Electrophysiological changes in auditory evoked potentials in rats with salicylate-induced tinnitus

Castañeda, Rodrigo; Natarajan, Sathishkumar; Jeong, Seo Yule; Hong, Bin Na; Kang, Tong Ho

doi:10.1016/j.brainres.2019.04.004

Cited by 7 publications

(30 citation statements)

References 48 publications

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“…In agreement with that, salicylate administration and acoustic trauma were found to reduce the ABR amplitude in experimental rats [27]. Nevertheless, the reduced amplitude could also reflect both signal reduction and desynchronization [28]. Therefore, the remaining necessary effort is to determine the ABR features that would indicate the presence of tinnitus independent of hearing loss.…”

Section: Introductionsupporting

confidence: 80%

“…For the induction of tinnitus, three methods were used (Figure 3). In 14 articles, tinnitus was induced with salicylate [13,[27][28][29][49][50][51][52][53][58][59][60]66]. Nineteen reports analyzed tinnitus after noise exposure [15,44,45,[54][55][56][57][61][62][63][64][65][67][68][69][70][71] and three analyzed tinnitus after blast injury [46][47][48].…”

Section: Methods Used For Tinnitus Inductionmentioning

confidence: 99%

“…In the articles selected for this review, Sprague-Dawley rats (both genders) were used in seventeen studies [13,28,[44][45][46][47][48][49][50][51][52][53][54][55][56][57]. Wistar rats were used in thirteen [15,27,29,[58][59][60][61][62][63][64][65], Long-Evans rats were used in four [66][67][68][69], and Fischer rats (FBN) were used in three studies [49,70,71].…”

Section: Strain Gender and Agementioning

confidence: 99%

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Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Domarecka

Szczepek

2020

Brain Sciences

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Tinnitus is a subjective phantom sound perceived only by the affected person and a symptom of various auditory and non-auditory conditions. The majority of methods used in clinical and basic research for tinnitus diagnosis are subjective. To better understand tinnitus-associated changes in the auditory system, an objective technique measuring auditory sensitivity—the auditory brainstem responses (ABR)—has been suggested. Therefore, the present review aimed to summarize ABR’s features in a rat model during experimentally induced tinnitus. PubMed, Web of Science, Science Direct, and Scopus databanks were searched using Medical Subject Heading (MeSH) terms: auditory brainstem response, tinnitus, rat. The search identified 344 articles, and 36 of them were selected for the full-text analyses. The experimental protocols and results were evaluated, and the gained knowledge was synthesized. A high level of heterogeneity between the studies was found regarding all assessed areas. The most consistent finding of all studies was a reduction in the ABR wave I amplitude following exposure to noise and salicylate. Simultaneously, animals with salicylate-induced but not noise-induced tinnitus had an increased amplitude of wave IV. Furthermore, the present study identified a need to develop a consensus experimental ABR protocol applied in future tinnitus studies using the rat model.

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Section: Introductionsupporting

confidence: 80%

Section: Methods Used For Tinnitus Inductionmentioning

confidence: 99%

Section: Strain Gender and Agementioning

confidence: 99%

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Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Domarecka

Szczepek

2020

Brain Sciences

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“…AEPs are electric potentials generated by the synchronous firing of neighbouring neural populations in the brain, which are time-locked responses to the specific acoustic stimulation 53 . Small-voltage signal deflections are considered to reflect physiological changes in the auditory pathway and the electrical potentials have been reported to have great sensitivity in revealing the functional integrity of the brain 54 . AEPs are widely used in clinical practice given their high temporal resolution and their ability to determine neural generators of the electrical responses.…”

Section: Discussionmentioning

confidence: 99%

Quantification of stroke lesion volume using epidural EEG in a cerebral ischaemic rat model

Yoo

Ham

Duc

et al. 2021

Sci Rep

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Precise monitoring of the brain after a stroke is essential for clinical decision making. Due to the non-invasive nature and high temporal resolution of electroencephalography (EEG), it is widely used to evaluate real-time cortical activity. In this study, we investigated the stroke-related EEG biomarkers and developed a predictive model for quantifying the structural brain damage in a focal cerebral ischaemic rat model. We enrolled 31 male Sprague–Dawley rats and randomly assigned them to mild stroke, moderate stroke, severe stroke, and control groups. We induced photothrombotic stroke targeting the right auditory cortex. We then acquired EEG signal responses to sound stimuli (frequency linearly increasing from 8 to 12 kHz with 750 ms duration). Power spectral analysis revealed a significant correlation of the relative powers of alpha, theta, delta, delta/alpha ratio, and (delta + theta)/(alpha + beta) ratio with the stroke lesion volume. The auditory evoked potential analysis revealed a significant association of amplitude and latency with stroke lesion volume. Finally, we developed a multiple regression model combining EEG predictors for quantifying the ischaemic lesion (R2 = 0.938, p value < 0.001). These findings demonstrate the potential application of EEG as a valid modality for monitoring the brain after a stroke.

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“…When bias due to the skill and the experience of the interpretators is involved, the variation is not trivial, especially for cases with untypical waveform or high background noise (Vidler and Parkert, 2004). As precise and objective measurement of small hearing threshold elevation became critical for diagnosis of progressive hearing loss (Barreira-Nielsen et al, 2016), hidden hearing loss (Kujawa and Liberman, 2009; Mehraei et al, 2016; Ridley et al, 2018; Sergeyenko et al, 2013), age-related hearing loss (Gates and Mills, 2005; Sergeyenko et al, 2013) and tinnitus (Bramhall et al, 2018; Castaneda et al, 2019), automated approaches with high precision and reliability are in demand to objectify the ABR threshold determination. Over decades, many attempts were made including: (1) quantification of the waveform similarity by comparison to existing templates (Davey et al, 2007; Elberling, 1979; Valderrama et al, 2014) as well as based on features learned by artificial neural network (Alpsan and Ozdamar, 1991; McKearney and MacKinnon, 2019) from human annotated datasets; (2) quantification of the waveform stability by cross-correlation function between single-sweeps (Bershad and Rockmore, 1974; Weber and Fletcher, 1980), interleaved responses (Berninger et al, 2014; Xu et al, 1995) or responses at adjacent stimulus levels (Suthakar and Liberman, 2019); (3) the ‘signal quality’ through scoring procedures like F-ratios (Cebulla et al, 2000; Don and Elberling, 1994; Elberling and Don, 1984; Sininger, 1993).…”

Section: Introductionmentioning

confidence: 99%

Real-time Hearing Threshold Determination of Auditory Brainstem Responses by Cross-correlation Analysis

Wang

Ding

et al. 2019

Preprint

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Auditory brainstem response (ABR) is widely employed to evaluate the hearing function, both in clinics and basic research. Despite many attempts for automation over decades, reliable determination of threshold stimulus level still relies on human visual identification of waveform, which oftentimes is subjective. Here, we report a robust procedure for automatic and accurate threshold determination in both mouse and human ABR. Contrary to prior approaches, in our new threshold determination algorithm, the on-going averaging is stopped once the waveform is confirmed by a cross-correlation time shift approach. The flexible ending sweep numbers for different stimuli is used to inform the threshold determination. We found a good match of the threshold readings between the algorithm and the human judges. Moreover, in the algorithm, smaller sweep number is required for strong response from supra-threshold level, and thus a considerable portion of sweeps can be saved in comparison to the case with level averaging of a fix number. These features are attractive and implementation of this method in commercial devices will make the ABR test procedure more objective and efficient.

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Electrophysiological changes in auditory evoked potentials in rats with salicylate-induced tinnitus

Cited by 7 publications

References 48 publications

Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review

Quantification of stroke lesion volume using epidural EEG in a cerebral ischaemic rat model

Real-time Hearing Threshold Determination of Auditory Brainstem Responses by Cross-correlation Analysis

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