Electrophysiological biomarkers of diagnosis and outcome in neurodevelopmental disorders

Jeste, Shafali; Frohlich, Joel; Loo, Sandra K.

doi:10.1097/wco.0000000000000181

Cited by 139 publications

(114 citation statements)

References 59 publications

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“…The researchers claimed this biomarker reflected that a disrupted reward-based interactional eye fixation regulatory system was the core ASD brain impairment (Klin et al 2015). ReebSutherland and Fox (2015), however, suggested that atypical eyeblink conditioning was a possible single ASD biomarker, and Jeste et al (2015) proposed that EEG patterns might be a possible biomarker for ASD. Small and Pelphrey (2015) proposed, BInnate olfactory behaviors may provide a link between early emerging sensory motor behaviors and the social deficits that characterize ASD( p. R675).…”

Section: Do Shared Features Provide Construct Validity For An Asd Spementioning

confidence: 99%

ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

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ASD research is at an important crossroads. The ASD diagnosis is important for assigning a child to early behavioral intervention and explaining a child's condition. But ASD research has not provided a diagnosis-specific medical treatment, or a consistent early predictor, or a unified life course. If the ASD diagnosis also lacks biological and construct validity, a shift away from studying ASD-defined samples would be warranted. Consequently, this paper reviews recent findings for the neurobiological validity of ASD, the construct validity of ASD diagnostic criteria, and the construct validity of ASD spectrum features. The findings reviewed indicate that the ASD diagnosis lacks biological and construct validity. The paper concludes with proposals for research going forward.Keywords DSM-5 . ASD . Autism . Diagnosis . Validity . Comorbidity . HeterogeneityThe goal of the DSM-3 nosology (American Psychiatric Association 1980) was to create reliable and standard categorical psychiatric diagnoses (Robins and Guze 1970). However, in the past 30 years, clinical, genetics, and neuroscience findings have revealed that the DSM diagnoses are not biologically valid. The National Institutes of Mental Health (NIMH) responded by proposing the Research Domain Criteria (RDoC) framework for a brain-based transdiagnostic psychiatric symptom nosology (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016). Peterson (2015) and Weinberger et al. (2015) argued that the RDoC could not replace the DSM-5 psychiatric nosology (American Psychiatric Association 2013) or the parallel International Classification of Diseases (ICD) psychiatric nosology (World Health Organization 2012). But BFor the foreseeable future, RDoC is not envisioned as a system of psychiatric classification in its own right. Instead, in the near term, RDoC and DSM-ICD are expected to coexist. Nevertheless, RDoC is intended to provide scaffolding for a large-scale research program that will ultimately yield an alternative to DSM-ICD^ (Lilienfeld and Treadway 2016, p. 445).RDoC advocates accept that DSM-5/ICD psychiatric categories remain necessary in clinical practice, but argue that researchers should shift to RDoC study designs immediately. They assert that studying psychiatric categories lacking biological validity blocks the discovery of brain bases for psychopathology and thus cannot lead to effective medical treatments for specific psychiatric symptoms (Cuthbert and Insel 2013;Insel et al. 2010;Lilienfeld and Treadway 2016;Yee et al. 2015). Against this RDoC imperative for biological validity, Weinberger et al. (2015) countered that current DSM-5 psychiatric behavioral diagnoses were valid when they yielded effective medical treatment, clear prognosis, and a life course specific to a diagnosis.Autism spectrum disorder (ASD) research has been productive (Dawson 2016;de la Torre-Ubieta et al. 2016;Szatmari et al. 2016), but no ASD research findings have met the validity criteria of Weinberger et al. (2015). DSM-5 ASD research has found no s...

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Section: Do Shared Features Provide Construct Validity For An Asd Spementioning

confidence: 99%

ASD Validity

Waterhouse

London

Gillberg

2016

Rev J Autism Dev Disord

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“…Furthermore, EEG topography helped to reintroduce EEG by means of theta cordance as a diagnostic marker for depression [9] and as a personalized treatment-response biomarker for antidepressants [10,11]. EEG has also become important as a research and clinical tool in the diagnosis and treatment of developmental disorders such as attention deficit hyperactivity disorder [12] and for monitoring the functional (cognitive) decline in Alzheimer's disease (AD), also being both a preclinical and clinical functional readout of brain substrates such as loss of synaptic plasticity and impaired neuronal connectivity [13,14,15]. …”

Section: Introductionmentioning

confidence: 99%

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Drinkenburg

Ruigt²,

Ahnaou

2015

Neuropsychobiology

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The contemporary value of animal pharmaco-electroencephalography (p-EEG)-based applications are strongly interlinked with progress in recording and neuroscience analysis methodology. While p-EEG in humans and animals has been shown to be closely related in terms of underlying neuronal substrates, both translational and back-translational approaches are being used to address extrapolation issues and optimize the translational validity of preclinical animal p-EEG paradigms and data. Present applications build further on animal p-EEG and pharmaco-sleep EEG findings, but also on stimulation protocols, more specifically pharmaco-event-related potentials. Pharmaceutical research into novel treatments for neurological and psychiatric diseases has employed an increasing number of pharmacological as well as transgenic models to assess the potential therapeutic involvement of different neurochemical systems and novel drug targets as well as underlying neuronal connectivity and synaptic function. Consequently, p-EEG studies, now also readily applied in modeled animals, continue to have an important role in drug discovery and development, with progressively more emphasis on its potential as a central readout for target engagement and as a (translational) functional marker of neuronal circuit processes underlying normal and pathological brain functioning. In a similar vein as was done for human p-EEG studies, the contribution of animal p-EEG studies can further benefit by adherence to guidelines for methodological standardization, which are presently under construction by the International Pharmaco-EEG Society (IPEG).

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“…From a basic science perspective, evidence about the state of readiness of the human newborn's brain has been central to issues in the nature-nurture debate [1,2]. From an educational perspective, data on the developmental state of the human brain over the early years is relevant for debates such as the effects of being raised within low social-economic status households [3], understanding ways to level the cognitive disparities at school entry, and early diagnosis and intervention for infants atrisk for later atypical outcomes such as Autism Spectrum Disorders (ASD) [1] or attention deficit/hyperactivity disorder (ADHD) [4] (see Box 1 for the abbreviations used throughout this review). The increasing knowledge on the relationship between structure and function shows the importance of the environment during early development [5 ], and therefore the significance of high quality early education.…”

Section: Introductionmentioning

confidence: 99%

Human brain development over the early years

Haartsen

Jones

Johnson

2016

Current Opinion in Behavioral Sciences

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Recent studies of the structural and functional development of the human brain over the early years have highlighted the rapid development of brain structures and their interconnectivity. Some regional functional specializations emerge within the first months after birth, while others have a more protracted course of development spanning over the first decade or longer. While some anatomical changes enable the emergence of new functions, evidence also points to the importance of resting state oscillations in sculpting neural architecture during development. In atypical development differences in brain structure, function and task-related activity in infancy often precede the emergence of later diagnostic behavioural symptoms.

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Electrophysiological biomarkers of diagnosis and outcome in neurodevelopmental disorders

Cited by 139 publications

References 59 publications

ASD Validity

ASD Validity

Pharmaco-EEG Studies in Animals: An Overview of Contemporary Translational Applications

Human brain development over the early years

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