Electrophysiological Basis of Atrial Fibrillation

Verheule, Sander; Brakel, Thomas van; Harks, Erik; Greiser, Maura; Allessie, Maurits A.

doi:10.1002/9780470696354.ch5

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Mechanisms Of Atrial Fibrillation2

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2014

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“…The onset and maintenance of the arrhythmia require both an initiating trigger and an anatomical substrate . The triggers are ectopic foci or reentrant waves . Substrates that favor and maintain AF are abnormalities in the atrium‐like atrial dilatation, inflammation, or fibrosis .…”

Section: Mechanisms Of Atrial Fibrillationmentioning

confidence: 99%

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Diagnosis and Management of Atrial Fibrillation: An Overview

Romero

Nedios

Kriatselis

2014

Cardiovascular Therapeutics

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Summary Atrial fibrillation (AF) has been defined as the new cardiovascular “epidemic”. Its prevalence is rising in developed countries, and the associated social and economic costs are high. In the last few years, there has been an increasing interest in understanding the mechanisms of AF and its management. New pharmacotherapies together with novel techniques for surgical and catheter treatment of AF have been developed, allowing the maintenance of sinus rhythm and the alleviation of symptoms in a large number of patients with AF. However, there are still some challenges that need to be addressed. This article gives an overview of the current state of the art on novel techniques for diagnosis and management of AF.

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Section: Mechanisms Of Atrial Fibrillationmentioning

confidence: 99%

“…The role of potassium currents is not known . Next to the electrical component (resulting from electrical remodeling), structural remodeling (e.g., atrial fibrosis) can result in more heterogeneous conduction that contributes to the onset of AF .…”

Section: Mechanisms Of Atrial Fibrillationmentioning

confidence: 99%