Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device

Waldie, Anna M; Hobby, Angharad; Chow, Isabelle; Cornish, Elisa E; Indusegaran, Mathura; Pekacka, Aleksandra; Nguyen, Phuc Vuong; Fraser, Clare L.; Binns, Alison; Stanford, Miles; Hammond, Christopher J; McCluskey, Peter; Grigg, John; Mahroo, Omar A.

doi:10.1167/tvst.11.5.23

Cited by 1 publication

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References 22 publications

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“…These are summarised in Table 3 . Some have been incorporated in portable devices, with findings reported in several studies [ 3 , 31 , 33 , 35 , 36 , 39 ]. An ISCEV guide has been published reviewing the range of standard and extended protocols [ 53 ].…”

Section: Some Current and Future Developmentsmentioning

confidence: 99%

Visual electrophysiology and “the potential of the potentials”

Mahroo

2023

Eye

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Visual electrophysiology affords direct, quantitative, objective assessment of visual pathway function at different levels, and thus yields information complementary to, and not necessarily obtainable from, imaging or psychophysical testing. The tests available, and their indications, have evolved, with many advances, both in technology and in our understanding of the neural basis of the waveforms, now facilitating more precise evaluation of physiology and pathophysiology. After summarising the visual pathway and current standard clinical testing methods, this review discusses, non-exhaustively, several developments, focusing particularly on human electroretinogram recordings. These include new devices (portable, non-mydiatric, multimodal), novel testing protocols (including those aiming to separate rod-driven and cone-driven responses, and to monitor retinal adaptation), and developments in methods of analysis, including use of modelling and machine learning. It is likely that several tests will become more accessible and useful in both clinical and research settings. In future, these methods will further aid our understanding of common and rare eye disease, will help in assessing novel therapies, and will potentially yield information relevant to neurological and neuro-psychiatric conditions.

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