Electrophysiological assessment of visual pathway function in infants

Kriss, A.; Russell‐Eggitt, Isabelle

doi:10.1038/eye.1992.30

Cited by 60 publications

(43 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4,5,[32][33][34] Although reports of ERGs in ONH are few, they agree that flash ERGs are normal in the majority of cases. [17][18][19][20][21]34,35 However, normal ERGs are not universal and a variety of ERG abnormalities have been reported in ONH. Subnormal b-wave amplitude is reported in up to one-third of eyes and, in a few cases, ONH has been associated with absent scotopic b-waves, suggesting retinal dysfunction similar to that in congenital stationary night blindness.…”

Section: Discussionmentioning

confidence: 99%

“…Both neuro-radiological studies and anthropomorphic measurements aid in establishing the diagnosis and prognosis for young infants with ONH. [9][10][11][12][13][14][15][16][17][18] Visual evoked potential (VEP) testing can give a functional measure of vision early in life. In ONH, the amplitude of VEPs to flash stimulation and the presence of VEPs to pattern stimulation are correlated with visual function.…”

Section: Introductionmentioning

confidence: 99%

“…In ONH, the amplitude of VEPs to flash stimulation and the presence of VEPs to pattern stimulation are correlated with visual function. 7,14,[17][18][19] Typically, ONH is characterized by normal full-field electroretinograms (ERGs) and abnormal VEPs. [16][17][18][19] The a-waves of flash ERGs are consistently reported as normal in ONH, but several authors have reported abnormalities in the b-wave.…”

Section: Introductionmentioning

confidence: 99%

“…7,14,[17][18][19] Typically, ONH is characterized by normal full-field electroretinograms (ERGs) and abnormal VEPs. [16][17][18][19] The a-waves of flash ERGs are consistently reported as normal in ONH, but several authors have reported abnormalities in the b-wave. 20,21 Under photopic conditions, the b-wave is generated by the postreceptoral ON and OFF pathways mediated by the depolarizing and hyperpolarizing bipolar cells of the retina, with no significant contribution from ganglion cells.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Retinal function in infants with optic nerve hypoplasia: electroretinograms to large patterns and photopic flash

McCulloch

Garcia-Filion

Boemel

et al. 2006

Eye

View full text Add to dashboard Cite

Aims Optic nerve hypoplasia (ONH), which is defined as a congenital deficiency of retinal ganglion cells, may also involve more distal layers of the retina. We investigated electrophysiological function of the retina in ONH using electroretinograms (ERGs). Methods ERGs were recorded from 48 subjects (3.5-35 months) with unilateral or bilateral ONH. Pattern reversal (41 checks) was presented under chloral hydrate sedation, using an optical system to correct a cycloplegic refraction. A photopic flash stimulus was also used. Fundus photographs were used to measure the disk diameter/disk macula ratio (DD/DM), and to document other clinical signs. Eyes were classified as moderate (0.15-0.3) or severe (o0.15) ONH, and those with DD/DM greater than 0.3 were used as reference eyes. Results Pattern ERG recording was completed in 89 eyes and was detectable in 80% of eyes with ONH (61/76 tested) and in all 13 reference eyes. Photopic flash ERGs were of good quality in all eyes. The severity of ONH correlates with the amplitude of the photopic flash b-waves and with the amplitude of the N95 component of the pattern ERG (Po0.01). However, the ERGs to large patterns were well preserved (43.5 lV) in 10 of 35 eyes with severe ONH. Tortuous retinal vessels in eyes with either moderate or severe ONH were associated with smaller amplitude photopic b-waves and markedly diminished or undetectable pattern ERGs. Conclusions This study supports the hypothesis that retinal dysfunction distal to the ganglion cells is common in ONH, but is not predictable on the basis of ONH severity alone. Additionally, tortuous retinal vessels in ONH may be a sign associated with retinal dysfunction.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Retinal function in infants with optic nerve hypoplasia: electroretinograms to large patterns and photopic flash

McCulloch

Garcia-Filion

Boemel

et al. 2006

Eye

View full text Add to dashboard Cite

show abstract

“…Electrophysiology provides objective evaluation of retinal and intracranial visual pathway function to help localise dysfunction, confirm or exclude diagnoses, and give information on disease progression and prognosis. [8][9][10] The role of EDT is potentially more important than in adults, but reliable results may also be more difficult to obtain.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the electrodiagnostic investigation of children using the Greenwich Grading System

Fraser

Burton

Holder

et al. 2004

Eye

View full text Add to dashboard Cite

Purpose To evaluate the contribution of electrodiagnostic testing (EDT) to the management of children in a paediatric ophthalmology service using the Greenwich Grading System (GGS). Methods A retrospective analysis was performed of the case notes of 105 of the 113 paediatric patients referred from the Strabismus and Paediatric Service at Moorfields Eye Hospital for electrophysiological testing over a 1-year period. The GGS was used to quantify the contribution of EDT to the diagnosis, overall investigation, and treatment of each patient. Patients were further subdivided into different diagnostic groups to allow comparison of the value of EDT in different conditions. Results EDT was found to be of value in 91% of the children tested and was considered an essential investigation in 71%. EDT made a new diagnosis in 7% of patients, changed it in 5%, and confirmed or excluded a diagnosis in 79%. EDT made a useful contribution to the overall investigation of 89% of the patients and was considered the only test that could provide the required information in 71%. The results of EDT allowed reassurance and/or explanation with regard to the diagnosis, prognosis, and treatment in 91% of children. In one patient, treatment was changed as a result of EDT. The clinical outcome was not adversely affected in any patient. Conclusions EDT was of value to the clinical management of most of the children reviewed, mainly by confirming or excluding a clinical diagnosis and allowing explanation and reassurance to children and parents. Electrodiagnostic information gave a new or changed diagnosis in 12% of the children.

show abstract

Monitoring Visual Function in Children With Syndromic Craniosynostosis

Liasis¹

2006

Arch Ophthalmol

View full text Add to dashboard Cite

Objective: To compare visual acuity, optic disc appearance, and transient pattern reversal visual evoked potentials as markers of possible visual dysfunction in children with syndromic craniosynostosis. Methods: Serial visual acuity, optic disc appearance, and pattern reversal visual evoked potential data were recorded in 8 patients with syndromic craniosynostosis before and after cranial vault expansion. The pattern reversal visual evoked potentials were analyzed using linear regression modeling, applied to the N80 to P100 amplitude. Results: Serial optic disc appearances were available for all 8 patients and visual acuities for 7 patients. The visual acuity deteriorated in only 1 patient, improved in 4, and fluctuated in 2, before surgery. Of the 8 patients,

show abstract

Electrophysiological assessment of visual pathway function in infants

Cited by 60 publications

References 31 publications

Retinal function in infants with optic nerve hypoplasia: electroretinograms to large patterns and photopic flash

Retinal function in infants with optic nerve hypoplasia: electroretinograms to large patterns and photopic flash

Evaluation of the electrodiagnostic investigation of children using the Greenwich Grading System

Monitoring Visual Function in Children With Syndromic Craniosynostosis

Contact Info

Product

Resources

About