Electrophysiological assessment of language function following stroke

D’Arcy, Ryan C.N.; Marchand, Yannick; Eskes, Gail A.; Harrison, Edmund R.; Phillips, Stephen J.; Major, Alma; Connolly, John F.

doi:10.1016/s1388-2457(03)00007-5

Cited by 60 publications

(49 citation statements)

References 31 publications

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“…Our results with ERPs replicated those of several other research groups using a similar congruency paradigm (Byrne et al, 1999;D'Arcy et al, 2003;Friedrich & Friederici, 2004, 2005a, b, 2010Henderson et al, 2011;Marchand et al, 2002;Torkildsen et al, 2008). A reliable reduction in the amplitude of the N400 was observed in congruent versus incongruent word/picture pairings, but only for the items that were expected to be known to the participants.…”

Section: Discussionsupporting

confidence: 89%

“…For example, Connolly and colleagues (Byrne et al, 1999;Connolly, D'Arcy, Newman, & Kemps, 2000;D'Arcy et al, 2003;Marchand, D'Arcy, & Connolly, 2002) used this type of N400 congruity paradigm to assess receptive vocabulary in a series of studies with various participant groups, including healthy adults, typically developing children, adults with aphasia, and a child with cerebral palsy (for whom motor activity, and thus behavioral response, was limited). They used a variety of behavioral measures to estimate each participant's receptive vocabulary level, then presented congruent and incongruent pictures with words that were within or beyond that participant's vocabulary level.…”

Section: Event-related Potentials In the Study Of Receptive Vocabularmentioning

confidence: 99%

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The concurrent use of three implicit measures (eye movements, pupillometry, and event-related potentials) to assess receptive vocabulary knowledge in normal adults

et al. 2015

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Recent years have seen the advent and proliferation of the use of implicit techniques to study learning and cognition. One such application is the use of event-related potentials (ERPs) to assess receptive vocabulary knowledge. Other implicit assessment techniques that may be well-suited to other testing situations or to use with varied participant groups have not been used as widely to study receptive vocabulary knowledge. We sought to develop additional implicit techniques to study receptive vocabulary knowledge that could augment the knowledge gained from the use of the ERP technique. Specifically, we used a simple forced-choice paradigm to assess receptive vocabulary knowledge in normal adult participants using eye movement monitoring (EM) and pupillometry. In the same group of participants, we also used an N400 semantic incongruity ERP paradigm to assess their knowledge of two groups of words: those expected to be known to the participants (high-frequency, familiar words) and those expected to be unknown (low-frequency, unfamiliar words). All three measures showed reliable differences between the known and unknown words. EM and pupillometry thus may provide insight into receptive vocabulary knowledge similar to that from ERPs. The development of additional implicit assessment techniques may increase the feasibility of receptive vocabulary testing across a wider range of participant groups and testing situations, and may make the conduct of such testing more accessible to a wider range of researchers, clinicians, and educators.

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Section: Discussionsupporting

confidence: 89%

Section: Event-related Potentials In the Study Of Receptive Vocabularmentioning

confidence: 99%

The concurrent use of three implicit measures (eye movements, pupillometry, and event-related potentials) to assess receptive vocabulary knowledge in normal adults

et al. 2015

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“…Historically, ERPs have been limited in terms of their use in clinical realms (e.g., and [D'Arcy et al, 2003]). This has, in part, been due to the need to identify appropriate applications for ERP components.…”

Section: The Profiling Algorithm and Potential Clinical Applicationsmentioning

confidence: 99%

Profiling brain function: Spatiotemporal characterization of normal and abnormal visual activation

Versteeg

Marchand

Mazerolle

et al. 2010

Journal of Neuroscience Methods

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Profiling brain function : Spatiotemporal characterization of normal and abnormal visual activation Abstract ObjectiveIn clinical neuroscience, the utility of evoked and event-related potentials (EPs and ERPs) resides in the temporal information they provide. However, it is largely unknown whether valuable diagnostic information resides within the corresponding spatial patterns. To determine this, the first step involves testing whether -normal‖ versus -abnormal‖ EPs/ERPs can be differentiated based on spatial patterns. In the current study, we present a method that characterizes similarities across individual source maps, called the profile algorithm. The profile algorithm was evaluated in terms of its ability to detect spatial activation differences in myopic individuals with corrected and uncorrected vision. This experiment represents a critical test of the method before applying it to the assessment of perceptual/cognitive functions. MethodsVisual-evoked potentials (VEPs) were recorded from healthy subjects using checkerboard stimulation. The N75 and P100 were examined in individuals with corrected (20/20) and uncorrected vision (20/40 or worse). Results and conclusionN75 and P100 amplitudes and latencies were modulated by vision condition. The profile algorithm differentiated successfully between corrected and uncorrected vision. Its discriminatory power outperformed a more traditional method based on ERP peak amplitude. Subsequent correlations revealed significant relationships between visual impairment and both the components and the spatial activation. Overall, the findings suggested that VEP spatial patterns were sensitive to manipulations of visual acuity. SignificanceThe findings demonstrate that EP/ERP spatial activation can be evaluated at the individual level and compared against normative data. Ultimately, the method may provide a valuable tool for assessing individual spatial activation changes in perceptual/cognitive functions.

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“…Event-related potentials (ERPs), derivatives of the EEG obtained by signal averaging, can even be used to obtain indices of specific stages of sensory and cognitive information processing. Indeed, more than a decade of comprehensive research in this [8]- [11] and other labs [12]- [16] has demonstrated the diagnostic power of several ERPs in assessing cognitive function in behaviorally unresponsive patients. The current letter presents a novel brain wave technology that executes this kind of ERP-based test rapidly and provides a diagnostic measure that blends the clinical features of the GCS with the physiological measurement of conscious awareness.…”

Section: Introductionmentioning

confidence: 99%

Towards Brain First-Aid: A Diagnostic Device for Conscious Awareness

D’Arcy

Hajra

Liu

et al. 2011

IEEE Trans. Biomed. Eng.

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Abstract-When the brain is damaged, evaluating an individual's level of awareness can be a major diagnostic challenge (Is he or she in there?). Existing tests typically rely on behavioral indicators, which are incorrect in as many as one out of every two cases. The current paper presents a diagnostic device that addresses this problem. The technology circumvents behavioral limitations through noninvasive brain wave measurements (electroencephalography, or EEG). Unlike traditional EEG, the device is designed for point-of-care use by incorporating a portable, userfriendly, and stable design. It uses a novel software algorithm that automates subject stimulation, data acquisition/analysis, and the reporting of results. The test provides indicators for five identifiable levels of neural processing: sensation, perception, attention, memory, and language. The results are provided as rapidly obtained diagnostic, reliability, validity, and prognostic scores. The device can be applied to a wide variety of patients across a host of different environments. The technology is designed to be wireless-enabled for remote monitoring and assessment capabilities. In essence, the device is developed to scan for conscious awareness in order to optimize subsequent patient care.

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Electrophysiological assessment of language function following stroke

Cited by 60 publications

References 31 publications

The concurrent use of three implicit measures (eye movements, pupillometry, and event-related potentials) to assess receptive vocabulary knowledge in normal adults

The concurrent use of three implicit measures (eye movements, pupillometry, and event-related potentials) to assess receptive vocabulary knowledge in normal adults

Profiling brain function: Spatiotemporal characterization of normal and abnormal visual activation

Towards Brain First-Aid: A Diagnostic Device for Conscious Awareness

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