenia

Waberski, Till Dino; Norra, Christine; Kawohl, Wolfram; Thyerlei, Dinah; Hock, Dorothee; Klostermann, Fabian; Curio, Gabriel; Büchner, Helmut; Hoff, Paul; Gobbelé, René

doi:10.1111/1469-8986.2004.00163.x

Cited by 23 publications

(17 citation statements)

References 47 publications

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“…Although the optimal solution to model all the different early SEPs needs a complex source configuration with at least three dipoles (Buchner et al, 1995), for our aim to demonstrate differences in signal composition between the subgroups an approach with one dipole was considered to be sufficient. This is in accordance with other studies such as Norra et al (2004) or Waberski et al (2004). The resulting dipole waveform was digitally filtered.…”

Section: Methodssupporting

confidence: 94%

Early somatosensory processing in individuals at risk for developing psychoses

Hagenmuller

Theodoridou

Walitza

et al. 2014

Front. Behav. Neurosci.

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Human cortical somatosensory evoked potentials (SEPs) allow an accurate investigation of thalamocortical and early cortical processing. SEPs reveal a burst of superimposed early (N20) high-frequency oscillations around 600 Hz. Previous studies reported alterations of SEPs in patients with schizophrenia. This study addresses the question whether those alterations are also observable in populations at risk for developing schizophrenia or bipolar disorders. To our knowledge to date, this is the first study investigating SEPs in a population at risk for developing psychoses. Median nerve SEPs were investigated using multichannel EEG in individuals at risk for developing bipolar disorders (n = 25), individuals with high-risk status (n = 59) and ultra-high-risk status for schizophrenia (n = 73) and a gender and age-matched control group (n = 45). Strengths and latencies of low- and high-frequency components as estimated by dipole source analysis were compared between groups. Low- and high-frequency source activity was reduced in both groups at risk for schizophrenia, in comparison to the group at risk for bipolar disorders. HFO amplitudes were also significant reduced in subjects with high-risk status for schizophrenia compared to healthy controls. These differences were accentuated among cannabis non-users. Reduced N20 source strengths were related to higher positive symptom load. These results suggest that the risk for schizophrenia, in contrast to bipolar disorders, may involve an impairment of early cerebral somatosensory processing. Neurophysiologic alterations in schizophrenia precede the onset of initial psychotic episode and may serve as indicator of vulnerability for developing schizophrenia.

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Section: Methodssupporting

confidence: 94%

Early somatosensory processing in individuals at risk for developing psychoses

Hagenmuller

Theodoridou

Walitza

et al. 2014

Front. Behav. Neurosci.

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“…Early high-frequency oscillations were absent in schizophrenia [51] , and the higher amplitude in the low-frequency range showed a markedly inverse correlation to formal thought disorders and delusions [52] . Hence, delusional processing may also be caused by dysfunctional mechanisms of filtering and inhibition of irrelevant stimuli at the thalamic level before reaching the neocortex.…”

Section: Findings Of Imaging and Neurophysiological Studiesmentioning

confidence: 91%

Theories of Delusional Disorders

2007

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Delusional syndromes can occur in a number of psychiatric, neurological or other disorders. They can also be caused by neurotoxic agents (e.g., heavy metals) as well as substance addiction. There are several hypotheses on the underlying cognitive or emotional processes associated with organic factors of delusional disorders, depending on the patient groups examined and the methods used. The aim of this paper is to provide a comprehensive review and critical assessment of the various, rather heterogeneous theories in this field.

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“…These studies do not, however, exclude that magnocellular-like deficits could be generated pre-cortically. Interestingly, somatosensory impairments in schizophrenia, observed within 20 ms of target presentation, are interpreted in terms of a thalamic dysfunction which interferes with the flow of information from sensory input to cortex (Waberski, et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Psychophysical assessment of magno- and parvocellular function in schizophrenia

Delord¹,

Ducato

Pins

et al. 2006

Vis Neurosci

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Recently developed psychophysical techniques permit the biasing of the processing of the stimulus by early visual channels so that responses reflect characteristics of either magno- or parvocellular pathways (Pokorny & Smith, 1997). We used such techniques to test psychophysically whether the global magnocellular dysfunction reported in schizophrenia also affects early processes. Seven schizophrenic patients and 19 normal controls participated. The task was a four-alternative forced-choice luminance discrimination, using a 2 × 2 configuration of four 1-deg squares. Target luminance threshold was determined in three conditions: the stimulus, including the target, was pulsed for 17 ms (pulse paradigm); the target was presented on a steady background of four squares (steady paradigm), or the target was presented alone (no background paradigm). We replicated previous results demonstrating magnocellular and parvocellular signatures in control participants. No evidence for an early magnocellular deficit could be detected as the thresholds of all schizophrenic observers were higher both in the steady paradigm (presumed magnocellular mediation) and in the pulse paradigm (presumed parvocellular mediation). Magnocellular dysfunction, if present in schizophrenia, must concern more integrated processes, possibly at levels at which parvocellular and magnocellular paths interact.

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Electrophysiological evidence for altered early cerebral somatosensory signal processing in schizophrenia

Cited by 23 publications

References 47 publications

Early somatosensory processing in individuals at risk for developing psychoses

Early somatosensory processing in individuals at risk for developing psychoses

Theories of Delusional Disorders

Psychophysical assessment of magno- and parvocellular function in schizophrenia

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