1973
DOI: 10.2170/jjphysiol.23.81
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Electrophysiological Comparison of the Action of Oxytocin and Carbachol on Pregnant Mouse Myometrium

Abstract: Summary Effects of oxytocin and carbachol on the membrane potential, membrane conductance, and spike potential of pregnant mouse myometrium were investigated in isotonic and hypertonic solutions. 1) In an isotonic solution low concentrations of oxytocin (10-6-10-5 U/ml) did not cause any change in the membrane potential or in the amplitude of the action potential, but facilitated the conduction of excitation. With these concentrations, spontaneous contractions of truncated pattern became full-size. 2) Intermed… Show more

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Cited by 17 publications
(12 citation statements)
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“…About 10-5 to 10-4 g/ml of carbachol, the value varying by tissues , was needed to cause peak depolarization of about -20 mV. With this dose, the muscle strip undergoes sustained contracture (OsA and TAGA, 1973). It was found in the present experiment that the circular strip was more insensitive to carbachol .…”
Section: Resultsmentioning
confidence: 47%
“…About 10-5 to 10-4 g/ml of carbachol, the value varying by tissues , was needed to cause peak depolarization of about -20 mV. With this dose, the muscle strip undergoes sustained contracture (OsA and TAGA, 1973). It was found in the present experiment that the circular strip was more insensitive to carbachol .…”
Section: Resultsmentioning
confidence: 47%
“…Krnjevi6' (1974) has suggested a unifying hypothesis, applicable to all these cells, of a reduction in outward K current which has the dual effect of delaying repolarization following a spike and reducing the potential in the interspike interval. Certainly the actions of acetylcholine on ileum and on neurones are superficially very similar, but acetylcholine produces a large increase in conductance in smooth muscle (Bolton, 1972b;Magaribuchi, Ito & Kuriyama, 1973;Osa & Taga, 1973;Biilbring & Szurszewski, 1974) while it reduces the conductance of neuronal membrane (loc. cit.).…”
Section: Voltage Clamp Of Smooth Muscle 195mentioning
confidence: 99%
“…Thus, a spike may arise in a remote or deep part of the muscle (Osa & Taga, 1973) but, upon propagating to the region of recording its duration is greatly increased and its size reduced by the increased conductance. An argument against this 176 T.B.BOLTON VOLTAGE CLAMP OF SMOOTH MUSCLE hypothesis is that normal spikes can sometimes be recorded as taking off at the peak of the slow wave ( fig.…”
Section: Introductionmentioning
confidence: 99%
“…Studies of the rat, rabbit and mouse isolated myometrium demonstrate that, at low concentrations, oxytocin has the following properties [10,12,22,25] At high oxytocin concentrations, large intracellular depolarizations may occur [22] which could lead to suppression or block of spikes, whereas contractile tone remains elevated [4,5,18]. Furthermore, there are reports that at these high oxytocin concentrations, electrical and mechanical activity are no longer correlated, at least at the intracellular level [24].…”
Section: Introductionmentioning
confidence: 99%